Looking for Participants

The MPI for Biological Cybernetics is looking for participants for some of their research experiments [more].
 

Most recent Publications

Göksu C, Hanson LG, Siebner HR, Ehses P, Scheffler K and Thielscher A (May-2018) Human in-vivo brain magnetic resonance current density imaging (MRCDI) NeuroImage 171 26-39.
Nassirpour S, Chang P, Fillmer A and Henning A (February-2018) A comparison of optimization algorithms for localized in vivo B0 shimming Magnetic Resonance in Medicine 79(2) 1145–1156.
Cleij D, Venrooij J, Pretto P, Pool DM, Mulder M and Bülthoff HH (February-2018) Continuous Subjective Rating of Perceived Motion Incongruence During Driving Simulation IEEE Transactions on Human-Machine Systems 48(1) 17-29.
Avdievich NI, Giapitzakis I-A, Pfrommer A and Henning A (February-2018) Decoupling of a tight-fit transceiver phased array for human brain imaging at 9.4T: Loop overlapping rediscovered Magnetic Resonance in Medicine 79(2) 1200–1211.
Arena C, Irrera P, Consolino L, Colombo Serra S, Zaiss M and Longo DL (February-2018) Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging Journal of Magnetic Resonance 287 1–9.

 

Chemistry and Biology Laboratories

For the synthesis of smart contrast agents several highly equipped laboratories are available in the Magnetic Resonance Center (MRC) and in the neighbouring Technologiepark building.

The chemical laboratories are equipped with all routine tools for chemical synthesis (hoods, hydrogenation apparatus, freeze dryer etc.). Two manual as well as a fully automated peptide synthesizers for solid phase synthesis of cell penetrating peptides and peptide nucleic acids can be used. The analytical laboratories house a LC-MS unit (ESI ionization) and two systems for analytical and preparative HPLC, a fluorescence/luminescence spectrometer as well as a 300 MHz (7T) NMR spectrometer.

The cell biology laboratories are equipped for cell culture work with two laminar flow, two CO2-incubators, and a routine inverse brightfield microscope with fluorescence unit and camera. Two research microscopes are also available. One is based on extreme darkfield microscopy optimized for real time life cell imaging and is connected to a high resolution colour video camera. The other inverse microscope is equipped with an optical grid, motorized focus and a high end black-and-white digital camera. It allows the recording and reconstruction of high resolution 3D fluorescence images from cells or tissue slices. Both microscopes are used to study uptake mechanism, fate and intracellular localization of contrast agents. The labs are used to perform various kinds of cell biological assays and are equipped e.g. with centrifuges, electrophoresis units and a multiplate reader primarily used for absorption and fluorescence spectroscopic studies on the internalization of the contrast agents into cells as well as on their biocompatibility.
A second laboratory provides all required safety features to work with radioisotopes.
Last updated: Friday, 14.10.2016