Prof. Dr. Nikos Logothetis

Address: Spemannstr. 38
72076 Tübingen
Room number: 121
Phone: +49 7071 601 651
Fax: +49 7071 601 652
E-Mail: nikos.logothetis


Picture of Logothetis, Nikos, Prof. Dr.

Nikos Logothetis

Position: Director  Unit: Logothetis

Research in this laboratory concentrates on the neural mechanisms of perception and object recognition. Although our basic research revolves around vision, a number of independent collaborators are also investigating the relationship between neural activity and perception using other sensory modalities. I firmly believe that such scientific questions require a multimodal methodological approach that integrates information obtained from single units with that derived from mass action potentials as well as from a number of activity-related, surrogate signals such as those monitored during noninvasive experiments. Parallel to our ongoing research, therefore, we are also working to develop methodologies that will permit us to study neural networks in the context of behavioral paradigms. We have already designed and implemented two high-field magnetic resonance imaging systems for functional, anatomical and spectroscopic imaging. The systems are endowed with all the necessary hard- and software to conduct simultaneous imaging and recordings, and they are being used to study the function, connectivity, and neurochemistry of the non-human primate brain. Furthermore, while continuing to exploit traditional neuroimaging in our experiments, we are also investigating the relationship of neural activity to the MR-measurable hemodynamic responses and experimenting with methods that do not rely on hemodynamic responses at all. In the context of the last-named project, a group of synthetic and coordination chemists in my laboratory are attempting to synthesize and evaluate MR-detectable smart probes that change magnetic properties as a function of the concentration of ions and molecules involved in neural signaling. Smart contrast agents, if designed and tested appropriately, promise to revolutionize invasive neuroimaging and would represent a quantum leap forward in signal-to-noise ratio, spatial detail and specificity, while affording unprecedented temporal resolution.
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Nikos K. Logothetis is director of the department “Physiology of Cognitive Processes” at the Max Planck Institute for Biological Cybernetics (MPIK), in Tübingen, Germany. He received a B.S. in mathematics from the University of Athens, a B.S. in biology from the University of Thessaloniki, and his Ph.D. in human neurobiology from the Ludwig-Maximilians University in Munich. In 1985 he moved to the Brain and Cognitive Sciences Department of M.I.T., where he initially worked as a postdoctoral fellow and later as Research Scientist. In 1990 he joined the faculty of the Division of Neuroscience at the Baylor College of Medicine. Seven years later he moved to the Max Planck Institute for Biological Cybernetics to continue his work on the physiological mechanisms underlying visual perception and object recognition.

In addition to visual cognition, his work at MPIC includes auditory perception and multisensory integration, as well as studies of plasticity and neuromodulation. Parallel to this ongoing research, a number of methods have been developed that permit the study of neural networks in the context of behavioral paradigms. Two high-field magnetic resonance imaging systems were designed and implemented for functional, anatomical and spectroscopic imaging. They permit simultaneous imaging and intracortical recordings and are being used to study the function, connectivity, and neurochemistry of the non-human primate brain, as well as the relationship of neural activity to the MR-measurable hemodynamic responses. Last but not least a group of synthetic and coordination chemists at MPIC are attempting to synthesize and evaluate MR-detectable smart probes that change magnetic properties as a function of the concentration of ions and molecules involved in neural signaling.

Since 1992 Nikos K. Logothetis has been Adjunct Professor of Neurobiology at the Salk Institute in San Diego, since 1995 Adjunct Professor of Ophthalmology at the Baylor College of Medicine, Houston, Associate of the Neurosciences Institute, San Diego, Senior Visiting Fellow in University College, London, Adjunct Professor in the Department of Cognitive and Neural Systems and of Cognitive and Neural Systems in the College of Arts and Sciences, both at the Boston University, Massachusetts, a  faculty member at the Victoria University of Manchester (VUM) in England, and Honorary Professor in the Department of Biology at the University of Tübingen.

Nikos K. Logothetis has been or continues to be a member of the Advisory Boards of McGovern Institute, M.I.T.; Brain and Cognitive Sciences, M.I.T., USA; POSIT Science Corporation, San Francisco, USA; IGPS, Freiburg, Germany; Centre of Excellence in Systems Neuroscience of the Academy of Finland, Helsinki, Finland; Brain Imaging Center, Frankfurt am Main, Germany; ICM-ADREC, Paris, France; Brain Center of the Hebrew University, Jerusalem, Israel, and in the Advisory Board of the Brain Research Center of the Weizmann Institute, Jerusalem, Israel.  He served as Receiving Editor for the European Journal of Neuroscience (EJN), Associate Editor for Trends in Cognitive Sciences (TICS), Neuron, Current Biology, Current Opinion Neurobiology, and is a regular reviewer for Nature, Nature Neuroscience, J Neuroscience, PNAS, Cerebral Cortex, Cerebral Blood Flow and Metabolism, Journal of Neurophysiology, Experimental Brain Research, and Vision Research. He is a member of the Society for Neuroscience, European Neuroscience Association, American Association for the Advancement of Science, Association for Research in Vision and Ophthalmology, New York Academy of Sciences, Society for Industrial and Applied Mathematics, American Mathematical Society, International Neuropsychological Society, and Mathematical Association of America.

