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Prof. Dr. Nikos Logothetis

Address: Spemannstr. 38
72076 Tübingen
Room number: 121
Phone: +49 7071 601 651
Fax: +49 7071 601 652
E-Mail: nikos.logothetis

 

Picture of Logothetis, Nikos, Prof. Dr.

Nikos Logothetis

Position: Director  Unit: Logothetis

Research in this laboratory concentrates on the neural mechanisms of perception and object recognition. Although our basic research revolves around vision, a number of independent collaborators are also investigating the relationship between neural activity and perception using other sensory modalities. I firmly believe that such scientific questions require a multimodal methodological approach that integrates information obtained from single units with that derived from mass action potentials as well as from a number of activity-related, surrogate signals such as those monitored during noninvasive experiments. Parallel to our ongoing research, therefore, we are also working to develop methodologies that will permit us to study neural networks in the context of behavioral paradigms. We have already designed and implemented two high-field magnetic resonance imaging systems for functional, anatomical and spectroscopic imaging. The systems are endowed with all the necessary hard- and software to conduct simultaneous imaging and recordings, and they are being used to study the function, connectivity, and neurochemistry of the non-human primate brain. Furthermore, while continuing to exploit traditional neuroimaging in our experiments, we are also investigating the relationship of neural activity to the MR-measurable hemodynamic responses and experimenting with methods that do not rely on hemodynamic responses at all. In the context of the last-named project, a group of synthetic and coordination chemists in my laboratory are attempting to synthesize and evaluate MR-detectable smart probes that change magnetic properties as a function of the concentration of ions and molecules involved in neural signaling. Smart contrast agents, if designed and tested appropriately, promise to revolutionize invasive neuroimaging and would represent a quantum leap forward in signal-to-noise ratio, spatial detail and specificity, while affording unprecedented temporal resolution.
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Nikos K. Logothetis is director of the department “Physiology of Cognitive Processes” at the Max Planck Institute for Biological Cybernetics (MPIK), in Tübingen, Germany. He received a B.S. in mathematics from the University of Athens, a B.S. in biology from the University of Thessaloniki, and his Ph.D. in human neurobiology from the Ludwig-Maximilians University in Munich. In 1985 he moved to the Brain and Cognitive Sciences Department of M.I.T., where he initially worked as a postdoctoral fellow and later as Research Scientist. In 1990 he joined the faculty of the Division of Neuroscience at the Baylor College of Medicine. Seven years later he moved to the Max Planck Institute for Biological Cybernetics to continue his work on the physiological mechanisms underlying visual perception and object recognition.

In addition to visual cognition, his work at MPIC includes auditory perception and multisensory integration, as well as studies of plasticity and neuromodulation. Parallel to this ongoing research, a number of methods have been developed that permit the study of neural networks in the context of behavioral paradigms. Two high-field magnetic resonance imaging systems were designed and implemented for functional, anatomical and spectroscopic imaging. They permit simultaneous imaging and intracortical recordings and are being used to study the function, connectivity, and neurochemistry of the non-human primate brain, as well as the relationship of neural activity to the MR-measurable hemodynamic responses. Last but not least a group of synthetic and coordination chemists at MPIC are attempting to synthesize and evaluate MR-detectable smart probes that change magnetic properties as a function of the concentration of ions and molecules involved in neural signaling.

Since 1992 Nikos K. Logothetis has been Adjunct Professor of Neurobiology at the Salk Institute in San Diego, since 1995 Adjunct Professor of Ophthalmology at the Baylor College of Medicine, Houston, Associate of the Neurosciences Institute, San Diego, Senior Visiting Fellow in University College, London, Adjunct Professor in the Department of Cognitive and Neural Systems and of Cognitive and Neural Systems in the College of Arts and Sciences, both at the Boston University, Massachusetts, a  faculty member at the Victoria University of Manchester (VUM) in England, and Honorary Professor in the Department of Biology at the University of Tübingen.

