Contact

Dr. Xin Yu

Address: Spemannstr. 41
72076 Tuebingen
Room number: 4.B.09
Phone: +49 7071 601 740
Fax: +49 7071 601 701
E-Mail: xin.yu

 

Picture of Yu, Xin, Dr.

Xin Yu

Position: Research Group Leader  Unit: Yu Scheffler

One research direction is to study the underlying mechanism of neurovascular coupling by identifying the signaling molecules propagating from neuron to glia, and to vessel. The other is to identify the “core switch” underlying the brain arousal and coma states by combining genetic tools with optical imaging and high field fMRI.  The goal is to identify candidate molecules from critical brain nuclei, which can contribute to switch brain states.  We are expected to translate the knowledge acquired from animal models to novel therapeutic treatment of coma patients.

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EDUCATION

 

2007 Ph.D. of Biophysics, Neuroscience, and Physiology, School of Medicine, New York University, USA

2002 Master of Science, Department of Biology, Seton Hall University, USA

2000 Bachelor of Science, Wuhan University, China

 

RESEARCH EXPERIENCE

 

2014-present  Research Group Leader, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany

2008-2013      Research Fellow, National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, USA

2007-2008      Visiting Postdoctoral Fellow, NIH, NINDS, Bethesda, USA

2002-2007      Research Assistant, Skirball Institute, New York University, New York, USA

2000-2002     Research Assistant/Teaching Assistant, Seton Hall University, South Orange, USA

1998-2000     Research Assistant, Chitin Research Center, Wuhan University, China

 

GRANT-FELLOWSHIP

 

2010-2012 NINDS Competitive Fellowship (equivalent to extramural NRSA): Using MRI to analyze lesion-induced neuroplasticity in rats

 

INVITED TALKS

 

2013    Symposium on High-Field NMR Animal Imaging, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany

2012    Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD, USA

2012    Symposium on Brainnetome Meets Genome, University of Queensland, Queensland Brain Institute/Center for Advanced Imaging, Brisbane, Australia,

2011    Peking University, Dept of Biomedical Engineering, Beijing, China

2011    New York University, School of Medicine, Center for Biomedical Imaging, New York, USA

2011    Biomedical Imaging Research Seminar, Weill Medical College of Cornell University, New York, USA

2010    Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China 2010

2009    Educational Courses of International Society of Magnetic Resonance in Medicine (ISMRM): MRI/MRS of mice.  Honolulu, USA

2008    Gordon Research Conference (Auditory system). New London, USA

 

HONORS AND AWARDS

 

2013  Summa Cum Laude Merit Award (ISMRM), Salt Lake City, USA

2012  Summa Cum Laude Merit Award (ISMRM), Melbourne, Australia

2012  Invited Moderator of the Sunshine Educational Course of ISMRM, Melbourne, Australia

2011  Junior Fellow of the ISMRM

2007  Second Place Poster Award of ISMRM, Berlin, Germany

2007  Banner Bearer of Graduate School of Arts and Sciences of NYU, USA

2007  President’s Service Award (NYU), USA

2005  Philipson Speaker Award (Skirball Institute Annual Retreat), USA

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Articles (17):

