_{Publikationen:
Abteilung für Hochfeld-Magnetresonanz}

Zeitschriftenartikel (456)

1. 1.
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   Avdievich, N.; Solomakha, G.; Ruhm, L.; Scheffler, K.; Henning, A.: Evaluation of short folded dipole antennas as receive elements of ultra‐high‐field human head array. Magnetic Resonance in Medicine 82 (2), S. 811 - 824 (2019)
2. 2.
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   Goerke, S.; Soehngen, Y.; Deshmane, A.; Zaiss, M.; Breitling, A.; Boyd, P.; Herz, K.; Zimmermann, F.; Klika, K.; Schlemmer, H.-P. et al.; Paech, D.; Ladd, M.; Bachert, P.: Relaxation‐compensated APT and rNOE CEST‐MRI of human brain tumors at 3 T. Magnetic Resonance in Medicine 82 (2), S. 622 - 632 (2019)
3. 3.
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   Liebert, A.; Zaiss, M.; Gumbrecht, R.; Tkotz, K.; Linz, P.; Schmitt, B.; Laun, F.; Doerfler, A.; Uder, M.; Nagel, A.: Multiple interleaved mode saturation (MIMOSA) for B1 + inhomogeneity mitigation in chemical exchange saturation transfer. Magnetic Resonance in Medicine 82 (2), S. 693 - 705 (2019)
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   Viessmann, O.; Scheffler, K.; Bianciardi, M.; Wald, L.; Polimeni, J.: Dependence of resting-state fMRI fluctuation amplitudes on cerebral cortical orientation relative to the direction of B0 and anatomical axes. NeuroImage 196, S. 337 - 350 (2019)
5. 5.
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   Lindig, T.; Bender, B.; Kumar, V.; Hauser, T.-K.; Grodd, W.; Brendel, B.; Just, J.; Synofzik, M.; Klose, U.; Scheffler, K. et al.; Ernemann, U.; Schöls, L.: Pattern of Cerebellar Atrophy in Friedreich’s Ataxia: Using the SUIT Template. The Cerebellum 18 (3), S. 435 - 447 (2019)
6. 6.
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   Zaiss, M.; Deshmane, A.; Schuppert, M.; Herz, K.; Glang, F.; Ehses, P.; Lindig, T.; Bender, B.; Ernemann, U.; Scheffler, K.: DeepCEST: 9.4 T Chemical exchange saturation transfer MRI contrast predicted from 3 T data – a proof of concept study. Magnetic Resonance in Medicine 81 (6), S. 3901 - 3914 (2019)
7. 7.
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   Avdievich, N.; Giapitzakis, I.-A.; Bause, J.; Shajan, G.; Scheffler, K.; Henning, A.: Double‐row 18‐loop transceive–32‐loop receive tight‐fit array provides for whole‐brain coverage, high transmit performance, and SNR improvement near the brain center at 9.4T. Magnetic Resonance in Medicine 81 (5), S. 3392 - 3405 (2019)
8. 8.
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   Buckenmaier, K.; Scheffler, K.; Plaumann, M.; Fehling, P.; Bernarding, J.; Rudolph, M.; Back, C.; Koelle, D.; Kleiner, R.; Hövener, J.-B. et al.; Pravdivtsev, A.: Simultaneous observation of high order multiple quantum coherences at ultralow magnetic fields. (eingereicht)
9. 9.
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   Deshmane, A.; McGivney, D.; Ma, D.; Jiang, Y.; Badve, C.; Gulani, V.; Seiberlich, N.; Griswold, M.: Partial volume mapping using magnetic resonance fingerprinting. NMR in Biomedicine 32 (5), S. 1 - 17 (2019)
10. 10.
    MPG.PuRe

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    Kohl, S.; Veit, R.; Spetter, M.; Günther, A.; Rina, A.; Lührs, M.; Birbaumer, N.; Preissl, H.; Hallschmid, M.: Real-time fMRI neurofeedback training to improve eating behavior by self-regulation of the dorsolateral prefrontal cortex: A randomized controlled trial in overweight and obese subjects. NeuroImage 191, S. 596 - 609 (2019)
11. 11.
    MPG.PuRe

