Looking for Participants

The MPI for Biological Cybernetics is looking for participants for some of their research experiments [more].

Most recent Publications

Fichtner ND, Giapitzakis I-A, Avdievich N, Mekle R, Zaldivar D, Henning A and Kreis R (June-2018) In vivo characterization of the downfield part of 1H MR spectra of human brain at 9.4T: Magnetization exchange with water and relation to conventionally determined metabolite content Magnetic Resonance in Medicine 79(6) 2863-2873.
Göksu C, Hanson LG, Siebner HR, Ehses P, Scheffler K and Thielscher A (May-2018) Human in-vivo brain magnetic resonance current density imaging (MRCDI) NeuroImage 171 26-39.
Celicanin Z, Manasseh G, Petrusca L, Scheffler K, Auboiroux V, Crowe LA, Hyacinthe JN, Natsuaki Y, Santini F, Becker CD, Terraz S, Bieri O and Salomir R (May-2018) Hybrid ultrasound-MR guided HIFU treatment method with 3D motion compensation Magnetic Resonance in Medicine 79(5) 2511-2523.
Schindler A and Bartels A (May-2018) Integration of visual and non-visual self-motion cues during voluntary head movements in the human brain NeuroImage 172 597-607.
Pracht ED, Feiweier T, Ehses P, Brenner D, Roebroeck A, Weber B and Stöcker T (May-2018) SAR and scan-time optimized 3D whole-brain double inversion recovery imaging at 7T Magnetic Resonance in Medicine 79(5) 2620–2628.


Chemistry and Biology Laboratories

For the synthesis of smart contrast agents several highly equipped laboratories are available in the Magnetic Resonance Center (MRC) and in the neighbouring Technologiepark building.

The chemical laboratories are equipped with all routine tools for chemical synthesis (hoods, hydrogenation apparatus, freeze dryer etc.). Two manual as well as a fully automated peptide synthesizers for solid phase synthesis of cell penetrating peptides and peptide nucleic acids can be used. The analytical laboratories house a LC-MS unit (ESI ionization) and two systems for analytical and preparative HPLC, a fluorescence/luminescence spectrometer as well as a 300 MHz (7T) NMR spectrometer.

The cell biology laboratories are equipped for cell culture work with two laminar flow, two CO2-incubators, and a routine inverse brightfield microscope with fluorescence unit and camera. Two research microscopes are also available. One is based on extreme darkfield microscopy optimized for real time life cell imaging and is connected to a high resolution colour video camera. The other inverse microscope is equipped with an optical grid, motorized focus and a high end black-and-white digital camera. It allows the recording and reconstruction of high resolution 3D fluorescence images from cells or tissue slices. Both microscopes are used to study uptake mechanism, fate and intracellular localization of contrast agents. The labs are used to perform various kinds of cell biological assays and are equipped e.g. with centrifuges, electrophoresis units and a multiplate reader primarily used for absorption and fluorescence spectroscopic studies on the internalization of the contrast agents into cells as well as on their biocompatibility.
A second laboratory provides all required safety features to work with radioisotopes.
Last updated: Friday, 14.10.2016