Priv.-Doz. Dr. Goran Angelovski

Priv.-Doz. Dr. Goran Angelovski

Research Group Leader
Department Physiology of Cognitive Processes
Research Group MR Neuroimaging Agents (Angelovski)
+49 7071 601 916
+49 7071 601 919
3.A.03

Main Focus

The undergoing research in my group is concentrated on the development of smart (dynamic) and target-specific (anatomical) contrast agents.

Interaction of the smart agent with ions and molecules involved in the neural signaling should alter its magnetic properties and would permit the translation of the MR signal and visualization of the neural activation. Development of the successful smart functional marker would lead to the introduction of novel type of functional MRI method.

Target-specific contrast agents possess a ligand which specifically binds to the receptor, e.g. genetically engineered protein expressed on the surface of targeted neuronal cells. Selective targeting of neuronal groups may permit the structure-specific monitoring of functional changes with high resolution MRI.

Our main interests are:

  • synthesis of MRI contrast agents; employment of novel synthetic routes in the functionalization and derivatization of macrocyclic carriers for paramagnetic metals.
  • investigation of coordination and physicochemical aspects responsible for the events underlying the change of MR signal.
  • development of methods for in vitro and in vivo characterization of novel probes.


Recent publications:

  • T. Savić, G. Gambino, V. S. Bokharaie, H. R. Noori, N. K. Logothetis, G. Angelovski. “Early detection and monitoring of cerebral ischemia using calcium-responsive MRI probes”. Proc. Natl. Acad. Sci. U.S.A. 2019, 116, 20666-20671.

  • Đ. Toljić, G. Angelovski. “A low-molecular weight ditopic MRI probe for ratiometric sensing of zwitterionic amino acid neurotransmitters”. Chem. Commun. 2019, 55, 11924-11927.

  • L. Connah, V. Truffault, C. Platas-Iglesias, G. Angelovski. “Investigations into the Effects of Linker Length Elongation on the Behaviour of Calcium-responsive MRI Probes”. Dalton Trans. 2019, 48, 13546-13554.

  • Đ. Toljić, C. Platas-Iglesias, G. Angelovski. “In-depth study of a novel class of ditopic gadolinium(III)-based MRI probes sensitive to zwitterionic neurotransmitters”. Front. Chem. 2019, 7, 490.

  • L. Connah, R. Joshi, S. Vibhute, G. Gambino, J. D. G. Correia, G. Angelovski. “Solid-Phase-Supported Approach for the Preparation of Bioresponsive and Multifunctional MRI Probes”. Org. Lett. 2019, 21, 5378-5382.

  • F. Oukhatar, S. Eliseeva, C. Bonnet, M. Placidi, N. K. Logothetis, S. Petoud, G. Angelovski, E. Toth. “Towards MRI and Optical Detection of Zwitterionic Neurotransmitters: Near-Infrared Luminescent and Magnetic Properties of Macrocyclic Lanthanide(III) Complexes Appended with a Crown Ether and a Benzophenone Chromophore”. Inorg. Chem. 2019, 58, 13619-13630.

Curriculum Vitae



1993 - 2000

Chemistry studies, University of Belgrade, Serbia

2000

Diploma in Chemistry, University of Belgrade, Serbia

Diploma thesis. Supervisor: Prof. Dr. Bogdan A. Šolaja. Theme: “Synthesis of Tetraoxane Derivatives of Cholic Acid”

2000 - 2004

PhD studies in Organic Chemistry, University of Dortmund.

Supervisor: Prof. Dr. Peter Eilbracht. Theme: “Synthesis of Azamacrocycles via Sequential Hydroformylation / Reductive Amination and Their Application as Fluorescent Dyes”

2004

PhD in Organic Chemistry, University of Dortmund

2005 - 2013

Research scientist and project leader at the Max Planck Institute for Biological Cybernetics, Department for Physiology of Cognitive Processes. Director: Prof. Dr. Nikos K. Logothetis

2012

Venia legendi (Habilitation) in Organic Chemistry, Faculty of Natural Sciences, University of Tübingen. Habilitation thesis: "Synthesis and Characterization of Lanthanide-based Macrocyclic Complexes for Functional and Dual-modal Imaging."

2014 – Research group leader at the Max Planck Institute for Biological Cybernetics, Research group MR Neuroimaging Agents




Grants




2001 - 2004

DAAD PhD fellowship

2009 - 2011

DFG project grant: Design, synthesis and evaluation of smart probes for MRI

2017 - 2019

DFG project grant: Multimeric and nanoscale bioresponsive probes for functional MRI

2019 - 2021

ERA.Net RUS Plus 2017 "S&T" grant: Novel nano-sized biocompatible and stable radical sensors for continuous in vivo hyperpolarization at ultra-low field MRI (NanoHyperRadicals), consortium coordinator



Memberships




German Chemical Society (GDCh)

American Chemical Society (ACS)

Serbian Chemical Society

European Society for Molecular Imaging (ESMI)

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