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    Ma, D.; Jones, S.; Deshmane, A.; Sakaie, K.; Pierre, E.; Larvie, M.; McGivney, D.; Blümcke, I.; Krishnan, B.; Lowe, M. et al.; Gulani, V.; Najm, I.; Griswold, M.; Wang, Z.: Development of high‐resolution 3D MR fingerprinting for detection and characterization of epileptic lesions. Journal of Magnetic Resonance Imaging 49 (5), S. 1333 - 1346 (2019)
12. 12.
    MPG.PuRe

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    Martirosian, P.; Pohmann, R.; Schraml, C.; Schwartz, M.; Kuestner, T.; Schwenzer, N.; Scheffler, K.; Nikolaou, K.; Schick, F.: Spatial-temporal perfusion patterns of the human liver assessed by pseudo-continuous arterial spin labeling MRI. Zeitschrift für Medizinische Physik 29 (2), S. 173 - 183 (2019)
13. 13.
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    Pilotto, A.; Blau, N.; Leks, E.; Schulte, C.; Deuschl, C.; Zipser, C.; Piel, D.; Freisinger, P.; Gramer, G.; Kölker, S. et al.; Haas, D.; Burgard, P.; Nawroth, P.; Georg, H.; Scheffler, K.; Berg, D.; Trefz, F.: Cerebrospinal fluid biogenic amines depletion and brain atrophy in adult patients with phenylketonuria. Journal of Inherited Metabolic Disease 42 (3), S. 398 - 406 (2019)
14. 14.
    MPG.PuRe

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    Zhan, Y.; Zhang, B.; Zheng, W.; Liu, W.; Wang, C.; Li, H.; Chen, L.; Yu, L.; Walter, M.; Li, M. et al.; Li, M.; Ying, Y.: A preliminary study of anti-suicidal efficacy of repeated ketamine infusions in depression with suicidal ideation. Journal of Affective Disorders 251, S. 205 - 212 (2019)
15. 15.
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    Deshmane, A.; Zaiss, M.; Lindig, T.; Herz, K.; Schuppert, M.; Gandhi, C.; Bender, B.; Ernemann, U.; Scheffler, K.: 3D gradient echo snapshot CEST MRI with low power saturation for human studies at 3T. Magnetic Resonance in Medicine 81 (4), S. 2412 - 2423 (2019)
16. 16.
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    Neugebauer, K.; Hammans, C.; Wensing, T.; Kumar, V.; Grodd, W.; Mevissen, L.; Sternkopf, M.; Novakovic, A.; Abel, T.; Habel, U. et al.; Nickl-Jockschat, T.: NGF serum levels are associated with regional gray matter volume differences in schizophrenia patients. Frontiers in Psychiatry 10, 275, S. 1 - 14 (2019)
17. 17.
    MPG.PuRe

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    Pais-Roldán, P.; Edlow, B.; Jiang, Y.; Stelzer, J.; Zou, M.; Yu, X.: Multimodal assessment of recovery from coma in a rat model of diffuse brainstem tegmentum injury. NeuroImage 189, S. 615 - 630 (2019)
18. 18.
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    Perlman, O.; Herz, K.; Zaiss, M.; Cohen, O.; Rosen, M.; Farrar, C.: CEST MR-Fingerprinting: practical considerations and insights for acquisition schedule design and improved reconstruction. (eingereicht)
19. 19.
    MPG.PuRe

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    Scheffler, K.; Heule, R.; Baez-Yanez, M.; Kardatzki, B.; Lohmann, G.: The BOLD sensitivity of rapid steady-state sequences. Magnetic Resonance in Medicine 81 (4), S. 2526 - 2535 (2019)
20. 20.
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    Scheffler, K.; Loktyushin, A.; Bause, J.; Aghaeifar, A.; Steffen, T.; Schölkopf, B.: Spread‐spectrum magnetic resonance imaging. Magnetic Resonance in Medicine Epub ahead (2019)
21. 21.
    MPG.PuRe

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    Schwarz, L.; Kreifelts, B.; Wildgruber, D.; Erb, M.; Scheffler, K.; Ethofer, T.: Properties of face localizer activations and their application in functional magnetic resonance imaging (fMRI) fingerprinting. PLoS One 14 (4), S. 1 - 21 (2019)
22. 22.
    MPG.PuRe

