Looking for Participants

The MPI for Biological Cybernetics is looking for participants for some of their research experiments [more].

Most recent Publications

Zaiss M, Schuppert M, Deshmane A, Herz K, Ehses P, Füllbier L, Lindig T, Bender B, Ernemann U and Scheffler K (October-2018) Chemical exchange saturation transfer MRI contrast in the human brain at 9.4 T NeuroImage 179 144-155.
Loktyushin A, Ehses P, Schölkopf B and Scheffler K (September-2018) Autofocusing-based phase correction Magnetic Resonance in Medicine 80(3) 958-968.
Gärtner M, Ghisu ME, Scheidegger M, Bönke L, Fan Y, Stippl A, Herrera-Melendez AL, Metz S, Winnebeck E, Fissler M, Henning A, Bajbouj M, Borgwardt K, Barnhofer T and Grimm S (August-2018) Aberrant working memory processing in major depression: evidence from multivoxel pattern classification Neuropsychopharmacology 43(9) 1972-1979.
Giapitzakis IA, Avdievich NI and Henning A (August-2018) Characterization of macromolecular baseline of human brain using metabolite cycled semi-LASER at 9.4T Magnetic Resonance in Medicine 80(2) 462-473.
Chang P, Nassirpour S, Eschelbach M, Scheffler K and Henning A (August-2018) Constrained optimization for position calibration of an NMR field camera Magnetic Resonance Imaging 80(1) 380-390.


With imaging techniques, such as electroencephalography (EEG), magnetoenzophalography (MEG) or functional magnetic resonance imaging (fMRI) the processes in the brain can be investigated. Brain activity can be recorded even directly or indirectly and interpreted by a computer system.

Brain Imaging Facilities

Ultra High-Field MRI systems

Siemens 9.4 whole body system
14.2 T small animal system
9.4 T MR whole body system
In operation since July 2007, this scanner is the third MR system worldwide with this field strength, the first in Europe and the first 9.4 T scanner built by Siemens. The magnet itself weighs 48 tons and the bore diameter is 82 cm without the gradient coil required for spatial encoding. It has a usable bore size of 60 cm and a head gradient with a maximum gradient strength of 60 mT/m and a slew rate of 400 T/m/s. Its length is almost 4 m and it is placed inside a cage consisting of 600 tons of steel for shielding the magnetic field. This scanner is equipped with a broadband amplifier for multi-nuclei excitation. Hardware for excitation and acquisition, like rf-coils and preamplifiers, are designed and built in our institute.
14.2 T small animal system
This scanner was delivered in August 2007. With a field strength of 14.2 T and a free bore size of 12 cm, it has the strongest horizontal MR magnet worldwide. The 25 tons magnet with 26 cm bore is accommodated in a 220 tons tempered steel enclosure to shield the stray field. It was built by Magnex Scientific (Oxford, UK), the MR hardware was delivered by Bruker Biospin in Karlsruhe. The system is equipped with gradients with a strength of 1 T/m and a high-performance shim system with dynamic shim capacities. State-of-the-art animal handling and supervision equipment is used to prepare the animals for the experiments, to ensure their well-being during anaesthesia and to monitor their physiological parameters during the measurements.

3 Tesla MRI whole body system

Siemens 3T whole body system
A Siemens Magnetom Prisma research system with a magnetic field strength of 3 T and a bore diameter of 60 cm was delivered in July 2006. This scanner is mainly used for functional imaging studies performed by groups of our institute as well as external collaborators. It is capable of signal reception on 32 channels simultaneously for parallel imaging and is equipped with 40mT/m gradients with a slew rate of 200 T/m/s. In addition, the scanner has a secondary broadband amplifier for excitation of nuclei other than protons.

Low Field MRI

Another area of interest at the MRZ is ultralow-field magnetic resonance imaging (ULF MRI). For studies on phantoms and small animals, a ULF MRI laboratory is installed since 2015. In contrast to conventional or high-field MRI no helium cooled magnet is needed. Instead a helium cooled SQUID (Superconducting QUantum Interference Device) based broadband detector is used, which is extremely sensitive. Therefore, the ULF MRI system sits inside a three layered shielding chamber, which is capable of shielding low and high frequency noise sources.

The ULF MRI system was designed within the Department for High field Magnetic resonance from the research group for Ultralow Field Magnetic Resonance Imaging. It was fabricated by the internal mechanics workshop. The system is also equipped with home-made amplifiers, fabricated by the electronics workshop.

Until now, novel hyperpolarization techniques are investigated, which may enable high resolution imaging at ULF. The necessary sequences are programed via Labview and the signals are fed into the amplifier with a National Instruments PXIe system.

Coil Laboratory

Coil Laboratory
Experiments with the ultra-high-field scanners are enabled by homebuilt rf-coils, preamplifiers and T/R-switches. This hardware is designed and constructed in our coil laboratory, equipped with two network analysers, a noise figure analyser, a spectrum analyser and a shielded box for noise figure measurements.

In addition, several software Packages for simulation of coils (XFDTD, Remcom; SEMCAD, Speag; Microwave Studio, CST) and preamplifiers (Microwave Office, Applied Wave Research, El Segundo, CA, USA) are available.
Last updated: Wednesday, 30.05.2018