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Prof. Dr. Nikos Logothetis

Address: Spemannstr. 38
72076 Tübingen
Room number: 121
Phone: +49 7071 601 651
Fax: +49 7071 601 652
E-Mail: nikos.logothetis

 

Picture of Logothetis, Nikos, Prof. Dr.

Nikos Logothetis

Position: Director  Unit: Logothetis

Research in this laboratory concentrates on the neural mechanisms of perception and object recognition. Although our basic research revolves around vision, a number of independent collaborators are also investigating the relationship between neural activity and perception using other sensory modalities. I firmly believe that such scientific questions require a multimodal methodological approach that integrates information obtained from single units with that derived from mass action potentials as well as from a number of activity-related, surrogate signals such as those monitored during noninvasive experiments. Parallel to our ongoing research, therefore, we are also working to develop methodologies that will permit us to study neural networks in the context of behavioral paradigms. We have already designed and implemented two high-field magnetic resonance imaging systems for functional, anatomical and spectroscopic imaging. The systems are endowed with all the necessary hard- and software to conduct simultaneous imaging and recordings, and they are being used to study the function, connectivity, and neurochemistry of the non-human primate brain. Furthermore, while continuing to exploit traditional neuroimaging in our experiments, we are also investigating the relationship of neural activity to the MR-measurable hemodynamic responses and experimenting with methods that do not rely on hemodynamic responses at all. In the context of the last-named project, a group of synthetic and coordination chemists in my laboratory are attempting to synthesize and evaluate MR-detectable smart probes that change magnetic properties as a function of the concentration of ions and molecules involved in neural signaling. Smart contrast agents, if designed and tested appropriately, promise to revolutionize invasive neuroimaging and would represent a quantum leap forward in signal-to-noise ratio, spatial detail and specificity, while affording unprecedented temporal resolution.
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Nikos K. Logothetis is director of the department “Physiology of Cognitive Processes” at the Max Planck Institute for Biological Cybernetics (MPIK), in Tübingen, Germany. He received a B.S. in mathematics from the University of Athens, a B.S. in biology from the University of Thessaloniki, and his Ph.D. in human neurobiology from the Ludwig-Maximilians University in Munich. In 1985 he moved to the Brain and Cognitive Sciences Department of M.I.T., where he initially worked as a postdoctoral fellow and later as Research Scientist. In 1990 he joined the faculty of the Division of Neuroscience at the Baylor College of Medicine. Seven years later he moved to the Max Planck Institute for Biological Cybernetics to continue his work on the physiological mechanisms underlying visual perception and object recognition.

In addition to visual cognition, his work at MPIC includes auditory perception and multisensory integration, as well as studies of plasticity and neuromodulation. Parallel to this ongoing research, a number of methods have been developed that permit the study of neural networks in the context of behavioral paradigms. Two high-field magnetic resonance imaging systems were designed and implemented for functional, anatomical and spectroscopic imaging. They permit simultaneous imaging and intracortical recordings and are being used to study the function, connectivity, and neurochemistry of the non-human primate brain, as well as the relationship of neural activity to the MR-measurable hemodynamic responses. Last but not least a group of synthetic and coordination chemists at MPIC are attempting to synthesize and evaluate MR-detectable smart probes that change magnetic properties as a function of the concentration of ions and molecules involved in neural signaling.

Since 1992 Nikos K. Logothetis has been Adjunct Professor of Neurobiology at the Salk Institute in San Diego, since 1995 Adjunct Professor of Ophthalmology at the Baylor College of Medicine, Houston, Associate of the Neurosciences Institute, San Diego, Senior Visiting Fellow in University College, London, Adjunct Professor in the Department of Cognitive and Neural Systems and of Cognitive and Neural Systems in the College of Arts and Sciences, both at the Boston University, Massachusetts, a  faculty member at the Victoria University of Manchester (VUM) in England, and Honorary Professor in the Department of Biology at the University of Tübingen.