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    Dreher, C.; Oberhollenzer, J.; Meissner, J.; Windschuh, J.; Scheunke, P.; Regnery, S.; Sahm, F.; Bickelhaupt , S.; Bendszus , M.; Wick, W. et al.; Unterberg, A.; Zaiss, M.; Bachert, P.; Ladd, M.; Schlemmer, H.; Radbruch, A.; Paech, D.: Chemical exchange saturation transfer (CEST) signal intensity at 7T MRI of WHO IV° gliomas is dependent on the anatomic location. Journal of Magnetic Resonance Imaging 49 (3), S. 777 - 785 (2019)
23. 23.
    MPG.PuRe

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    Göksu, C.; Scheffler, K.; Siebner, H.; Thielscher, A.; Hanson, L.: The stray magnetic fields in Magnetic Resonance Current Density Imaging (MRCDI). Physica Medica 59, S. 142 - 150 (2019)
24. 24.
    MPG.PuRe

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    Heule, R.; Pfeuffer, J.; Meyer, C.; Bieri, O.: Simultaneous B1 and T1 mapping using spiral multislice variable flip angle acquisitions for whole‐brain coverage in less than one minute. Magnetic Resonance in Medicine 81 (3), S. 1876 - 1889 (2019)
25. 25.
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    Koch, K.; Stegmaier, S.; Schwarz, A.; Erb, M.; Thomas, M.; Scheffler, K.; Wildgruber, D.; Nieratschker, V.; Ethofer, T.: CACNA1C risk variant affects microstructural connectivity of the amygdala. NeuroImage: Clinical 22, 101774, S. 1 - 8 (2019)
26. 26.
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    Kujawa, A.; Kim, M.; Demetriou, E.; Anemone, A.; Livio Longo, D.; Zaiss, M.; Golay, X.: Assessment of a clinically feasible Bayesian fitting algorithm using a simplified description of Chemical Exchange Saturation Transfer (CEST) imaging. Journal of Magnetic Resonance 300, S. 120 - 134 (2019)
27. 27.
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    Avram, L.; Havel, V.; Shusterman-Krush, R.; Iron, M.; Zaiss, M.; Sindelar, V.; Bar-Shir, A.: Dynamic Interactions in Synthetic Receptors: A Guest Exchange Saturation Transfer Study. Chemistry – A European Journal 25 (7), S. 1687 - 1690 (2019)
28. 28.
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    Buckenmaier, K.; Pedersen, A.; SanGiorgio, P.; Scheffler, K.; Clarke, J.; Inglis, B.: Feasibility of Functional MRI at Ultralow Magnetic Field via Changes in Cerebral Blood Volume. NeuroImage 186, S. 185 - 191 (2019)
29. 29.
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    Colic, L.; McDonnell, C.; Li, M.; Woelfer, M.; Liebe, T.; Kretzschmar, M.; Speck, O.; Schott, B.; Bianchi, M.; Walter, M.: Neuronal glutamatergic changes and peripheral markers of cytoskeleton dynamics change synchronically 24 h after sub-anaesthetic dose of ketamine in healthy subjects. Behavioural Brain Research 359, S. 312 - 319 (2019)
30. 30.
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    Ho, T.; Gutman, B.; Pozzi, E.; Grabe, H.; Hosten, N.; Wittfeld, K.; Völzke, H.; Baune, B.; Dannlowski, U.; Förster, K. et al.; Grotegerd, D.; Redlich, R.; Jansen, A.; Kircher, T.; Krug, A.; Meinert, S.; Nenadic, I.; Opel, N.; Dinga, R.; Veltman, D.; Schnell, K.; Veer, I.; Walter, H.; Gotlib, I.; Sacchet, M.; Aleman, A.; Groenewold, N.; Stein, D.; Li, M.; Walter, M.; Jahanshad, N.; Thompson, P.; Sämann, P.; Schmaal, L.: Subcortical Shape Alterations in Major Depressive Disorder: Findings from the ENIGMA Major Depressive Disorder Working Group. (eingereicht)
31. 31.
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    Paech, D.; Dreher, C.; Regnery, S.; Meissner, J.; Goerke, S.; Windschuh, J.; Oberhollenzer, J.; Schultheiss, M.; Deike-Hofmann, K.; Bickelhaupt, S. et al.; Radbruch, A.; Zaiss, M.; Unterberg , A.; Wick, W.; Bendszus, M.; Bachert, P.; Ladd, M.; Schlemmer, H.: Relaxation-compensated amide proton transfer (APT) MRI signal intensity is associated with survival and progression in high-grade glioma patients. European Radiology Epub ahead (2019)
32. 32.
    MPG.PuRe