Chung S, Jeong J-H, Ko S, Yu X, Kim Y-H, Isaac JTR and Koretsky AP (June-2017) Peripheral Sensory Deprivation Restores Critical-Period-like Plasticity to Adult Somatosensory Thalamocortical Inputs Cell Reports 19(13) 2707–2717.
Pais-Roldán P, Singh AP, Schulz H and Yu X (April-2016) High magnetic field induced otolith fusion in the zebrafish larvae Scientific Reports 6(24151) 1-11.
Yu X, He Y, Wang M, Merkle H, Dodd SJ, Silva AC and Koretsky AP (April-2016) Sensory and optogenetically driven single-vessel fMRI Nature Methods 13(4) 337-340.
Yu X and Koretsky AP (November-2014) Interhemispheric plasticity protects the deafferented somatosensory cortex from functional takeover after nerve injury Brain Connectivity 4(9) 709-717.
Quian C, Yu X, Pothayee N, Dodd S, Bouraoud N, Star RA, Bennett KM and Koretsky N (November-2014) Live nephron imaging by MRI American Journal of Physiology - Renal Physiology 307(10) F1162-F1168.
Yu X, Qian C, Chen D-Y, Dodd SJ and Koretsky AP (January-2014) Deciphering laminar-specific neural inputs with line-scanning fMRI Nature Methods 11(1) 55-58.
Qian C, Yu X, Chen D-Y, Dodd S, Bouraoud N, Pothayee N, Chen Y, Beeman S, Bennett K, Murphy-Boesch J and Koretsky a (July-2013) Wireless Amplified NMR detector (WAND) for high resolution in-vivo image of internal organs Radiology 268(1) 228-236.
Yu X, Chung S, Chen D-Y, Wang S, Dodd SJ, Walters JR, Isaac JTR and Koretsky AP (May-2012) Thalamocortical inputs show post-critical-period plasticity Neuron 74(4) 731–742.
Yu X, Glen D, Wang S, Dodd S, Hirano Y, Silva AC and Koretsky AP (February-2012) Direct imaging of macrovascular and microvascular contributions to BOLD fMRI in layers IV–V of the rat whisker–barrel cortex NeuroImage 59(2) 1451–1460.
Yu X, Nieman BJ, Sudarov A, Szulc KU, Abdollahian DJ, Bhatia N, Lalwani AK, Joyner AL and Turnbull DH (June-2011) Morphological and functional midbrain phenotypes in Fibroblast Growth Factor 17 mutant mice detected by Mn-enhanced MRI NeuroImage 56(3) 1251–1258.
Yu X, Wang S, Chen D-Y, Dodd S, Goloshevsky A and Koretsky AP (January-2010) 3D mapping of somatotopic reorganization with small animal functional MRI NeuroImage 49(2) 1667–1676.
Yu X, Zou J, Babb JS, Johnson G, Sanes DH and Turnbull DH (January-2008) Statistical mapping of sound-evoked activity in the mouse auditory midbrain using Mn-enhanced MRI NeuroImage 39(1) 223–230.
Yu X, Sanes DH, Aristizabal O, Wadghiri YZ and Turnbull DH (July-2007) Large-scale reorganization of the tonotopic map in mouse auditory midbrain revealed by MRI Proceedings of the National Academy of Sciences of the United States of America 104(29) 12193–12198.
Deans AE, Wadghiri YZ, Bernas LM, Yu X, Rutt BK and Turnbull DH (July-2006) Cellular MRI contrast via coexpression of transferrin receptor and ferritin Magnetic Resonance in Medicine 56(1) 51–59.
Yu X, Wadghiri YZ, Sanes DH and Turnbull DH (July-2005) In vivo auditory brain mapping in mice with Mn-enhanced MRI Nature Neuroscience 8(7) 961-968.
Wadghiri YZ, Blind JA, Duan X, Moreno C, Yu X, Joyner AL and Turnbull DH (December-2004) Manganese-enhanced magnetic resonance imaging (MEMRI) of mouse brain development NMR in Biomedicine 17(8) 613–619.
Yu X, Mao X, Blake AD, Li WX and Chang SL (August-2003) Morphine and Endomorphins Differentially Regulate μ-Opioid Receptor mRNA in SHSY-5Y Human Neuroblastoma Cells Journal of Pharmacology and Experimental Therapeutics 306(2) 447-454.

Conference papers (1):

Yu X and Turnbull DH (November-2004) Mn-enhanced MRI for Functional Neuroimaging in Mice, Fifth Annual Conference for Young Scientists of the China Association for Science and Technology (CAST 2004), Science Press, Beijing, China, 66-76.

Contributions to books (1):

Yu X: When Photons Meet Protons: Optogenetics, Calcium Signal Detection, and fMRI in Small Animals, 773-791. In: Small Animal Imaging: Basics and Practical Guide, (Ed) F. Kiessling, Springer, Cham, Switzerland, (May-2017).

Posters (22):