Nikos K. Logothetis has been or continues to be a member of the Advisory Boards of McGovern Institute, M.I.T.; Brain and Cognitive Sciences, M.I.T., USA; POSIT Science Corporation, San Francisco, USA; IGPS, Freiburg, Germany; Centre of Excellence in Systems Neuroscience of the Academy of Finland, Helsinki, Finland; Brain Imaging Center, Frankfurt am Main, Germany; ICM-ADREC, Paris, France; Brain Center of the Hebrew University, Jerusalem, Israel, and in the Advisory Board of the Brain Research Center of the Weizmann Institute, Jerusalem, Israel.  He served as Receiving Editor for the European Journal of Neuroscience (EJN), Associate Editor for Trends in Cognitive Sciences (TICS), Neuron, Current Biology, Current Opinion Neurobiology, and is a regular reviewer for Nature, Nature Neuroscience, J Neuroscience, PNAS, Cerebral Cortex, Cerebral Blood Flow and Metabolism, Journal of Neurophysiology, Experimental Brain Research, and Vision Research. He is a member of the Society for Neuroscience, European Neuroscience Association, American Association for the Advancement of Science, Association for Research in Vision and Ophthalmology, New York Academy of Sciences, Society for Industrial and Applied Mathematics, American Mathematical Society, International Neuropsychological Society, and Mathematical Association of America.

Nikos K. Logothetis is member of the German Academy of Natural Scientists Leopoldina, of the Rodin Remediation Academy, Honorary Member of the American Academy of Arts and Sciences, and a foreign associate of the National Academy of Sciences of the United States. He is recipient of the DeBakey Award for Excellence in Science, the Golden Brain Award of the Minerva Foundation, the 2003 Louis-Jeantet Prize of Medicine, the 2004 Zülch-Price for Neuroscience, the 2007 IPSEN Prize for Neuronal Plasticity, and the 2008 Alden Spencer Award of Columbia University, New York.

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Articles (333):

