Contact

Sahar Nassirpour

Address: Max-Planck-Ring 11
72076 Tübingen
Room number: 1.A.01
Phone: +49 7071 601 939
Fax: +49 7071 601 702
E-Mail: Sahar.Nassirpour

 

Picture of Nassirpour, Sahar,

Sahar Nassirpour

Position: PhD Student  Unit: Henning Scheffler

- PhD student at Max Planck Institute for Biological Cybernetics

- Ultra High Field Department

- The purpose of my PhD thesis is to develop acquisition sequences, image reconstruction methods and quantification routines to enable whole brain metabolic imaging and quantification in the human brain by magnetic resonance spectroscopy at 9.4T.

Accelerated Multi-slice 1H FID-MRSI in the human brain at 9.4 T



Magnetic resonance spectroscopic imaging (MRSI) is a powerful technique for mapping metabolites over the entire brain volume that can provide sensitive markers of disease or injury and therefore plays an important role both in clinical diagnostics and in biomedical research. Compared to lower field strengths, MRSI at ultra-high fields has the advantage of higher signal to noise ratio as well as increased spectral resolution. This advantage enables the quantification of more metabolites in the brain. However, to be able to benefit from these advantages at ultra-high fields, there are many challenges that should be overcome. Some of these challenges include: shortened T2 and T2* relaxation times, severe chemical shift displacement artifacts, high spatial B1+ field inhomogeneity, long acquisition times, large B0 field inhomogeneity across the entire brain volume and processing of large multi-dimensional datasets in a robust and efficient manner. The purposes of this PhD thesis is to develop acquisition sequences, image reconstruction methods and quantification routines to overcome these challenges and enable whole brain metabolic imaging and quantification in the human brain by magnetic resonance spectroscopy at 9.4T.

 

Using the 1H FID MRSI sequence at 9.4T, we are able to reliably map up to 12 metabolites at a high resolution of 64x64. By using acceleration techniques and reducing the scan time, metabolite maps of the entire brain can be acquired in a reasonable scan time.

 

High resolution maps of 12 metabolites

 

Education:

06.2014 - Present:

Max Planck Institut für Biologishe Kybernetik, Tübingen

PhD Candidate

High-field Magnetic-Resonance Group

Graduate School of Neural and Behavioural Science

 

09.2009 - 12.2013:

Stanford University, Stanford, California

M.Sc. in Image System Engineering

Electrical Engineering Department

 

09.2004 - 06.2009:

Sharif University of Technology, Tehran, Iran

B.Sc. in Electrical Engineering

Electrical Engineering Department

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Show abstracts

Articles (6):

Chang P, Nassirpour S, Eschelbach M, Scheffler K and Henning A (August-2018) Constrained optimization for position calibration of an NMR field camera Magnetic Resonance Imaging 80(1) 380-390.
Chang P, Nassirpour S, Avdievich N and Henning A (August-2018) Non-water-suppressed 1H FID-MRSI at 3T and 9.4T Magnetic Resonance in Medicine 80(2) 442-451.
Nassirpour S, Chang P, Avdievitch N and Henning A (April-2018) Compressed sensing for high‐resolution nonlipid suppressed 1H FID MRSI of the human brain at 9.4T Magnetic Resonance in Medicine Epub ahead.
Nassirpour S, Chang P and Henning A (March-2018) High and ultra-high resolution metabolite mapping of the human brain using 1H FID MRSI at 9.4T NeuroImage 168 211-221.
Nassirpour S, Chang P, Fillmer A and Henning A (February-2018) A comparison of optimization algorithms for localized in vivo B0 shimming Magnetic Resonance in Medicine 79(2) 1145–1156.
Chang P, Nassirpour S and Henning A (January-2018) Modeling real shim fields for very high degree (and order) B0 shimming of the human brain at 9.4 T Magnetic Resonance in Medicine 79(1) 529–540.

