Visualizing the multi-scale complexity of the brain
- Date: Oct 11, 2021
- Time: 15:00 - 16:00
- Speaker: Guo-Qiang Bi, PhD
- School of Life Sciences, University of Science and Technology of China & Center for Brain Information, Shenzhen Institute of Advanced Technology
- Location: Zoom
- Host: Jinyou Zou
The brain is complex over multiple length-scales, from many protein molecules forming intricate nano-machines in a synapse to many neurons forming interconnected networks across the brain. Unraveling this multi-scale complexity is fundamental to our understanding of brain function and disease. In this lecture, I will introduce advances in visualizing the complex, multi-scale structures in the brain. Emphasis will be on new imaging techniques, including cryo electron tomography and correlative light-electron microscopy that enabled revealing in situ organization of synaptic molecules, and ultra-high speed volumetric imaging method VISoR developed to map brain-wide circuits at subcellular resolution. I will also discuss challenges and opportunities for interdisciplinary research collaboration to analyze and understand the enormous data generated by these cutting-edge technologies.