Bartels A, Zeki S and Logothetis NK (March-2008) Natural vision reveals regional specialization to local motion and to contrast-invariant, global flow in the human brain. Cerebral Cortex 18(3) 705-717.
Montemurro MA, Rasch MJ, Murayama Y, Logothetis NK and Panzeri S (March-2008) Phase-of-Firing Coding of Natural Visual Stimuli in Primary Visual Cortex Current Biology 18(5) 375-380.
Wang Z, Maier A, Logothetis NK and Liang H (March-2008) Single-Trial Classification of Bistable Perception by Integrating Empirical Mode Decomposition, Clustering, and Support Vector Machine EURASIP Journal on Advances in Signal Processing 2008(592742) 1-8.
Wang Z, Maier A, Logothetis NK and Liang H (March-2008) Single-Trial Decoding of Bistable Perception Based on Sparse Nonnegative Tensor Decomposition Computational Intelligence and Neuroscience 2008(642387) 1-10.
Zappe A-C, Pfeuffer J, Merkle H, Logothetis NK and Goense JBM (March-2008) The effect of labeling parameters on perfusion-based fMRI in nonhuman primates Journal of Cerebral Blood Flow and Metabolism 28(3) 640-652.
Mishra A, Fousková P, Angelovski G, Balogh E, Mishra AK, Logothetis NK and Tóth É (February-2008) Facile Synthesis and Relaxation Properties of Novel Bispolyazamacrocyclic Gd3+ Complexes: An Attempt towards Calcium-Sensitive MRI Contrast Agents Inorganic Chemistry 47(4) 1370-1381.
Goense JBM, Ku S-P, Merkle H, Tolias AS and Logothetis NK (February-2008) fMRI of the temporal lobe of the awake monkey at 7 T NeuroImage 39(3) 1081-1093.
Nielsen KJ, Logothetis NK and Rainer G (February-2008) Object features used by humans and monkeys to identify rotated shapes Journal of Vision 8(2:9) 1-15.
Dhingra K, Fousková P, Angelovski G, Maier ME, Logothetis NK and Tóth É (January-2008) Towards extracellular Ca2+ sensing by MRI: synthesis and calcium-dependent 1H and 17O relaxation studies of two novel bismacrocyclic Gd3+ complexes. Journal of Biological Inorganic Chemistry 13(1) 35-46.
Tolias AS, Ecker AS, Siapas AG, Hoenselaar A, Keliris GA and Logothetis NK (December-2007) Recording Chronically from the same Neurons in Awake, Behaving Primates Journal of Neurophysiology 98(6) 3780-3790.
Mamedov I, Mishra A, Angelovski G, Mayer HA, Pålsson L-O, Parker D and Logothetis NK (December-2007) Synthesis and Characterization of Lanthanide Complexes of DO3A-Alkylphosphonates Dalton Transactions 36(45) 5260-5267.
Zhang X, Rauch A, Lee H, Xiao H, Rainer G and Logothetis NK (November-2007) Capillary hydrophilic interaction chromatography/mass spectrometry for simultaneous determination of multiple neurotransmitters in primate cerebral cortex. Rapid Communications in Mass Spectrometry 21(22) 3621-3628.
Mangia S, Tkac I, Logothetis NK, Gruetter R, Van de Moortele P-F and Ugurbil K (November-2007) Dynamics of lactate concentration and blood oxygen level-dependent effect in the human visual cortex during repeated identical stimuli Journal of Neuroscience Research 85(15) 3340–3346.
Lippert M, Logothetis NK and Kayser C (October-2007) Improvement of visual contrast detection by a simultaneous sound Brain Research 1173 102-109.
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Yacoub E, Shmuel A, Logothetis NK and Ugurbil K (October-2007) Robust detection of ocular dominance columns in humans using Hahn Spin Echo BOLD functional MRI at 7 Tesla NeuroImage 37(4) 1161–1177.
Logothetis NK (October-2007) The ins and outs of fMRI signals Nature Neuroscience 10(10) 1230-1232.
Kayser C and Logothetis NK (September-2007) Do early sensory cortices integrate cross-modal information? Brain Structure and Function 212(2) 121-132.
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Logothetis NK, Kayser C and Oeltermann A (September-2007) In Vivo Measurement of Cortical Impedance Spectrum in Monkeys: Implications for Signal Propagation Neuron 55(5) 809-823.
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Kayser C, Petkov CI and Logothetis NK (September-2007) Tuning to sound frequency in auditory field potentials Journal of Neurophysiology 98(3) 1806-1809.
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Oeltermann A, Ku S-P and Logothetis NK (July-2007) A novel functional magnetic resonance imaging compatible search-coil eye-tracking system Magnetic Resonance Imaging 25(6) 913-922.
Sultan F, Augath M and Logothetis NK (July-2007) BOLD sensitivity to cortical activation induced by microstimulation: comparison to visual stimulation Magnetic Resonance Imaging 25(6) 754-759.
Pfeuffer J, Shmuel A, Keliris GA, Steudel T, Merkle H and Logothetis NK (July-2007) Functional MR imaging in the awake monkey: effects of motion on dynamic off-resonance and processing strategies Magnetic Resonance Imaging 25(6) 869-882.
Zappe A-C, Reichold J, Burger C, Weber B, Buck A, Pfeuffer J and Logothetis NK (July-2007) Quantification of Cerebral Blood Flow in Nonhuman Primates Using Arterial Spin Labeling and a Two-Compartment Model Magnetic Resonance Imaging 25(6) 775-783.
Keliris GA, Shmuel A, Ku S-P, Pfeuffer J, Oeltermann A, Steudel T and Logothetis NK (July-2007) Robust Controlled Functional MRI in Alert Monkeys at High Magnetic Field: Effects of Jaw and Body Movements NeuroImage 36(3) 550-570.
