News 2016
New PhD student in the group MR Neuroimaging Agents
Saturday, 01.10.2016 10:00
Gaoji Wang has joined the group as the fellow of China Scholarship Council (CSC). We greatly appreciate the CSC support and wish luck to Gaoji in his PhD project !
New publication in Chemical Communications
Thursday, 14.07.2016 10:00
We report the preparation of a chelator that serves as platform for multicontrast MRI. Namely, its paramagnetic complexes can be utilized as T1-weighted, paraCEST or 19F MRI contrast agents. They exhibit interesting properties and their potential was demonstrated through a series of MRI studies on tube phantoms and animals.
Link to the article: N. Cakić, T. Savić, J. Stricker-Shaver, V. Truffault, C. Platas-Iglesias, C. Mirkes, R. Pohmann, K. Scheffler, G. Angelovski, “Paramagnetic Lanthanide Chelates for Multicontrast MRI”, Chem. Commun. 2016, 52, 9224-9227.
New publication in Angewandte Chemie
Friday, 10.06.2016 10:00
In this Minireview, Goran briefly summarizes the design principles for preparation of bioresponsive contrast agents for MRI. Their description is followed by the list of practical issues and challenges related to the characterization of these agents in vitro and in vivo. Finally, possible directions for preparation and wider implementation of these probes in functional MRI were suggested, highlighting the critical steps for planning and execution of such multidisciplinary projects. The article is published in English and German languages.
Link to the article: G. Angelovski. “What We Can Really Do with Bioresponsive MRI Contrast Agents”, Angew. Chem. Int. Ed. 2016, 55, 7038-7046. (in English)
Link to the article: G. Angelovski. “Biosensitive Kontrastmittel für die Magnetresonanztomographie – was wir mit ihnen wirklich tun können”, Angew. Chem. 2016, 128, 7152-7161. (in German)
New publication in ACS Sensors
Friday, 27.05.2016 10:00
Here we introduce a new approach which could be used for detection of MR signal changes produced by bioresponsive MRI agents. We developed a nanosized, Ca-sensitive dendrimeric probe that changes T1 and T2 relaxation times with different magnitudes. The change in their ratio is rapidly recorded by means of a balanced steady-state free precession (bSSFP) imaging protocol. The employed methodology results in an almost four times greater signal gain per unit of time as compared to conventional T1-weighted imaging with small sized contrast agents and is well suitable for detection of physiological events with fast kinetics.
Link to the article: S. Gündüz, T. Savić, R. Pohmann, N. K. Logothetis, K. Scheffler, G. Angelovski. “Ratiometric Bioresponsive MRI Contrast Agent for Rapid Monitoring of Biological Processes”, ACS Sens. 2016, 1, 483-487.
For this work, the author portraits of Serhat and Tanja have been introduced to the readers of ACS Sensors.
Link to the author portraits: S. M. Liu. “Introducing Our Authors”, ACS Sens. 2016, 1, 462-463.
New publication in Dalton Transactions
Thursday, 21.04.2016 10:00
We prepared three new bismacrocyclic Ln(III) complexes as potential chemical exchange saturation transfer (CEST) MRI contrast agents. We investigated their CEST effects in presence of Ca(II), and analyzed their properties by means of luminescence steady-state emission and lifetime spectroscopy, NMR spectroscopy and potentiometric titrations. The findings provide an important set of information that will aid better design of future bioresponsive agents for CEST MRI.
Link to the article: N. Cakić, T. Ž. Verbić, R. M. Jelić, C. Platas-Iglesias, G. Angelovski. “Synthesis and characterisation of bismacrocyclic DO3A-amide derivatives – an approach towards metal-responsive PARACEST agents” Dalton Trans. 2016, 45, 6555-6565.
New publication in Biomacromolecules
Montag 11.04.2016 10:00
In this work, we report the preparation of the new class of liposome-based, Ca-sensitive MRI agents. We prepared a novel amphiphilic ligand which was incorporated into the liposome bilayer. A remarkable increase of ~420% in longitudinal relaxivity r1, at 25 °C and 21.5 MHz in the absence and presence of Ca(II), respectively, was achieved by the most active liposomal formulation. To the best of our knowledge, this is the highest change in r1 observed for Ca-sensitive agents at physiological pH at low magnetic fields.
Link to the article: F. Garello, S. Vibhute, S. Gündüz, N. K. Logothetis, E. Terreno, G. Angelovski. “Innovative Design of Ca-Sensitive Paramagnetic Liposomes Results in an Unprecedented Increase in Longitudinal Relaxivity”, Biomacromolecules 2016, 17, 1303-1311.