Nikos K. Logothetis is member of the German Academy of Natural Scientists Leopoldina, of the Rodin Remediation Academy, Honorary Member of the American Academy of Arts and Sciences, and a foreign associate of the National Academy of Sciences of the United States. He is recipient of the DeBakey Award for Excellence in Science, the Golden Brain Award of the Minerva Foundation, the 2003 Louis-Jeantet Prize of Medicine, the 2004 Zülch-Price for Neuroscience, the 2007 IPSEN Prize for Neuronal Plasticity, and the 2008 Alden Spencer Award of Columbia University, New York.

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Articles (332):

Ortiz-Rios M, Azevedo FAC, Kuśmierek P, Balla DZ, Munk MH, Keliris GA, Logothetis NK and Rauschecker P (February-2017) Widespread and Opponent fMRI Signals Represent Sound Location in Macaque Auditory Cortex Neuron 93(4) 971–983.
Totah NK, Neves RM, Panzeri S, Logothetis NK and Eschenk O (February-2017) Monitoring large populations of locus coeruleus neurons reveals the non-global nature of the norepinephrine neuromodulatory system - . submitted
Takemura H, Pestilli F, Weiner KS, Keliris GA, Landi SM, Sliwa J, Ye FQ, Barnett MA, Leopold DA, Freiwald WA, Logothetis NK and Wandell BA (August-2016) Occipital white matter tracts in human and macaque - . submitted
Hindriks R, Arsiwalla XD, Panagiotaropoulos T, Besserve M, Verschure PF, Logothetis NK and Deco G (July-2016) Discrepancies between multi-electrode LFP and CSD phase-patterns: A forward modeling study Frontiers in Neural Circuits 10(51) 1-18.
Goense J, Bohraus Y and Logothetis NK (June-2016) fMRI at High Spatial Resolution: Implications for BOLD-Models Frontiers in Computational Neuroscience 10(66) 1-13.
Gündüz S, Savić T, Pohmann R, Logothetis NK, Scheffler K and Angelovski G (June-2016) Ratiometric Method for Rapid Monitoring of Biological Processes Using Bioresponsive MRI Contrast Agents ACS Sensors 1(5) 483–487.
Novitskaya Y, Sara SJ, Logothetis NK and Eschenko O (May-2016) Ripple-triggered stimulation of the locus coeruleus during post-learning sleep disrupts ripple/spindle coupling and impairs memory consolidation Learning & Memory 23(5) 238-248.
Klein C, Evrard HC, Shapcott KA, Haverkamp S, Logothetis NK and Schmid MC (April-2016) Cell-Targeted Optogenetics and Electrical Microstimulation Reveal the Primate Koniocellular Projection to Supra-granular Visual Cortex Neuron 90(1) 143–151.
Garello F, Vibhute S, Gündüz S, Logothetis NK, Terreno E and Angelovski G (April-2016) Innovative Design of Ca-Sensitive Paramagnetic Liposomes Results in an Unprecedented Increase in Longitudinal Relaxivity Biomacromolecules 17(4) 1303–1311.
Kaplan R, Adhikari MH, Hindriks R, Mantini D, Murayama Y, Logothetis NK and Deco G (March-2016) Hippocampal Sharp-Wave Ripples Influence Selective Activation of the Default Mode Network Current Biology 26(5) 686–691.
Hindriks R, Adhikari MH, Murayama Y, Ganzetti M, Mantini D, Logothetis NK and Deco G (February-2016) Can sliding-window correlations reveal dynamic functional connectivity in resting-state fMRI? NeuroImage 127 242–256.
Perrodin C, Kayser C, Abel TJ, Logothetis NK and Petkov CI (December-2015) Who is That? Brain Networks and Mechanisms for Identifying Individuals Trends in Cognitive Sciences 19(12) 783–796.
Ramirez-Villegas JF, Logothetis NK and Besserve M (November-2015) Diversity of sharp-wave–ripple LFP signatures reveals differentiated brain-wide dynamical events Proceedings of the National Academy of Sciences of the United States of America 112(46) E6379–E6387.
Regueiro-Figueroa M, Gündüz S, Patinec V, Logothetis NK, Esteban-Gómez D, Tripier R, Angelovski G and Platas-Iglesias C (November-2015) Gd3+-Based Magnetic Resonance Imaging Contrast Agent Responsive to Zn2+ Inorganic Chemistry 54(21) 10342–10350.
Azadbakht H, Parkes LM, Haroon HA, Augath M, Logothetis NK, de Crespigny E, D'Arceuil HE and Parker GJM (November-2015) Validation of High-Resolution Tractography Against In Vivo Tracing in the Macaque Visual Cortex Cerebral Cortex 25(11) 4299-4309.
Totah NK, Logothetis NK and Eschenko O (October-2015) Atomoxetine accelerates attentional set shifting without affecting learning rate in the rat Psychopharmacology 232(20) 3697-3707.
