Contact

Yibin Shao

Address: Spemannstr. 38
72076 Tübingen
Room number: 234
Phone: +49 7071 601 696
Fax: +49 7071 601 652
E-Mail: yibin.shao

 

Picture of Shao, Yibin

Yibin Shao

Position: PhD Student  Unit: Alumni Logothetis

Visual cortical plasticity after V1 lesion and retina degeneration in macaque monkeys

 

Introduction and Scientific Aims

Primate visual cortex (V1) is of particular interest as it is the main cortical relay of visual information. It is not surprising that primary visual cortical injuries produce a dense visual scotoma that has long been thought to be irreversible. However, a series of studies performed over the last 25 years has provided strong evidence that primate (human and monkey) subjects still possess some rudimentary residual visual sensitivity in the blind part of their visual field following dense area V1 lesions (blindsight) [1-3]. Macular degeneration (MD) is a common cause of human visual impairment, which often damages the central retina eliminating the normal retinal input to a large region of visual cortex. Human fMRI studies in MD patients and electrophysiological studies in macaques with retinal lesions indicate that V1 might retain a remarkable degree of plasticity into adulthood [4,5]. However a recent fMRI study in rhesus macaques following homonymous retinal lesions suggested that post lesion responses inside the V1 lesion projection zone (LPZ) are weak or absent [6].

The purpose of our experiments is to study how the visual cortex changes to adapt to injury, with particular focus on understanding aspects of plasticity that may help us restore part of the loss functionality.

 

Methods

We are using fMRI methods to study reorganization in the primary visual cortex of one animal with macular degeneration that was fortuitously found in our colony. We also plan to employ electrophysiological recording and stimulation techniques in the non-human primate to study visual cortex reorganization following area V1 lesions.

 

Results and Preliminary Conclusions

For the macular degeneration monkey (D06), the size and location of the fMRI defined LPZ in V1 is consistent with the retinotopic projection of the retinal lesion. The retinotopic organization of the non-deafferented V1 periphery is regular without distortion. Higher level visual areas of D06 (V5/MT) show more extensive activation than areas of control monkeys with an artificial scotoma (to obscure part of the stimuli from the visual field as a simulation of the real scotoma) of comparable size. Population receptive field sizes in the non-deafferented V5/MT of monkey D06 are on average slightly smaller than controls.No significant activity was found within V1 LPZ of D06. There is potential reorganization in V5/MT of this monkey.

 

References

1. Cowey A and Stoerig P (1995) blindsight in monkeys. Nature,373(6511): p. 247-9.

2. Huxlin KR, Martin T, Kelly K, Riley M, Friedman DI, Burgin WS and Hayhoe M (2009) perceptual Relearning of Complex Visual Motion after V1 Damage in Humans. J Neurosci, 29(13):3981-3991

3. Schmid MC, Panagiotaropoulos T, Augath M, Logothetis N K and Smirnakis SM (2009) visually driven activation in macaque areas V2 and V3 without input from the primary visual cortex. PLoS ONE, 4, e5527.

4. Baker C I, Peli E, Knouf N and Kanwisher NG (2005) reorganization of visual processing in macular degeneration. J. Neurosci. 25, 614–618.

5. Gilbert CD and Wiesel TN (1992) receptive field dynamics in adult primary visual cortex. Nature 356, 150–-152.

6. Smirnakis SM, Brewer AA, Schmid MC, Tolias AS, Schüz A, Augath M, Inhoffen W, Wandell BA and Logothetis NK (2005) lack of long-term cortical reorganization after macaque retinal lesions. Nature 435, 300–307.

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Articles (3):

Papanikolaou A, Keliris GA, Papageorgiou TD, Shao Y, Krapp E, Papageorgiou E, Stingl K, Bruckmann A, Schiefer U, Logothetis NK and Smirnakis SM (April-2014) Population receptive field analysis of the primary visual cortex complements perimetry in patients with homonymous visual field defects Proceedings of the National Academy of Sciences of the United States of America 111(16) E1656–E1665.
Shao Y, Keliris GA, Papanikolaou A, Fischer MD, Zobor D, Jägle H, Logothetis NK and Smirnakis SM (November-2013) Visual cortex organisation in a macaque monkey with macular degeneration European Journal of Neuroscience 38(10) 3456–3464.
Fischer MD, Zobor D, Keliris GA, Shao Y, Seeliger MW, Haverkamp S, Jägle H, Logothetis NK and Smirnakis SM (August-2012) Detailed functional and structural characterization of a macular lesion in a rhesus macaque Documenta Ophthalmologica 125(3) 179-194.

