Molecular MRI using chemical exchange saturation transfer at 9.4T and 3T
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Find resources for CEST-MRI on the project page
Fast magentization-prepared imaging readouts
For all CEST experiments the magnetization must be prepared by saturation which takes several seconds to build up. Subsequently this magentization state must be read out as quickly as possible before it is lost again. Thus, one major project that forms the basis of all subprojects is the development of fast imaging readouts.
Hand in hand with sequence development , evaluation must be refined; evaluation software is shared on our project webiste www.cest-sources.org.
We are part of the EU Project GLINT
The promise of the technique is to give a subject a drink of soda with high sugar and see if tumors light up due to their enhanced metabolism. First applications in vivo showed glucoCEST signal enhancmenet in tumor areas, see our .
CEST allows MRI imaging of protein content, conformation and denaturation. All of these might be interesting markers in brain tumors as well as other pathologies, especially in tumors it might overcome the need for contrast agents (see Figure 1). In addition, protein signals have a correlation with pH that is investitgated for use of a pH-weighted imaging.
Figure 1: Comparison of Gadolinium enhanced (left column) and 'Downfield NOE-suppressd amide-CEST effect' in human glioblastoma patients revealed that amide-CEST contrast forms a unique contrast that delineates tumor regions and show remarkable overlap with the gadolinium contrast enhancement.
Post-Doc and leader of the project 'Molecular MRI using chemical exchange saturation transfer at 9.4T and 3T' at MPI, Tübingen
Degrees: Ph.D. in Physics
2004 2009: Physics, Ruprecht-Karls University, Heidelberg, Germany
2009-2010: graduate student at Ruprecht-Karls Universität in the
Dep. Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg
June 2010 Graduation: Master of Physics
February 2011-February 2014 Ph.D. student, stipendiary of Helmholtz-Community at DKFZ
January-May 2013: Research Stay at Vanderbilt University, Nashville, TN in Gochberg lab
supported by a stipend of DAAD
February 2014: Promotion in physics: Dr. rer. nat
2014-2016: Post-Doc and leader of the project group CEST imaging at DKFZ, Heidelberg
June 2015: Research Stay at Molecular Biology Center Torino, Silvio Aimes Lab
October-November 2015: Research Stay Utrecht Medical Center, Dennis Klomps Lab
since 2016: Post-Doc and leader of the project CEST imaging at MPI, Tübingen
Young Investigator Award of the Journal of Magnetic Resonance (JMR) at ENC 2014, Boston
Gorter award 2013 (first prize) of the German chapter of the International Society for Magnetic Resonance in Medicine (ISMRM), Freiburg
Competitive Grants: DFG grant : qCEST- Quantitative Chemical Exchange saturation transfer MR imaging of brain tumors at ultra high fields