Nikos K. Logothetis has been or continues to be a member of the Advisory Boards of McGovern Institute, M.I.T.; Brain and Cognitive Sciences, M.I.T., USA; POSIT Science Corporation, San Francisco, USA; IGPS, Freiburg, Germany; Centre of Excellence in Systems Neuroscience of the Academy of Finland, Helsinki, Finland; Brain Imaging Center, Frankfurt am Main, Germany; ICM-ADREC, Paris, France; Brain Center of the Hebrew University, Jerusalem, Israel, and in the Advisory Board of the Brain Research Center of the Weizmann Institute, Jerusalem, Israel.  He served as Receiving Editor for the European Journal of Neuroscience (EJN), Associate Editor for Trends in Cognitive Sciences (TICS), Neuron, Current Biology, Current Opinion Neurobiology, and is a regular reviewer for Nature, Nature Neuroscience, J Neuroscience, PNAS, Cerebral Cortex, Cerebral Blood Flow and Metabolism, Journal of Neurophysiology, Experimental Brain Research, and Vision Research. He is a member of the Society for Neuroscience, European Neuroscience Association, American Association for the Advancement of Science, Association for Research in Vision and Ophthalmology, New York Academy of Sciences, Society for Industrial and Applied Mathematics, American Mathematical Society, International Neuropsychological Society, and Mathematical Association of America.

Nikos K. Logothetis is member of the German Academy of Natural Scientists Leopoldina, of the Rodin Remediation Academy, Honorary Member of the American Academy of Arts and Sciences, and a foreign associate of the National Academy of Sciences of the United States. He is recipient of the DeBakey Award for Excellence in Science, the Golden Brain Award of the Minerva Foundation, the 2003 Louis-Jeantet Prize of Medicine, the 2004 Zülch-Price for Neuroscience, the 2007 IPSEN Prize for Neuronal Plasticity, and the 2008 Alden Spencer Award of Columbia University, New York.

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Posters (536):