Posters (11):

Keliris GA, Shao Y, Papanikolaou A, Logothetis NK and Smirnakis M (November-13-2013): Estimation of average single-unit receptive field size by fMRI, 43rd Annual Meeting of the Society for Neuroscience (Neuroscience 2013), San Diego, CA, USA.
Shao Y, Keliris GA, Schmid MC, Papanikolaou A, Logothetis NK and Smirnakis SM (November-9-2013): Population receptive field measurements in the visual cortex of macaque monkeys with and without retinal lesions, 43rd Annual Meeting of the Society for Neuroscience (Neuroscience 2013), San Diego, CA, USA.
Smirnakis SM, Keliris GA, Shao Y, Papanikolaou A and Logothetis NK (August-2012): Population receptive field measurements in macaque visual cortex, 12th Annual Meeting of the Vision Sciences Society (VSS 2012), Naples, FL, USA, Journal of Vision, 12(9) 1397.
Papanikolaou A, Keliris GA, Papageorgiou DT, Shao Y, Krapp E, Schiefer U, Logothetis N and Smirnakis SM (June-2012): Population Receptive Field Mapping in Human Subjects after Lesions of the Visual Pathway, AREADNE 2012: Research in Encoding and Decoding of Neural Ensembles, Santorini, Greece.
Shao Y, Keliris GA, Papanikolaou A, Fischer DM, Nagy D, Jaegle H, Augath M, Logothetis NK and Smirnakis SM (June-2012): Population receptive field measurements in the visual cortex of macaque monkeys with and without retinal lesions, AREADNE 2012: Research in Encoding and Decoding of Neural Ensembles, Santorini, Greece.
Papanikolaou A, Keliris GA, Shao Y, Krapp E, Papageorgiou E, Schiefer U, Logothetis NK and Smirnakis SM (November-2011): Population receptive field mapping in human subjects with lesions of the visual cortex, 41st Annual Meeting of the Society for Neuroscience (Neuroscience 2011), Washington, DC, USA.
Shao Y, Keliris GA, Papanikolaou A, Augath M, Logothetis NK and Smirnakis SM (November-2011): Population receptive field measurements in visual cortex of macaque monkeys, 41st Annual Meeting of the Society for Neuroscience (Neuroscience 2011), Washington, DC, USA.
Papanikolaou A, Keliris G, Shao Y, Krapp E, Schiefer U, Logothetis NK and Smirnakis S (October-2011): Population receptive field mapping in human subjects with visual cortical lesions, 12th Conference of Junior Neuroscientists of Tübingen (NeNA 2011), Heiligkreuztal, Germany.
Keliris GA, Shao Y, Papanikolaou A, Peng X, Logothetis NK and Smirnakis SM (November-2010): Assessing the spatio-temporal dynamics of visual receptive fields by fMRI, 40th Annual Meeting of the Society for Neuroscience (Neuroscience 2010), San Diego, CA, USA.
Shao Y, Keliris GA, Papanikolaou A, Fischer DM, Nagy D, Jägle H, Seeliger MW, Augath M, Logothetis NK and Smirnakis SM (November-2010): Population receptive field mapping in a macaque monkey with macular degeneration, 40th Annual Meeting of the Society for Neuroscience (Neuroscience 2010), San Diego, CA, USA.
Papanikolaou A, Keliris GA, Peng X, Shao Y, Krapp E, Papageorgiou E, Schiefer U, Logothetis NK and Smirnakis SM (November-2010): Population receptive field mapping in human subjects with visual cortical lesions, 40th Annual Meeting of the Society for Neuroscience (Neuroscience 2010), San Diego, CA, USA.

Talks (1):

Papanikolaou A, Keliris GA, Papageorgiou GT, Shao Y, Krapp E, Papageorgiou E, Schiefer U, Logothetis NK and Smirnakis SM (November-12-2013) Abstract Talk: Human area V5/MT+ organization changes following lesions of the primary visual cortex, 43rd Annual Meeting of the Society for Neuroscience (Neuroscience 2013), San Diego, CA, USA(602.07).

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Last updated: Monday, 22.05.2017