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Imaging in awake

Imaging activity from neuronal populations using a combination of Opens external link in new windowmulti-photon imaging, targeted electrophysiology, and calcium indicators affords several advantages over traditional activity recording techniques.

Multi-photon imaging of neuronal activity, not only provides spatial resolution and morphological identification, but also spike activity detection in all neurons within the imaging area, even those that respond at low rates or respond infrequently. This allows both a complete picture to be formed of the local circuit and quantification ofOpens external link in new window higher-order statistics across the population. Population imaging allows the simultaneous mapping of the receptive-fields of many identified neurons and, even more importantly, the detection of activity correlations in neuronal activity that can be related back to spatial location and cell type. The development of genetically encoded calcium indicators (GECIs) allows the same neuronal populations to be imaged over months during the learning process.

Last updated: Thursday, 05.07.2012