Looking for Participants

The MPI for Biological Cybernetics is looking for participants for some of their research experiments [more].
 

Most recent Publications

Grassi PR, Zaretskaya N and Bartels A (February-2017) Scene segmentation in early visual cortex during suppression of ventral stream regions NeuroImage 146 71–80.
Zaldivar D, Logothetis NK and Goense J: Pharmaco-Based fMRI and Neurophysiology in Non-human Primates, -. In: In Vivo Neuropharmacology and Neurophysiology, (Ed) A. Philippu, Springer, Humana Press, New York, NY, USA, (2017).
Fischer DB, Boes AD, Demertzi A, Evrard HC, Laureys S, Edlow BL, Liu H, Saper CB, Pascual-Leone A, Fox MD and Geerling JC (December-2016) A human brain network derived from coma-causing brainstem lesions Neurology 87(23) 2427-2434.
Sahib AK, Mathiak K, Erb M, Elshahabi K, Klamer S, Scheffler K, Focke NK and Ethofer T (December-2016) Effect of temporal resolution and serial autocorrelations in event-related functional MRI Magnetic Resonance in Medicine 76(6) 1805–1813.
Schreiner SJ, Kirchner T, Wyss M, Van Bergen JMG, Quevenco FC, Steiniger SC, Griffith EY, Meier I, Michels L, Gietl A, Leh SE, Brickman AM, Hock C, Nitsch RM, Pruessmann KP, Henning A and Unschuld PG (December-2016) Low episodic memory performance in cognitively normal elderly subjects is associated with increased posterior cingulate gray matter N-acetylaspartate: A 1H MRSI Study at 7 Teslas Neurobiology of Aging 48 195–203.

 

The Research Groups and their Research Focus

Sensorimotor Learning and Decision-Making

Emmy Noether group Braun
One of the most striking features that sets human motor control apart from its robotic counterparts is the remarkable adaptability that allows us to cope with a vast range of complex and variable environments. The research goal of our group is to investigate the computational and biological principles underlying this unrivalled adaptability both experimentally and theoretically.  [more]

Computational Neuroanatomy

One key challenge in neuroscience is to elucidate mechanistic principles of how the brain integrates sensory information from its environment to generate behavior. At present, experimental methods to directly monitor sensory-evoked streams of excitation throughout the brain, at cellular and millisecond resolution are lacking. To overcome these limitations, the ‘Computational Neural Anatomy Group’ seeks to develop an alternative reverse engineering approach. The novel approach comprises reconstructing the detailed 3D structure of neural circuits, quantifying local and long-range synaptic connectivity and simulating sensory-evoked signal flow within the resultant anatomically realistic network models. Opens internal link in current window[more]

MR Spectroscopy and Ultra-High Field Methodology

Magnetic Resonance Spectroscopy (MRS) allows for non-invasive and non-ionizing determination of tissue concentrations and metabolic turn-over rates of various metabolites and compounds in animals or humans. MRS is hence applied for clinical diagnostics and has established as an important tool for physiological research. The focus of this research group is MRS methods development exploiting the advantages of ultra-high field strength and applications in the areas of psychiatric imaging and spinal cord pathologies.Opens internal link in current window[more]

MR Neuroimaging Agents

We develop responsive or smart contrast agents for tracking neuronal activity. These are bioactivated molecules able to detect changes in concentration of ions or molecules relevant for brain function and translate them into changes in MR contrast. These functional markers permit direct visualization of neural activation independent of the state of the vascular system. Opens internal link in current window[more]

Translational Neuroimaging and Neural Control

One research direction is to study the underlying mechanism of neurovascular coupling by identifying the signaling molecules propagating from neuron to glia, and to vessel. The other is to identify the “core switch” underlying the brain arousal and coma states by combining genetic tools with optical imaging and high field fMRI. The goal is to identify candidate molecules from critical brain nuclei, which can contribute to switch brain states. We are expected to translate the knowledge acquired from animal models to novel therapeutic treatment of coma patients. Opens internal link in current window[more]

Space and Body Perception

Our aim is to investigate human perception and behavior using ecologically valid and immersive virtual reality (VR). At the same time we consider the implications of our scientific results for improving design specifications for VR software and technology. VR equipment enables our scientists to provide sensory stimulus in a controlled virtual world and to manipulate or alter sensory input that would not be possible in the real world. Opens internal link in current window[more]

Neuronal Convergence

fMRI is widely used to study the operational organization of the brain. The exact relationship between the measured functional signal and the underlying neural activity, however, is yet unclear. Previous studies (Logothetis et al., 2001; Caesar et al., 2003) have already exam-
ined the relationship between large-scale electrical (in particular the local field potentials) and functional activity patterns. However, the large-scale neurochemical context, which is of utmost importance for drug design and development, has so far not been considered. [more]
Last updated: Friday, 14.10.2016