HPA axis and the slow timescale dynamics of psychiatric disorders

  • Datum: 31.10.2019
  • Uhrzeit: 11:15 - 12:15
  • Vortragende(r): Omer Karin
  • Weizmann Institute of Science, Rehovot, Israel
  • Ort: Max Planck House
  • Raum: room 203
  • Gastgeber: Peter Dayan
HPA axis and the slow timescale dynamics of psychiatric disorders

The stress response is an adaptive response to physical and psychological challenges. It is mediated by a hormonal circuit known as the hypothalamic-pituitary-adrenal (HPA) axis. The HPA axis controls multiple behavioral and physiological end points over several timescales, and the dysregulation of the HPA axis is a hallmark of psychiatric disorders including major depression and addiction. Understanding the stress response and these disorders would benefit from a theoretical framework to unify the dynamical and behavioral features of the HPA axis. We address this by presenting a dynamical model of HPA-axis activity over the timescale of weeks to months. The model incorporates regulation of tissue dynamics by hormones, co-regulation of ACTH and endogenous opioids, and glucocorticoid feedback through several receptor types. Our model can explain dynamical aspects of HPA axis dysregulation that are observed in psychiatric disorders, including alcohol abuse, anorexia nervosa, and depression, as well as slow dynamics of addiction and withdrawal.

Zur Redakteursansicht