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    Eschelbach, M.; Aghaeifar, A.; Bause, J.; Handwerker, J.; Anders, J.; Engel, E.-M.; Thielscher, A.; Scheffler, K.: Comparison of prospective head motion correction with NMR field probes and an optical tracking system. Magnetic Resonance in Medicine 81 (1), S. 719 - 729 (2019)
33. 33.
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    Herz, K.; Gandhi, C.; Schuppert, M.; Deshmane, A.; Scheffler, K.; Zaiss, M.: CEST imaging at 9.4 T using adjusted adiabatic spin‐lock pulses for on‐ and off‐resonant T1⍴‐dominated Z‐spectrum acquisition. Magnetic Resonance in Medicine 81 (1), S. 275 - 290 (2019)
34. 34.
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    Juras, V.; Schreiner, M.; Laurent, D.; Zbýň, Š.; Mlynarik, V.; Szomolanyi , P.; Hager, B.; Scotti, C.; Goldhahn, J.; Heule, R. et al.; Bieri, O.; Trattnig, S.: The comparison of the performance of 3 T and 7 T T2 mapping for untreated low-grade cartilage lesions. Magnetic Resonance Imaging 55, S. 86 - 92 (2019)
35. 35.
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    Wenger, C.; Miranda, P.; Salvador, R.; Thielscher, A.; Bomzon, Z.: A review on Tumor Treating Fields (TTFields): Clinical implications inferred from computational modeling. IEEE Reviews in Biomedical Engineering 11, S. 195 - 207 (2019)
36. 36.
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    Windschuh, J.; Zaiss, M.; Ehses, P.; Lee, J.; Jerschow, A.; Regatte, R.: Assessment of frequency drift on CEST MRI and dynamic correction: application to gagCEST at 7 T. Magnetic Resonance in Medicine 81 (1), S. 573 - 582 (2019)
37. 37.
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    Zaiss, M.; Herz, K.; Deshmane, A.; Kim, M.; Golay, X.; Lindig, T.; Bender, B.; Ernemann, U.; Scheffler, K.: Possible artifacts in dynamic CEST MRI due to motion and field alterations. Journal of Magnetic Resonance 298, S. 16 - 22 (2019)
38. 38.
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    Buckenmaier, K.; Rudolph, M.; Fehling, P.; Steffen, T.; Back, C.; Bernard, R.; Pohmann, R.; Bernarding, J.; Kleiner, R.; Koelle, D. et al.; Plaumann, M.; Scheffler, K.: Mutual benefit achieved by combining ultralow-field magnetic resonance and hyperpolarizing techniques. Review of Scientific Instruments 89 (12), 125103, S. 1 - 12 (2018)
39. 39.
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    Ladd, M.; Bachert, P.; Meyerspeer , M.; Moser, E.; Nagel, A.; Norris, D.; Schmitter, S.; Speck, O.; Straub, S.; Zaiss, M.: Pros and cons of ultra-high-field MRI/MRS for human application. Progress in Nuclear Magnetic Resonance Spectroscopy 109, S. 1 - 50 (2018)
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    Lohmann, G.; Loktyushin, A.; Stelzer, J.; Scheffler, K.: Eigenvector centrality mapping for ultrahigh resolution fMRI data of the human brain. (eingereicht)
41. 41.
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    Nassirpour, S.; Chang, P.; Avdievitch, N.; Henning, A.: Compressed sensing for high‐resolution nonlipid suppressed 1H FID MRSI of the human brain at 9.4T. Magnetic Resonance in Medicine 80 (6), S. 2311 - 2325 (2018)
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    Brodt, S.; Gais, S.; Beck, J.; Erb, M.; Scheffler, K.; Schönauer, M.: Fast track to the neocortex: A memory engram in the posterior parietal cortex. Science 362 (4618), S. 1045 - 1048 (2018)
43. 43.
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    Paech, D.; Windschuh, J.; Oberhollenzer, J.; Dreher, C.; Sahm, F.; Meissner, J.; Goerke, S.; Schuenke, P.; Zaiss, M.; Regnery, S. et al.; Bickelhaupt, S.; Bäumer, P.; Bendszus, M.; Wick, W.; Unterberg, A.; Bachert, P.; Ladd, M.; Schlemmer, H.; Radbruch, A.: Assessing the predictability of IDH mutation and MGMT methylation status in glioma patients using relaxation-compensated multi-pool CEST MRI at 7.0 Tesla. Neuro-Oncology 20 (12), S. 1661 - 1671 (2018)