Liebe S, Logothetis NK and Rainer G (August-2006): The effect of adaptation on signal and noise in the human visual system, 29th European Conference on Visual Perception, St. Petersburg, Perception, 35(ECVP Abstract Supplement) 88.
Sigala R, Koch A, Nielsen KJ, Logothetis NK and Rainer G (August-2006): Using 3-D human-monkey morphs to explore the boundaries of species dependent face-categories in humans, 29th European Conference on Visual Perception, St. Petersburg, Russia, Perception, 35(ECVP Abstract Supplement) 207-208.
Rauch A, Augath M, Oeltermann A, Rainer G and Logothetis NK (July-2006): Decoupling of BOLD and neuronal activity in the gamma range during recovery from lidocaine inactivation, 5th Forum of European Neuroscience (FENS 2006), Wien, Austria.
Zhang X, Rauch A, Logothetis NK and Rainer G (July-2006): Neurotransmitter analysis in the monkey prefrontal and visual cortex using direct sampling, 5th Forum of European Neuroscience (FENS 2006), Wien, Austria.
Weber B, Keller AL, Groso A, Stampanoni M and Logothetis NK (July-2006): Quantitative aspects of the microvascular system in macaque visual cortex, 5th Forum of European Neuroscience (FENS 2006), Wien, Austria.
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Moutoussis K, Maier A, Zeki S and Logothetis NK (June-2006): "Seeing" invisible motion: responses of area V5 neurons in the awake-behaving macaque, AREADNE 2006: Research in Encoding and Decoding of Neural Ensembles, Santorini, Greece.
Goense JBM and Logothetis NK (June-2006): FMRI of V1 microarchitecture in the macaque at 4.7T, AREADNE 2006: Research in Encoding and Decoding of Neural Ensembles, Santorini, Greece.
Kayser C, Petkov C and Logothetis NK (June-2006): Functional imaging of sensory integration in auditory cortex, 6th Congress of the Federation of European Psychophysiology Societies (FEPS 2006), Budapest, Hungary.
Dahl CD, Logothetis NK and Hoffman KL (June-2006): Holistic and subordinate-level face processing in monkeys, 6th Annual Meeting of the Vision Sciences Society (VSS 2006), Sarasota, FL, USA, Journal of Vision, 6(6) 432.
Sigala R, Liebe S, Nielsen K, Logothetis NK and Reiner G (June-2006): Inferior temporal cortex during real world vision, AREADNE 2006: Research in Encoding and Decoding of Neural Ensembles, Santorini, Greece.
Kayser C, Petkov C and Logothetis NK (June-2006): Integration of sensory information in auditory cortex, AREADNE 2006: Research in Encoding and Decoding of Neural Ensembles, Santorini, Greece.
Bartels A, Maugath , Moutoussis K, Zeki S and Logothetis N (June-2006): Natural movie stimuli allow mapping of retinotopy and tonotopy in anesthetized monkey cortex, AREADNE 2006: Research in Encoding and Decoding of Neural Ensembles, Santorini, Greece.
Keliris GA, Logothetis NK and Tolias A (June-2006): Perceptual Suppression in area V1 of the Macaque, AREADNE 2006: Research in Encoding and Decoding of Neural Ensembles, Santorini, Greece.
Panzeri S, Montemurro MA and Logothetis NK (June-2006): Population coding of natural video stimuli in macaque V1, AREADNE 2006: Research in Encoding and Decoding of Neural Ensembles, Santorini, Greece.
Berens P, Ecker AS, Hoenselaar A, Keliris GA, Siapas AG, Logothetis NK and Tolias AS (June-2006): Spikes are phase locked to the gamma-band of the local field potential oscillations in the primary visual cortex of the macaque, AREADNE 2006: Research in Encoding and Decoding of Neural Ensembles, Santorini, Greece.
Zappe A, Merkle H, Pfeuffer J and Logothetis NK (May-10-2006): Perfusion-based functional imaging in the monkey brain at 7T: investigations of CASL parameters, 14th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2006), Seattle, WA, USA.
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Goense JBM and Logothetis NK (May-9-2006): Laminar specificity of the SE-fMRI signal in monkey striate visual cortex, 14th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2006), Seattle, WA, USA.
Juchem C, Logothetis NK and Pfeuffer J (May-8-2006): A Simple Approach of Combined Passive and Active Shimming for In Vivo MR Spectroscopy at High Magnetic Field, 14th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2006), Seattle, WA, USA.
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Tolias AS, Ecker A, Keliris GA, Siapas TG, Smirnakis SM and Logothetis NK (March-2006): Structure of interneuronal correlations in the primary visual cortex of the rhesus macaque, Computational and Systems Neuroscience Meeting (COSYNE 2006), Salt Lake City, UT, USA.
Liebe S, Logothetis NK and Rainer G (March-2006): The Contribution of Color to Recognition Performance in the Non-Human Primate, 9th Tübingen Perception Conference (TWK 2006), Tübingen, Germany.
Weber B, Keller AL and Logothetis NK (November-2005): Area- and layer-specific vascular density in the macaque striate and extrastriate cortex, 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005), Washington, DC, USA.
Hoffman KL, Gothard KM and Logotethis NK (November-2005): BOLD-dependent responses to facial expression and gaze direction in the awake monkey, 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005), Washington, DC, USA.
Keliris GA, Smirnakis SM, Tolias AS and Logothetis NK (November-2005): Directional selectivity of human visual areas after adaptation to motion stimuli: an fMRI study, 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005), Washington, DC, USA.
Petkov CI, Kayser C, Augath M, Steudel T and Logothetis NK (November-2005): fMRI of Macaque Auditory Cortex in Awake and in Anesthetized Animals, 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005), Washington, DC, USA.
Goense J, Ku S-P, Tolias AS and Logothetis NK (November-2005): fMRI of the temporal lobe of the awake macaque at 7T, 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005), Washington, DC, USA.
Juchem C, Logothetis NK and Pfeuffer J (November-2005): In vivo 1H MR spectroscopy at 7T in the primary visual cortex of the macaque monkey, 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005), Washington, DC, USA.
