Contact

Paul Fehling

Address: Max-Planck-Ring 11
72076 Tübingen
Room number: 3.B.10
Phone: +49 7071 601 736
Fax: +49 7071 601 702
E-Mail: paul.fehling

 

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Paul Fehling

Position: PhD Student  Unit: Scheffler

to be completed

Ultralow Field Magnetic Resonance utilizing continuous Overhauser dynamic nuclear Poalrization

ODNP (Overhauser dynamic nuclear Polarization) is a hyperpolarization technique, which works best at magnetic fields in the mT-range. At those fields, the penetration depth of the excitation pulse, needed to induce the hyperpolarization, is high enough to irradiate a sufficient sample volume.
In combination with a SQUID-based ultralow field (ULF) System, this technique provides enough signal to perform three-dimensionally resolved magnetic resonance imaging (MRI) scans at static magnetic fields up to a few mT.
The low-cost setup is used to develop biocompatible free radicals, needed to perform in-vivo continuous ODNP measurements. The goal of the Project is to perform first in-vivo ULF-MRI scans, using continuous ODNP, so that the enhancement provided by the hyperpolarization technique is high enough to achieve signal to noise ratios, comparable to conventional MRI scanners operating at 1T.

10.2011-01.2016 B.Sc. in Physics, Eberhard Karls University, Tübingen

02.2016-04.2017 M.Sc. in Physics, Eberhard Karls University, Tübingen

since 06.2017 PhD student at Max Planck Institute for Biological Cybernetics and Eberhard Karls University Tübingen

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Articles (1):

Buckenmaier K, Rudolph M, Black C, Misztal T, Bommerich U, Fehling P, Koelle D, Kleiner R, Mayer HH, Scheffler K, Bernarding J and Plaumann M (October-2017) SQUID-based detection of ultra-low-field multinuclear NMR of substances hyperpolarized using signal amplification by reversible exchange Scientific Reports 7(13431) 1-9.

Talks (4):

Fehling P, Bernard R, Pohmann R, Rudolph M, Kölle D, Kleiner R, Scheffler K and Buckenmaier K (June-20-2018) Abstract Talk: Ex vivo continuous Overhauser nuclear dynamic polarization in a SQUID-based ultralow field magnetic resonance imaging system, Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France(0949).
Buckenmaier K, Rudolph M, Fehling P, Back C, Bernarding J, Koelle D, Kleiner R, Scheffler K and Plaumann M (March-22-2018) Abstract Talk: SQUID based magnetic resonance imaging for the investigation of in situ and in vivo hyperpolarization techniques, 13th Annual Meeting of the European Society for Molecular Imaging (EMIM 2018), San Sebastián, Spain(PS-13-2).
Fehling P, Bernard R, Pohmann R, Rudolph M, Koelle D, Kleiner R, Scheffler K and Buckenmaier K (March-14-2018) Abstract Talk: Ex vivo continuous Overhauser nuclear dynamic polarization in a SQUID-based ultralow-field magnetic resonance imaging system, 82. Jahrestagung der Deutschen Physikalischen Gesellschaft und DPG-Frühjahrstagung, Berlin, Germany(TT 49.4).
Rudolph M, Misztal T, Antkowiak P, Meyer H, Kleiner R, Koelle D, Scheffler K and Buckenmaier K (March-9-2016) Abstract Talk: Ultra low field magnetic resonance imaging for the investigation of hyperpolarized contrast agents, 80. Jahrestagung der Deutschen Physikalischen Gesellschaft und DPG-Frühjahrstagung, Regensburg, Germany(TT 51.4).

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Last updated: Monday, 22.05.2017