Posters (22):

Aghaeifar A, Chang P, Nassirpour S, Eschelbach M, Henning A and Scheffler K (June-19-2018): A true comparison of B0 shimming with a very high order spherical harmonic based setup and a multi-coil shim array, Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.
Chang P, Nassirpour S and Henning A (June-19-2018): Measuring Eddy Currents Induced by Switching Gradient/Shim Currents, Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.
Nassirpour S, Chang P and Henning A (June-19-2018): Over-discretized SENSE reconstruction and B0 correction for accelerated non-lipid suppressed 1H FID MRSI of the human brain at 9.4T, Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.
Nassirpour S, Chang P, Avdievitch N and Henning A (June-19-2018): SNR Requirements for Successful Application of Compressed Sensing Acceleration to Non-lipid suppressed 1H MRSI at Ultra-High Fields, Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.
Chang P, Nassirpour S and Henning A (June-18-2018): Highly Accelerated (R=14) Water Reference Acquisition for High Resolution 1H MRSI using Compressed Sensing, Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.
Nassirpour S, Chang P and Henning A (June-18-2018): MultiNet PyGRAPPA: A Novel Method for Highly Accelerated Metabolite Mapping, Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.
Wright AM, Nassirpour S, Chang P and Henning A (June-18-2018): Toward Absolute Quantification Using External Reference Standards at 3T and 9.4T, Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.
Nassirpour S (January-2018): Pushing the limits of MR spectroscopic imaging: benefits and limitations of ultra-high field strengths for metabolite mapping of the human brain, 12th ESMI Winter Conference "hot TOPIics in IMaging": Imaging Metabolism (TOPIM 2018), Les Houches, France.
Chang P, Nassirpour S and Henning A (October-21-2017): Compressed sensing for 1H MRSI in the human brain at 9.4T, 34th Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2017), Barcelona, Spain, Magnetic Resonance Materials in Physics, Biology and Medicine, 30(Supplement 1) S485-S486.
Chang P, Nassirpour S and Henning A (October-21-2017): Low SAR lipid suppression for MRSI at ultra-high fields, 34th Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2017), Barcelona, Spain, Magnetic Resonance Materials in Physics, Biology and Medicine, 30(Supplement 1) S471.
Nassirpour S, Chang P and Henning A (October-21-2017): The necessity of parametrizing macromolecules for accurate quantification of ultra-short TE and TR 1H FID MRSI data at 9.4T, 34th Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2017), Barcelona, Spain, Magnetic Resonance Materials in Physics, Biology and Medicine, 30(Supplement 1) S473-S474.
Nassirpour S, Chang P and Henning A (April-27-2017): Comparison of different acceleration methods for high-resolution metabolite mapping using 1H FID MRSI at 9.4T, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Chang P, Nassirpour S and Henning A (April-26-2017): Decoupling Controller Design for Real-time Feedback of B0 Shim Systems, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Chang P, Nassirpour S and Henning A (April-26-2017): Dynamic B0 Shim Controller for Digital Pre-emphasis with Sub-millisecond Update Rate, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Chang P, Nassirpour S and Henning A (April-26-2017): Flexible General-Purpose Embedded System for Real-time Feedback and Dynamic B0 Shimming, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Chang P, Nassirpour S and Henning A (April-25-2017): Limitations of NMR Field Cameras for B0 Field Monitoring, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Chang YC, Nassirpour S, Fillmer A and Henning A (May-10-2016): Correcting Geometric Distortion in B0 Mapping, 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016), Singapore.
Chang YC, Nassirpour S and Henning A (May-10-2016): Very high order B0 Shimming of the human brain at 9.4 T considering Real B0 Shim Fields, 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016), Singapore.
Chang P, Nassirpour S and Henning A (March-2016): Very High‐order B0 Shimming for Single‐Shot EPI at 9.4 T in the Human Brain, ISMRM Workshop on Ultra High Field MRI: Technological Advances & Clinical Applications, Heidelberg, Germany.
Nassirpour S, Kirchner T, Giapitzakis IA and Henning A (June-4-2015): Accelerated Multi-slice 1H FID-MRSI in the human brain at 9.4 T, 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.
Giapitzakis IA, Nassirpour S, Avdievich N, Kreis R and Henning A (June-4-2015): Metabolite cycled single voxel 1H spectroscopy at 9.4T, 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.
Giapitzakis IA, Nassirpour S, Kreis R, Avdievich NI and Henning A (March-19-2015): Metabolite cycled proton magnetic resonance spectroscopy at 9.4T, 10th Annual Meeting of the European Society for Molecular Imaging (EMIM 2015), Tübingen, Germany.