Oeltermann A, Augath MA and Logothetis NK (July-2007) Simultaneous recording of neuronal signals and functional NMR imaging Magnetic Resonance Imaging 25(6) 760-774.
Hayashi R, Nishida S, Tolias A and Logothetis NK (June-2007) A method for generating a “purely first-order” dichoptic motion stimulus Journal of Vision 7(8:7) 1-10.
Hoffman KL, Gothard KM, Schmid MC and Logothetis NK (May-2007) Facial-Expression and Gaze-Selective Responses in the Monkey Amygdala Current Biology 17(9) 766-772.
Dahl CD, Logothetis NK and Hoffman KL (May-2007) Individuation and holistic processing of faces in Rhesus monkeys Proceedings of the Royal Society of London B 274(1622) 2069-2076.
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Wang Z, Maier A, Leopold DA, Logothetis NK and Liang H (April-2007) Single-trial evoked potential estimation using wavelets Computers in Biology and Medicine 37(4) 463–473.
Shmuel A, Yacoub E, Chaimow D, Logothetis NK and Ugurbil K (April-2007) Spatio-temporal point-spread function of fMRI signal in human gray matter at 7 Tesla NeuroImage 35(2) 539-552.
Maier A, Logothetis NK and Leopold DA (March-2007) Context-dependent perceptual modulation of single neurons in primate visual cortex Proceedings of the National Academy of Sciences of the United States of America 104(13) 5620-5625.
Kayser C, Petkov CI, Augath M and Logothetis NK (February-2007) Functional imaging reveals visual modulation of specific fields in auditory cortex Journal of Neuroscience 27(8) 1824-1835.
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Silver MA and Logothetis NK (February-2007) Temporal frequency and contrast tagging bias the type of competition in interocular switch rivalry Vision Research 47(4) 532-543.
Ghazanfar AA, Turesson HK, Maier JX, Dinther RV, Patterson RD and Logothetis NK (February-2007) Vocal-Tract Resonances as Indexical Cues in Rhesus Monkeys Current Biology 17(5) 425-430.
Smirnakis SM, Schmid MC, Weber B, Tolias AS, Augath M and Logothetis NK (January-2007) Spatial specificity of BOLD versus cerebral blood volume fMRI for mapping cortical organization Journal of Cerebral Blood Flow and Metabolism 27(6) 1248-1261.
Wilke M, Logothetis NK and Leopold DA (November-2006) Local field potential reflects perceptual suppression in monkey visual cortex Proceedings of the National Academy of Sciences of the United States of America 103(46) 17507-17512.
Juchem C, Mueller-Bierl B, Schick F, Logothetis NK and Pfeuffer J (September-2006) Combined passive and active shimming for in vivo MR spectroscopy at high magnetic fields Journal of Magnetic Resonance 183(2) 278-289.
Nielsen K, Logothetis NK and Rainer G (September-2006) Dissociation Between Local Field Potentials and Spiking Activity in Macaque Inferior Temporal Cortex Reveals Diagnosticity-Based Encoding of Complex Objects Journal of Neuroscience 26(38) 9639-9645.
Kayser C and Logothetis NK (August-2006) Vision: Stimulating Your Attention Current Biology 16(15) R581-R583.
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Petkov C, Kayser C, Augath M and Logothetis N (July-2006) Functional Imaging Reveals Numerous Fields in the Monkey Auditory Cortex PLoS Biology 4(7) 1213-1226.
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Mishra A, Pfeuffer J, Mishra R, Engelmann J, Mishra A, Ugurbil K and Logothetis NK (April-2006) A New Class of Gd-Based DO3A-Ethylamine-Derived Targeted Contrast Agents for MR and Optical Imaging Bioconjugate Chemistry 17(3) 773-780.
Tehovnik EJ, Tolias AS, Sultan F, Slocum WM and Logothetis NK (April-2006) Direct and Indirect Activation of Cortical Neurons by Electrical Microstimulation Journal of Neurophysiology 96(2) 512-521.
Nielsen KJ, Logothetis NK and Rainer G (April-2006) Discrimination Strategies of Humans and Rhesus Monkeys for Complex Visual Displays Current Biology 16(8) 814-820.
Gretton A, Belitski A, Murayama Y, Schölkopf B and Logothetis NK (April-2006) The Effect of Artifacts on Dependence Measurement in fMRI Magnetic Resonance Imaging 24(4) 401-409.
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Kourtzi Z, Augath M, Logothetis NK, Movshon A and Kiorpes L (March-2006) Development of visually evoked cortical activity in infant macaque monkeys studied longitudinally with fMRI Magnetic Resonance Imaging 24(4) 359-366.
Kayser C, Nielsen KJ and Logothetis NK (March-2006) Fixations in natural scenes: interaction of image structure and image content Vision Research 46(16) 2535-2545.
Goense JBM and Logothetis NK (March-2006) Laminar specificity in monkey V1 using high-resolution SE-fMRI. Magnetic Resonance Imaging 24(4) 381-392.
Shmuel A, Augath M, Oeltermann A and Logothetis NK (March-2006) Negative functional MRI response correlates with decreases in neuronal activity in monkey visual area V1 Nature Neuroscience 9(4) 569-577.
Schmid MC, Oeltermann A, Juchem C, Smirnakis SM and Logothetis NK (March-2006) Simultaneous EEG and fMRI in the macaque monkey at 4.7 Tesla Magnetic Resonance Imaging 24(4) 335-342.
Murayama Y, Weber B, Kadharbatcha SS, Augath M and Logothetis NK (March-2006) Tracing neural circuits in vivo with Mn-enhanced MRI Magnetic Resonance Imaging 24(4) 349-358.
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Last updated: Monday, 22.05.2017