Schluesener J and Yu X (April-27-2017): Deciphering the functional projections of the lateral hypothalamus with optogenetic fMRI, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
He Y, Wang M, Chen X and Yu X (April-27-2017): Identify the neural basis of vascular dynamic network connectivity with high-field fMRI, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Chen Y, Pais-Roldán P, Chen X and Yu X (April-26-2017): Stepwise optogenetic activation of the rat thalamic nuclei with MRI-guided robotic arm (MgRA), 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Wang M, He Y and Yu X (April-25-2017): A novel role of intrinsic astrocytic calcium spikes to mediate brain states through central/dorsal thalamic nuclei, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Chen Y, Sobczak F and Yu X (May-11-2016): MRI-guided robotic arm (MgRA) to target deep brain nuclei in vitro, 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016), Singapore.
Pais Roldán P, Edlow B and Yu X (May-9-2016): Developing a Rat Model of Brainstem Coma: Initial MRI and MRA Investigations of Basilar Artery Occlusion, 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016), Singapore.
Scheffler K, Ehses P, He Y, Merkle H and Yu X (June-3-2015): Functional imaging at 14.1T using high-resolution pass band bSSFP, 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.
Wang M, He Y, Tang Y, Merkle H and Yu X (June-3-2015): Identify the “single unit” of neurovascular coupling by single-vessel fMRI and optogenetics, 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.
Wang M, He Y, Tang Y, Balla DZ, Qian C and Yu X (June-3-2015): Map the light-driven fMRI signal in combination with in vivo recording, 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.
He Y, Zhang K and Yu X (June-2-2015): Model the single-venule fMRI signal at the millisecond scale, 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.
Wang M, He Y, Tang Y, Balla D and Yu X (March-19-2015): Light-driven fMRI and Electrophysiological Responses in Rat Brain, 10th Annual Meeting of the European Society for Molecular Imaging (EMIM 2015), Tübingen, Germany.
Pais Roldán P, Singh A, Merkle H, Schulz H and Yu X (March-19-2015): Magnetic field-induced otolith fusion of the zebrafish larvae, 10th Annual Meeting of the European Society for Molecular Imaging (EMIM 2015), Tübingen, Germany.
Yu X, Porter B, Dodd S, Silva A and Koretsky A (May-10-2012): Direct Imaging of Distinct Vascular Elements Detected by BOLD and Iron Oxide Based Blood Volume Using High Resolution fMRI of the Rodent Whisker Barrel, 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia.
Yu X, Dodd S, Silva A and Koretsky A (May-9-2011): Direct Imaging of Microvascular and Macrovasular contributions by Time Resolved BOLD fMRI Allows Better Separation of Whisker Rows in the Rodent Barrel Cortex, 19th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2011), Montréal, Canada.
Yu X, Goloshevsky A, Dodd S, Silva A and Koretsky A (April-23-2009): High Resolution BOLD-fMRI of the Auditory System in Rats, 17th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2009), Honolulu, HI, USA.
Yu X, Sanes D, Zou J and Turnbull DH (February-6-2006): Early Developmental Tonotopic Mapping of the Mouse Auditory Midbrain with Mn-Enhanced MRI, 29th Annual MidWinter Meeting of the Association for Research in Otolaryngology (ARO 2006), Baltimore, MD, USA.
Dean AE, Yu X, Wadghiri YZ, Duan XC and Turnbull DH (May-11-2005): 7T-MRI of Transferrin Receptor and Ferritin Gene Expression in a Mouse Neural Stem Cell Line, 13th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2005), Miami Beach, FL, USA.
Yu X, Wadghiri YZ, Sanes DH and Turnbull DH (October-24-2004): Mn-Enhanced MRI of the tonotopic map in the mouse inferior colliculus, 34th Annual Meeting of the Society for Neuroscience (Neuroscience 2004), San Diego, CA, USA.
Yu X, Wadghiri YZ, Sanes DH and Turnbull DH (July-2004): Mn-enhanced MRI of neural activity in the mouse auditory system, Gordon Research Conference: In Vivo Magnetic Resonance, Lewiston, ME, USA.
Yu X, Wadghiri YZ, Moreno C, Sanes DH and Turnbull DH (November-11-2003): Mn-Enhanced MRI of auditory Activity in the mouse brain, 33rd Annual Meeting of the Society for Neuroscience (Neuroscience 2003), New Orleans, LA, USA.
Wadghiri YZ, Moreno C, Yu X, Joyner AL and Turnbull DH (July-14-2003): Mn-Enhanced MRI of the neonatal mouse brain, 11th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2003), Toronto, Canada.
Yu X, Blake AD, Mao X and Chang SL (November-4-2002): Mu opioid receptor mRNA expression in SHSY-5Y human neuroblastoma cells, 32nd Annual Meeting of the Society for Neuroscience (Neuroscience 2002), Orlando, FL, USA.

Talks (35):

Yu X (September-30-2017) Invited Lecture: Concurrent physiological multi-site calcium recordings and brain imaging: study of dynamic connectivity related to system and fluctuation states, Istituto di Neuroscienze CNR Annual Retreat 2017, Santa Margherita di Pula, Italy.
Yu X (September-24-2017) Invited Lecture: Translational Neuroimaging using High-field fMRI, Workshop "Neuroimaging in CNS Drug Development": Translational Medicine '17, Praha, Czech Republic.
Chen XM, Chen Y and Yu X (April-27-2017) Abstract Talk: Decipher the hippocampal neurovascular coupling with simultaneous fMRI and GCaMP-mediated calcium recording, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA 670.
Chen Y, Schlüsener K and Yu X (April-26-2017) Abstract Talk: MRI-guided robotic arm (MgRA) to target deep brain nuclei in vivo, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA 453-454.
He Y, Pohmann R, Scheffler K, Kleinfeld D, Rosen B and Yu X (April-25-2017) Abstract Talk: Mapping the task-related and resting-state vascular dynamic network connectivity in rats and humans, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA 304-305.
Wang M, He Y and Yu X (April-24-2017) Abstract Talk: Simultaneous fMRI with GCaMP6-mediated neuronal and astrocytic calcium signal recording, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA 122.
Chen X, Chen Y and Yu X (September-8-2016) Abstract Talk: Map optogenetically driven hippocampal activity with simultaneous fMRI and GCaMP-mediated calcium recording, 9th Annual World Molecular Imaging Congress (WMIC 2016), New York, NY, USA, Molecular Imaging and Biology, 18(Supplement 2) S1296-S1297.
Wang M, He Y, Engelmann J and Yu X (September-2016) Abstract Talk: Decipher the neuronal and astrocytic calcium signal coupling with fMRI, 17th Conference of Junior Neuroscientists of Tübingen (NeNa 2016): Neuroscience & Law, Schramberg, Germany 12.
He Y, Pohmann R, Scheffler K, Kleinfeld D, Rosen B and Yu X (September-2016) Abstract Talk: Map task-related and resting-state Vascular Network Connectivity in Rats and Humans, 17th Conference of Junior Neuroscientists of Tübingen (NeNa 2016): Neuroscience & Law, Schramberg, Germany 13.
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Last updated: Monday, 22.05.2017