Computational Neuroscience

Computational Neuroscience

Decision-making in the brain

The main focus of the department is building and testing theories and computational models of neural processing, with a particular emphasis on decision-making, learning and representation. This covers the ways that humans and other animals come to choose appropriate actions in the face of rewards and punishments, and the ways and goals of the process by which they come to form neural representations of the world. The models are informed and constrained by neurobiological, psychological and ethological data.

We also study the consequences for neurological and psychiatric disease when these mechanisms, or their embedding in their environment, break down. These areas are developing and expanding very quickly because of technical innovations in cognitive science, artificial intelligence, neuroscience, psychiatry and in large-scale natural experiments.

We perform behavioural and neuroimaging experiments of our own, and work in close collaborations with a panoply of other experimental and theoretical groups.

There are three main current directions: neuromodulation, meta-control and computational psychiatry.

Neuromodulation

The neuromodulators dopamine, serotonin, acetylcholine and norepinephrine powerfully regulate a host of critical functions in the brain, and are involved or therapeutically manipulated in many diseases. Ideas abound about the functional associates of these substances - their representation of computationally meaningful quantities such as predictions of, and prediction errors for, affectively important outcomes, and different sorts of uncertainty. New technologies for recording and manipulating these neuromodulators are being developed; we exploit these to address critical questions about their function.

Kevin Lloyd
Ariane Wiegand
Sahiti Chebolu
Pawel Pierzchlewicz

Neural Reinforcement Learning

Neural reinforcement learning covers the core theory, algorithms and implementations of adaptive decision-making. These include meta-control, which is the control of control - the way that decision-making systems in the brain are themselves regulated online and offline in order to generate adaptive behaviour in the face of substantial real and opportunity costs for the engagement of the neural machinery involved. We also study ways of creating and adapting representations, aspects of the utility afforded to states and the associated risk-sensitivity; the nature and effect of the social environments of decision-makers. We develop new, computationally-informed, behavioural tasks, and adopt new imaging analysis methods to examine these processes in functional and temporal detail.

Aenne Brielmann
Sebastian Bruijns
Chris Gagne
Corinna Schulz
Franziska Bröker
Gabriele Bellucci
Sarah Master
Lion Schulz
Noemi Elteto
Mihaly Banyai
Nitay Alon
Sara Ershadmanesh
Oleg Solopchuk
Andrej Ilić
Georgy Antonov
Rachit Dubey 
Tamer Ajaj
Philipp Schwartenbeck

Computational Psychiatry

Our understanding of decision-making in the healthy population has now advanced to the point that we can use it to investigate characteristic modes of failure. This provides precise, process- and circuit-oriented hypotheses for understanding symptoms and causes of mental dysfunction. In turn, this richly couples notionally organic and psychological concerns, and provides new methods for classification and prediction. In turn, as we deepen our understanding of failure modes, an important window is opened onto normal cognition.

Chris Gagne
Shervin Safavi
Terezie Sedlinska

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