Contact

Dr. Tingting Shao

Address: Spemannstr. 41
72076 Tübingen
Room number: 4.B.10
Phone: +49 7071 601 731
Fax: +49 7071 601 702
E-Mail: tingting.shao

 

Picture of Shao, Tingting, Dr.

Tingting Shao

Position: Research Scientist  Unit: Henning Scheffler

My research is focused on sequence design for MRS and MRI in human brain at 9.4T, aiming to tackle technical challenges introduced by the ultra-high field and therefore improve image quality and produce reliable image information for clinical diagnosis.

 

Parallel transmit spectral-spatial pulse design for ultra-high field MRS


Ultra high field MRI benefits 1H magnetic resonance spectroscopy (MRS) applications by offering increased chemical shift dispersion, improved SNR and reduced J-coupling, but also raises technical challenges such as shortened T2 and T2* relaxation times, severe chemical shift displacement artifacts and signal disuniformity due to high spatial B1+ field inhomogeneity. In this work, a parallel transmission based pulse design method that combines subspace preconditioned least squares optimization (LSQR) and optimal control (OC) approaches is proposed to achieve spectral-spatial pulses (SPSP) that tackle aforementioned technical challenges in ultra-high field 1H MRS.

 


Fig1 Transverse (a, c) and cut-away (b, d) views of the spectral-spatial saturation profiles (|Mxy|) of spatially selective excitation pulses designed by (a, b) using the LSQR method only, and (c, d) using the LSQR and OC methods in a combined manner.

 

Systematic investigation of influence factor on parallel transmit pulse performance


The parallel transmission technique helps to improve excitation uniformity and enables acceleration of related parallel transmit radiofrequency pulses in ultra-high field MRI. However, the overall performance of parallel transmission relates not only to the pulse design method and the specific arrangement of the transmit coil array, but is also influenced by several hardware and software imperfections. In this work, we systematically investigate the factors that could pose negative influence on the transmit pulse performance, including B1 mapping inaccuracy, B0 inhomogeneity, RF hardware and gradient hardware imperfection.

 


Fig 2 (a) Comparison of measured (blue) and theoretically designed (pink) k-space trajectory. (b) Measured (blue) and theoretically designed (pink) RF pulse shapes compared in two different voltage levels (upper row: 0~120V, lower row: 0~16V). (c) In vivo measured excitation profile (a vertical “MPI” figure shape) achieved by pulse designed by using B1 map acquired from AFI-corrected pre-conditioned TurboFLASH, with RF pulse delay calibration and consideration of k-space trajectory deviations.

 

Optimized transmit pulses for excellent whole-brain excitation homogeneity in high field MRI


Homogeneous whole-brain excitation is increasingly required in high field fMRI applications. To achieve homogeneous whole-brain coverage, we propose here an optimized 3D tailored RF (TRF) pulse for compensation of the severe RF field (B1) inhomogeneity, based on the recently developed parallel transmission technique. The RF pulse is designed with optimized stack-spiral trajectory tailored to fit into the ‘high-weight’ k-space area that is most responsible for the desired excitation pattern. The feature of this pulsing approach is that it produces optimized pulses that provide homogeneous excitation over the entire brain volume with shortened pulse duration and peak RF energy.

 

Fig 3 ) Cut-away (a & c, on the plane y=0) and transverse (b & d, on the oblique plane shown as the gray line in a) views of (a, b) the overall sensitivity map of an 8-channel array over the head part of virtual human data, and (c, d) the simulation result of excitation profile driven by the designed pulse sequence.

Education


11.2012 - now    Postdoctoral Fellow, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany
2.2008 - 9.2012  PhD in Biomedical Engineering, College of Biomedical Engineering &Instrument Science,                                      Zhejiang University, China

9.2009 - 3.2010  Visiting student, School of Information Technology & Electrical Engineering, The University                                  of Queensland, Australia
9.2006 - 1.2008  Master of Electromagnetic Fields & Micro-Wave Technology, College of Information Science                                  and Engineering, Zhejiang University, China
9.2000 - 6.2005  Bachelor of Biomedical Engineering, College of Biomedical Engineering &Instrument Science,                                Zhejiang University, China

 

Publications


Shao T, Xia L, Liu F, and Crozier S (May-2012), Advanced Three-dimensional Tailored RF Pulse Design in Volumetric Selective Parallel Excitation, Medical Imaging, IEEE Transaction on, 31(5), 997-1007.