44. 44.
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    Pais Roldán, P.; Biswal, B.; Scheffler, K.; Yu, X.: Identifying Respiration-Related Aliasing Artifacts in the Rodent Resting-State fMRI. Frontiers in Neuroscience 12, 788, S. 1 - 14 (2018)
45. 45.
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    Pfrommer, A.; Henning, A.: The ultimate intrinsic signal-to-noise ratio of loop- and dipole-like current patterns in a realistic human head model. Magnetic Resonance in Medicine 80 (5), S. 2122 - 2138 (2018)
46. 46.
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    Aghaeifar, A.; Mirkes, C.; Bause, J.; Steffen, T.; Avdievitch, N.; Henning, A.; Scheffler, K.: Dynamic B0 shimming of the human brain at 9.4 T with a 16-channel multi-coil shim setup. Magnetic Resonance in Medicine 80 (4), S. 1714 - 1725 (2018)
47. 47.
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    Demetriou, E.; Tachrount, M.; Zaiss, M.; Shmueli, K.; Golay, X.: PRO-QUEST: a rapid assessment method based on progressive saturation for quantifying exchange rates using saturation times in CEST. Magnetic Resonance in Medicine 80 (4), S. 1638 - 1654 (2018)
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    Lohmann, G.; Stelzer, J.; Lacosse, E.; Kumar, V.; Mueller, K.; Kuehn, E.; Grodd, W.; Scheffler, K.: LISA improves statistical analysis for fMRI. Nature Communications 9, 4014, S. 1 - 9 (2018)
49. 49.
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    Müller-Lutz, A.; Lijmani, A.; Stabinska, J.; Zaiss, M.; Boos, J.; Wittsack, H.-J.: Comparison of B0 versus B0 and B1 field inhomogeneity correction for glycosaminoglycan chemical exchange saturation transfer imaging. Magnetic Resonance Materials in Physics, Biology and Medicine 31 (5), S. 645 - 651 (2018)
50. 50.
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    Zaiss, M.; Schuppert, M.; Deshmane, A.; Herz, K.; Ehses, P.; Füllbier, L.; Lindig, T.; Bender, B.; Ernemann, U.; Scheffler, K.: Chemical exchange saturation transfer MRI contrast in the human brain at 9.4 T. NeuroImage 179, S. 144 - 155 (2018)
51. 51.
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    Avdievich, N.; Giapitzakis, I.; Pfrommer, A.; Shajan, G.; Scheffler, K.; Henning, A.: Decoupling of a double‐row 16‐element tight‐fit transceiver phased array for human whole‐brain imaging at 9.4 T. NMR in Biomedicine 31 (9), S. 1 - 13 (2018)
52. 52.
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    Liebe, T.; Li, M.; Colic, L.; Munk, M.; Sweeney-Reed , C.; Woelfer, M.; Kretzschmar, M.; Steiner, J.; von Düring, F.; Behnisch, G. et al.; Schott, B.; Walter, M.: Ketamine influences the locus coeruleus norepinephrine network, with a dependency on norepinephrine transporter genotype: a placebo controlled fMRI study. NeuroImage: Clinical 20, S. 715 - 723 (2018)
53. 53.
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    Loktyushin, A.; Ehses, P.; Schölkopf, B.; Scheffler, K.: Autofocusing-based phase correction. Magnetic Resonance in Medicine 80 (3), S. 958 - 968 (2018)
54. 54.
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    Spanò, B.; Giuletti, G.; Pisani, V.; Morreale, M.; Tuzzi, E.; Nocentini, U.; Francia, A.; Caltagirone, C.; Bozzali, M.; Cercignani, M.: Disruption of neurite morphology parallels MS progression. Neurology: Neuroimmunology & Neuroinflammation 5 (6), S. 1 - 11 (2018)
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    Giapitzakis, I.; Avdievich, N.; Henning, A.: Characterization of macromolecular baseline of human brain using metabolite cycled semi-LASER at 9.4T. Magnetic Resonance in Medicine 80 (2), S. 462 - 473 (2018)
56. 56.