Talks (13):

Chang P, Nassirpour S, Aghaeifar A, Scheffler K and Henning A (June-20-2018) Abstract Talk: Dynamic B0 Shimming for Multi-Slice Metabolite Mapping at Ultra-High Field in the Human Brain: Very High Order Spherical Harmonics vs. Multi-Coil, Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France(0833).
Nassirpour S, Chang P and Henning A (June-19-2018) Abstract Talk: Whole Brain High Resolution Metabolite Mapping Using 1H FID MRSI with Slice-wise B0 Shim Updating at 9.4T, Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France(0619).
Chang P, Nassirpour S and Henning A (October-19-2017) Abstract Talk: ConsTru: an optimal B0 shimming solution, 34th Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2017), Barcelona, Spain, Magnetic Resonance Materials in Physics, Biology and Medicine, 30(Supplement 1) S683-S684.
Nassirpour S, Chang P and Henning A (October-19-2017) Abstract Talk: Over-discrete SENSE and B0 correction for accelerated 1H FID MRSI of the human brain at 9.4T, 34th Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2017), Barcelona, Spain, Magnetic Resonance Materials in Physics, Biology and Medicine, 30(Supplement 1) S112.
Chang P, Nassirpour S and Henning A (April-27-2017) Abstract Talk: Fast non-water suppressed metabolite cycled 1H FID MRSI at both 3T and 9.4T, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA(1250) 724.
Nassirpour S, Chang P and Henning A (April-27-2017) Abstract Talk: High resolution maps of individual macromolecule components in the human brain at 9.4T, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA(1059) 619.
Nassirpour S, Chang P and Henning A (April-27-2017) Abstract Talk: Pushing the limits of ultra-high field MRSI: benefits and limitations of 9.4T for metabolite mapping of the human brain, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA(1248) 723.
Nassirpour S, Chang P and Henning A (April-26-2017) Abstract Talk: Multi-slice metabolite mapping with Very-High Degree Dynamic B0 Shim Updating at 9.4T using Accelerated 1H FID MRSI, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA(0971) 571-572.
Nassirpour S (August-16-2016) Abstract Talk: Metabolite Mapping of the Human Brain Using 1H FID MRSI at 9.4T, ISMRM Workshop on MR Spectroscopy: From Current Best Practice to Latest Frontiers, Allensbach-Hegne, Germany.
Nassirpour S (August-15-2016) Abstract Talk: A Comparison of Optimization Algorithms for Localized In-Vivo Shimming, ISMRM Workshop on MR Spectroscopy: From Current Best Practice to Latest Frontiers, Allensbach-Hegne, Germany.
Nassirpour S, Chang YC, Fillmer A and Henning A (May-13-2016) Abstract Talk: A Comparison of Optimization Algorithms for Localized in-vivo B0 Shimming, 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016), Singapore(1142).
Giapitzakis IA, Nassirpour S, Avdievich NI, Kreis R and Henning A (October-2015) Abstract Talk: 1H single voxel spectroscopy at occipital lobe of human brain at 9.4 T, 32nd Annual Scientific Meeting ESMRMB 2015, Edinburgh, UK, Magnetic Resonance Materials in Physics, Biology and Medicine, 28(1 Supplement) S208-S209.
Giapitzakis IA, Nassirpour S and Henning A (October-2015) Abstract Talk: Short duration water suppresion using optimised flip angles (SODA) at ultra high fields, 32nd Annual Scientific Meeting ESMRMB 2015, Edinburgh, UK, Magnetic Resonance Materials in Physics, Biology and Medicine, 28(1 Supplement) S401-S402.

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Last updated: Monday, 22.05.2017