 

Chi J, Liu F, Xia L, Shao T, and Crozier S (Feb-2011), An Improved Cylindrical FDTD Algorithm and Its Application to Field-Tissue Interaction Study in MRI, Magnetics, IEEE Transactions on , 47(2), 466-470.


Xia L, Shao T, Liu F (Dec-2011), A design method of 3D selective excitation sequence in MRI, CN Patent CN102283649A.

 

Xia L, Shao T, Liu F (Dec-2011), An MRI excitation pulse sequence generator, CN Patent CN102288929A.

 

Shao T, Zhang Y, Avdievich N, Glaser S, Henning A (June-2015), A parallel transmit spectral-spatial pulse design method for ultra-high field MRS combining LSQR and optimal control based optimization, 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Ontario, Canada


Shao T, Avdievich N, Chang YC, Hoffmann J, Scheffler K, Henning A (June-2015), Systematic investigation of influence factor on parallel transmit pulse performance at 9.4 Tesla, 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Ontario, Canada


Hoffmann J, Shajan G, Mirkes C, Shao T, Henning A, Pohmann R, Scheffler K (June-2015), Towards routine application of dynamic parallel transmission for whole-brain imaging at 9.4 Tesla, 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Ontario, Canada

 

Giapitzakis IA , Shao T, Avdievich N, Kreis R and Henning A  (May-2014): Optimisation of Asymmetric Adiabatic Pulses for Single Voxel Metabolite Cycled 1H-MRS in the Human Brain at 9.4 Tesla, Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2014), Milano, Italy.


Shao T, Xia L, Liu F, and Crozier S (May-2012), Optimized transmit pulses for excellent whole-brain excitation homogeneity in high field MRI, in Proceedings of the 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Victoria, Australia.

 

Xia L, Shao T, Zhu M, Shou G, Liu F, and Crozier S (May-2011),Accounting for B1 void using optimized transmit pulses in ultra high field MRI, 19th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2011), Montréal, Quebec, Canada.

Shao T, Zhu M, Xia L, Liu F (May-2011), Optimized slab selective parallel RF excitation at ultra high field, 5th International Conference on Bioinformatics and Biomedical Engineering (iCBBE 2011), Wuhan, China.

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Posters (4):

Shao T, Avdievich NI and Henning A (May-12-2016): 3D volumetric parallel excitation at 9.4T using the trajectory container concept, 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016), Singapore.
Shao T, Avdievich NI, Chang P, Hoffmann J, Scheffler K and Henning A (June-1-2015): Systematic investigation of influence factor on parallel transmit pulse performance at 9.4 Tesla, 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.
Hoffmann J, Shajan G, Mirkes C, Shao T, Henning A, Pohmann R and Scheffler K (June-1-2015): Towards routine application of dynamic parallel transmission for whole-brain imaging at 9.4 Tesla, 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.
Giapitzakis IA, Shao T, Avdievich N, Kreis R and Henning A (May-15-2014): Optimisation of Asymmetric Adiabatic Pulses for Single Voxel Metabolite Cycled 1H-MRS in the Human Brain at 9.4 Tesla, Joint Annual Meeting ISMRM-ESMRMB 2014, Milano, Italy.

Talks (4):

Shao T, Zhang Y, Avdievich N, Mirkes C, Scheffler K, Glaser S and Henning A (April-27-2017) Abstract Talk: Homogeneous high-flip-angle 3D localization by parallel transmission at 9.4T, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA(1122).
Giapitzakis I-A, Shao T, Avdievitsch N, Fichtner N, Merkle R, Kreis R and Henning A (April-27-2017) Abstract Talk: Metabolite cycled semi-LASER and STEAM at 9.4T: Comparison and in vivo results, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA(1061).
Shao T, Zhang Y, Avdievich NI, Glaser S and Henning A (October-2015) Abstract Talk: A parallel transmit spectral-spatial pulse design method for ultra-high field MRS combining LSQR and optimal control based optimization, 32nd Annual Scientific Meeting ESMRMB 2015, Edinburgh, UK, Magnetic Resonance Materials in Physics, Biology and Medicine, 28(1 Supplement) S404-S405.
Shao T, Zhang Y, Avdievich NI, Glaser S and Henning A (June-4-2015) Abstract Talk: A Parallel Transmit Spectral-Spatial Pulse Design Method for Ultra-High Field MRS Combining LSQR and Optimal Control Based Optimization, 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada(0918).

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Last updated: Tuesday, 18.11.2014