Shmuel A, Deubelius A, Steudel T and Logothetis NK (November-2005): Increased activity in monkey V1 and V2 during fixation, 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005), Washington, DC, USA.
Kayser C, Petkov C, Augath M and Logothetis NK (November-2005): Integration of touch and sound in auditory cortex, 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005), Washington, DC, USA.
Gretton A, Belitski A, Murayama Y, Schölkopf B and Logothetis NK (November-2005): Kernel methods for dependence testing in LFP-MUA, 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005), Washington, DC, USA.
Wilke M, Logothetis NK and Leopold DA (November-2005): Local field potential modulation during generalized flash suppression in the monkey, 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005), Washington, DC, USA.
Maier J, Logothetis NK and Ghazanfar AA (November-2005): Looming versus receding signals in rhesus monkey auditory cortex, 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005), Washington, DC, USA.
Smirnakis SM, Schmid MC, Tolias AS, Augath M and Logothetis NK (November-2005): Macaque visual cortex organization probed by fMRI after area V1 lesions, 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005), Washington, DC, USA.
Bartels A, Augath M, Moutoussis K, Zeki S and Logothetis NK (November-2005): Movie presentation allows mapping of retinotopy, color, and face-related activity in the anesthetized monkey brain, 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005), Washington, DC, USA.
Deubelius A, Steudel T, Logotethis NK and Shmuel A (November-2005): Negative BOLD response in early visual areas of the alert monkey, 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005), Washington, DC, USA.
Maier AV, Logothetis NK and Leopold DA (November-2005): Percept-related fluctuations of MT local field potentials, 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005), Washington, DC, USA.
Moutoussis K, Maier A, Zeki S and Logothetis NK (November-2005): Seeing invisible motion: responses of area V5 neurons in the awake-behaving macaque, 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005), Washington, DC, USA.
Schmid MC, Oeltermann A, Juchem C, Merkle H, Smirnakis SM and Logothetis NK (November-2005): Simultaneous EEG and fMRI in the macaque monkey at 4.7 T, 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005), Washington, DC, USA.
Rauch A, Augath M, Oeltermann A, Rainer G and Logothetis NK (November-2005): The effect of lidocaine on neural activity and BOLD activity in monkey primary visual cortex, 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005), Washington, DC, USA.
Mamedov I, Pfeuffer J, Logothetis NK and Mayer HA (September-2005): Assessment of Bis-macrocyclic Compounds as Calcium-sensitive MR Contrast Agents, 4th Annual Meeting of the Society for Molecular Imaging (SMI 2005), Köln, Germany.
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Mamedov I, Pfeuffer J, Logotethis NK and Mayer HA (September-2005): Azamacrocyclic Ca2+ Sensitive Contrast Agents for MR Imaging, 4th Annual Meeting of the Society for Molecular Imaging (SMI 2005), Köln, Germany.
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Mishra A, Pfeuffer J, Albert K, Mishra AK and Logothetis NK (September-2005): Facile Synthesis of Gd-DO3A-EA Conjugated with DTPA: A Novel Calcium Dependent MR Contrast Agent, 4th Annual Meeting of the Society for Molecular Imaging (SMI 2005), Köln, Germany.
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Jordan KE, Brannon EM, Logothetis NK and Ghazanfar AA (September-2005): Monkeys match the number of voices they hear to the number of faces they see, Fifth Annual Meeting of the Vision Sciences Society (VSS 2005), Sarasota, FL, USA, Journal of Vision, 5(8) 887.
Mamedov I, Mishra A, Pfeuffer J and Logothetis NK (September-2005): Novel Azamacrocyclic Conjugates in the Development of “Smart” and Targeted Contrast Agents for MR Imaging, 4th Annual Meeting of the Society for Molecular Imaging (SMI 2005), Köln, Germany.
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Maier A, Wilke M, Logothetis NK and Leopold DA (September-2005): Perceptual and neuronal dynamics of binocular rivalry flash suppression, Fifth Annual Meeting of the Vision Sciences Society (VSS 2005), Sarasota, FL, USA, Journal of Vision, 5(8) 12.
Juchem C, Logothetis NK and Pfeuffer J (September-2005): Simple approach of combined passive and active shimming for in vivo MR spectroscopy of the brain, 22nd Annual Meeting of the ESMRMB 2005, Basel, Switzerland, Magnetic Resonance Materials in Physics, Biology and Medicine, 18(Supplement 1) S133.
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Wilke M, Logothetis NK and Leopold DA (September-2005): Temporal dynamics of generalized flash suppression in V4, Fifth Annual Meeting of the Vision Sciences Society (VSS 2005), Sarasota, FL, USA, Journal of Vision, 5(8) 13.
Deubelius A, Logothetis NK and Shmuel A (August-2005): Decreased detectability of targets in non-stimulated regions of the visual field, 28th European Conference on Visual Perception, A Coruña, Spain, Perception, 34(ECVP Abstract Supplement) 91.
Mamedov I, Pfeuffer J, Logothetis NK and Mayer HA (July-2005): Functionalized azamacrocyclic compounds as Ca2+ sensitive contrast agents for MR imaging, XXX. International Symposium on Macrocyclic Chemistry (ISMC 2005), Dresden, Germany.
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Mishra A, Pfeuffer J, Logothetis NK and Mishra AK (July-2005): Multipurpose gadolinium-based ligand DO3A-EA as precursor for conjugation with organic molecules to develop smart and targeted contrast agents for MR and optical imaging, XXX. International Symposium on Macrocyclic Chemistry (ISMC 2005), Dresden, Germany.
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Maier J, Logothetis NK and Ghazanfar A (June-2005): Multisensory processing of looming signals in primates, 6th International Multisensory Research Forum (IMRF 2005), Trento, Italy.
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Last updated: Tuesday, 18.11.2014