Goran Angelovski

Alumni Department Physiology of Cognitive Processes
Alumni of the Reasearch Group MR Neuroimaging Agents

Main Focus


The group of Dr. Angelovski has moved to the International Center for Primate Brain Research (ICPBR) of Chinese Academy of Sciences (CAS) in Shanghai. If you want to learn about his research at the ICPBR and vacancies in the new lab, please visit: http://english.cebsit.cas.cn/lab/angelovskigoran/research/

The undergoing research in my group is concentrated on the development of smart (dynamic) and target-specific (anatomical) contrast agents.

Interaction of the smart agent with ions and molecules involved in the neural signaling should alter its magnetic properties and would permit the translation of the MR signal and visualization of the neural activation. Development of the successful smart functional marker would lead to the introduction of novel type of functional MRI method.

Target-specific contrast agents possess a ligand which specifically binds to the receptor, e.g. genetically engineered protein expressed on the surface of targeted neuronal cells. Selective targeting of neuronal groups may permit the structure-specific monitoring of functional changes with high resolution MRI.

Our main interests are:

  • synthesis of MRI contrast agents; employment of novel synthetic routes in the functionalization and derivatization of macrocyclic carriers for paramagnetic metals.
  • investigation of coordination and physicochemical aspects responsible for the events underlying the change of MR signal.
  • development of methods for in vitro and in vivo characterization of novel probes.

Recent publications:

  • T. Gambino, L. Valencia, P. Pérez-Lourido, D. Esteban-Gómez, M. Zaiss, C. Platas-Iglesias and G. Angelovski. “Inert Macrocyclic Eu3+ Complex with Affirmative paraCEST Features”. Inorg. Chem. Front. 2020, doi: 10.1039/ c9qi01612k. [Paper highlighted on front cover]
  • S. Dobrynin, S. Kutseykin, D. Morozov, O. Krumkacheva, A. Spitsyna, Y. Gatilov, V. Silnikov, G. Angelovski, M. K. Bowman, I. Kirilyuk, A. Chubarov. “Human serum albumin labelled with sterically-hindered nitroxides as potential MRI contrast agents”. Molecules 2020, 25, 1709.
  • G. Gambino, T. Gambino, R. Pohmann, G. Angelovski. “Ratiometric 19F MR-based Method for Quantification of Ca2+ Using Responsive Paramagnetic Probes”. Chem. Commun. 2020, 56, 3492-3495. [Paper highlighted on back cover]
  • F. Garello, S. Gündüz, S. Vibhute, G. Angelovski, E. Terreno. “Dendrimeric calcium-sensitive MRI probes: the first low-field relaxometric study” J. Mater. Chem. B, 2020, 8, 969-979.
  • Đ. Toljić, G. Angelovski. “Translating a low-molecular-weight MRI probe sensitive to amino acid neurotransmitters into a PAMAM dendrimer conjugate: The impact of conjugation”. ChemNanoMat 2019, 5, 1456-1460. [Paper highlighted on front cover]
  • T. Savić, G. Gambino, V. S. Bokharaie, H. R. Noori, N. K. Logothetis, G. Angelovski. “Early detection and monitoring of cerebral ischemia using calcium-responsive MRI probes”. Proc. Natl. Acad. Sci. U.S.A. 2019, 116, 20666-20671.

Curriculum Vitae

1993 - 2000

Chemistry studies, University of Belgrade, Serbia


Diploma in Chemistry, University of Belgrade, Serbia

Diploma thesis. Supervisor: Prof. Dr. Bogdan A. Šolaja. Theme: “Synthesis of Tetraoxane Derivatives of Cholic Acid”

2000 - 2004

PhD studies in Organic Chemistry, University of Dortmund.

Supervisor: Prof. Dr. Peter Eilbracht. Theme: “Synthesis of Azamacrocycles via Sequential Hydroformylation / Reductive Amination and Their Application as Fluorescent Dyes”


PhD in Organic Chemistry, University of Dortmund

2005 - 2013

Research scientist and project leader at the Max Planck Institute for Biological Cybernetics, Department for Physiology of Cognitive Processes. Director: Prof. Dr. Nikos K. Logothetis


Venia legendi (Habilitation) in Organic Chemistry, Faculty of Natural Sciences, University of Tübingen. Habilitation thesis: "Synthesis and Characterization of Lanthanide-based Macrocyclic Complexes for Functional and Dual-modal Imaging."

2014 – Research group leader at the Max Planck Institute for Biological Cybernetics, Research group MR Neuroimaging Agents


2001 - 2004

DAAD PhD fellowship

2009 - 2011

DFG project grant: Design, synthesis and evaluation of smart probes for MRI

2017 - 2019

DFG project grant: Multimeric and nanoscale bioresponsive probes for functional MRI

2019 - 2021

ERA.Net RUS Plus 2017 "S&T" grant: Novel nano-sized biocompatible and stable radical sensors for continuous in vivo hyperpolarization at ultra-low field MRI (NanoHyperRadicals), consortium coordinator

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