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    Hovener, J.; Pravdivtsev, A.; Kidd, B.; Bowers, C.; Glöggler, S.; Kovtunov, K.; Plaumann, M.; Katz-Brull, R.; Buckenmaier, K.; Jerschow, A. et al.; Reineri, F.; Theis, T.; Shchepin, R.; Wagner, S.; Zacharias, N.; Bhattacharya, P.; Chekmenev, E.: Parahydrogen-based Hyperpolarization for Biomedicine. Angewandte Chemie: International edition 57 (35), S. 11140 - 11162 (2018)
57. 57.
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    Koch, K.; Stegmaier, S.; Schwarz, L.; Erb, M.; Reinl, M.; Scheffler, K.; Wildgruber, D.; Ethofer, T.: Neural correlates of processing emotional prosody in unipolar depression. Human Brain Mapping 39 (8), S. 3419 - 3427 (2018)
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    Koten, J.; Schueppen, A.; Kumar, V.; Wood, G.: Occurrence of non-western magic in the European brain. (eingereicht)
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    Loureiro, J.; Himmelbach, M.; Ethofer, T.; Pohmann, R.; Martin, P.; Bause, J.; Scheffler, K.; Grodd, W.; Hagberg, G.: In-vivo quantitative structural imaging of the human midbrain and the superior colliculus at 9.4T. NeuroImage 177, S. 117 - 128 (2018)
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    Wyss, P.; Bianchini, C.; Scheidegger, M.; Giapitzakis, I.; Hock, A.; Fuchs, A.; Henning, A.: In vivo estimation of transverse relaxation time constant (T2) of 17 human brain metabolites at 3T. Magnetic Resonance in Medicine 80 (2), S. 452 - 461 (2018)
61. 61.
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    Chang, P.; Nassirpour, S.; Eschelbach, M.; Scheffler, K.; Henning, A.: Constrained optimization for position calibration of an NMR field camera. Magnetic Resonance Imaging 80 (1), S. 380 - 390 (2018)
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    Lee, I.-S.; Kullmann, S.; Scheffler, K.; Preissl, H.; Enck, P.: Fat label compared with fat content: gastrointestinal symptoms and brain activity in functional dyspepsia patients and healthy controls. The American Journal of Clinical Nutrition 108 (1), S. 127 - 135 (2018)
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    Colic, M.; Woelfer, L.; Colic, M.; Leutritz, A.; Liebe, T.; Fensky, L.; Sen, Z.; Li, M.; Hoffmann, J.; Kretzschmar, M. et al.; Isermann, B.; Walter, M.: Delayed increase of thrombocyte levels after a single sub-anesthetic dose of ketamine: A randomized trial. European Neuropsychopharmacology 28 (6), S. 701 - 709 (2018)
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    Fichtner, N.; Giapitzakis, I.-A.; Avdievich, N.; Mekle, R.; Zaldivar, D.; Henning, A.; Kreis, R.: In vivo characterization of the downfield part of 1H MR spectra of human brain at 9.4T: Magnetization exchange with water and relation to conventionally determined metabolite content. Magnetic Resonance in Medicine 79 (6), S. 2863 - 2873 (2018)
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    Goerke, C.; Breitling, J.; Zaiss, M.; Windschuh, J.; Kunz, P.; Schuenke, P.; Paech, D.; Longo, D.; Klika, K.; Ladd, M. et al.; Bachert, P.: Dual-frequency irradiation CEST-MRI of endogenous bulk mobile proteins. NMR in Biomedicine 31 (6), S. 1 - 14 (2018)
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    Jusyte, A.; Zaretskaya, N.; Höhnle, N.; Bartels, A.; Schönenberg, M.: Binocular rivalry transitions predict inattention symptom severity in adult ADHD. European Archives of Psychiatry and Clinical Neuroscience 268 (4), S. 373 - 382 (2018)
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    Krikken, E.; Khlebnikov, V.; Zaiss, M.; Jibodh, R.; van Diest, P.; Luijten, P.; Klomp, D.; van Laarhoven, H.; Wijnen, J.: Amide chemical exchange saturation transfer at 7 T: a possible biomarker for detecting early response to neoadjuvant chemotherapy in breast cancer patients. Breast Cancer Research 20 (51), S. 1 - 9 (2018)
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