Safaai H, Neves R, Eschenko O, Logothetis NK and Panzeri S (October-2015) Modeling the effect of locus coeruleus firing on cortical state dynamics and single-trial sensory processing Proceedings of the National Academy of Sciences of the United States of America 112(41) 12834–12839.
Papanikolaou A, Keliris GA, Lee S, Logothetis NK and Smirnakis SM (October-2015) Nonlinear population receptive field changes in human area V5/MT + of healthy subjects with simulated visual field scotomas NeuroImage 120 176–190.
Zaidi AD, Munk MHJ, Schmidt A, Risueno-Segovia C, Bernard R, Fetz E, Logothetis NK, Bierbaumer N and Sitaram R (October-2015) Simultaneous epidural functional near-infrared spectroscopy and cortical electrophysiology as a tool for studying local neurovascular coupling in primates NeuroImage 120 394–399.
Moussaron A, Vibhute S, Bianchi A, Gündüz S, Kolb S, Sancey L, Motto-Ros V, Rizzitelli S, Crémillieux Y, Lux F, Logothetis NK, Tillement O and Angelovski G (October-2015) Ultrasmall Nanoplatforms as Calcium-Responsive Contrast Agents for Magnetic Resonance Imaging Small 11(37) 4900–4909.
Besserve M, Lowe SC, Logothetis NK, Schölkopf B and Panzeri S (September-2015) Shifts of Gamma Phase across Primary Visual Cortical Sites Reflect Dynamic Stimulus-Modulated Information Transfer PLoS Biology 13(9) 1-29.
Azevedo FAC, Ortiz-Rios M, Li Q, Logothetis NK and Keliris GA (July-2015) A Potential Role of Auditory Induced Modulations in Primary Visual Cortex Multisensory Research 28(3-4) 331-349.
Oukhatar F, Meudal H, Landon C, Logothetis NK, Platas-Iglesias C, Angelovski G and Toth E (July-2015) Macrocyclic Gd3+ Complexes with Pendant Crown Ethers Designed for Binding Zwitterionic Neurotransmitters Chemistry - A European Journal 21(31) 11226–11237.
Florin E, Watanabe M and Logothetis NK (June-2015) The role of sub-second neural events in spontaneous brain activity Current Opinion in Neurobiology 32 24–30.
Logothetis NK (April-2015) Neural-Event-Triggered fMRI of large-scale neural networks Current Opinion in Neurobiology 31 214–222.
Gündüz S, Power A, Maier ME, Logothetis NK and Angelovski G (March-2015) Synthesis and Characterization of a Biotinylated Multivalent Targeted Contrast Agent ChemPlusChem 80(3) 612–622.
Oukhatar F, Même S, Même W, Szeremeta F, Logothetis NK, Angelovski G and Toth E (February-2015) MRI sensing of neurotransmitters with a crown-ether appended Gd3+ complex ACS Chemical Neuroscience 6(2) 219–225.
Gündüz S, Nitta N, Vibhute SM, Shibata S, Maier ME, Logothetis NK, Aoki I and Angelovski G (January-2015) Dendrimeric Calcium-responsive MRI Contrast Agents with Slow in vivo Diffusion Chemical Communications 51(14) 2782-2785.
Petkov CI, Kikuchi Y, Milne AE, Mishkin M, Rauschecker JP and Logothetis NK (January-2015) Different forms of effective connectivity in primate frontotemporal pathways Nature Communications 6(6000) 1-12.
Perrodin C, Kayser C, Logothetis NK and Petkov CI (January-2015) Natural asynchronies in audiovisual communication signals regulate neuronal multisensory interactions in voice-sensitive cortex Proceedings of the National Academy of Sciences of the United States of America 112(1) 273–278.
Zaldivar D, Rauch A, Whittingstall K, Logothetis NK and Goense J (December-2014) Dopamine-Induced Dissociation of BOLD and Neural Activity in Macaque Visual Cortex Current Biology 24(23) 2805–2811.
Liewald D, Miller R, Logothetis NK, Wagner H-J and Schüz A (October-2014) Distribution of axon diameters in cortical white matter: an electron-microscopic study on three human brains and a macaque Biological Cybernetics 108(5) 541-557.
Barbieri F, Mazzoni A, Logothetis NK, Panzeri S and Brunel N (October-2014) Stimulus Dependence of Local Field Potential Spectra: Experiment versus Theory Journal of Neuroscience 34(44) 14589-14605.
Bahmani H, Murayama Y, Logothetis NK and Keliris GA (September-2014) Binocular Flash Suppression in the Primary Visual Cortex of Anesthetized and Awake Macaques PLoS ONE 9(9) 1-8.
Safavi S, Kapoor V, Logothetis NK and Panagiotaropoulos TI (September-2014) Is the frontal lobe involved in conscious perception? Frontiers in Psychology 5(1063) 1-2.
Kadjane P, Platas-Iglesias C, Boehm-Sturm P, Truffault V, Hagberg GE, Hoehn M, Logothetis NK and Angelovski G (June-2014) Dual-Frequency Calcium-Responsive MRI Agents Chemistry: A European Journal 20(24) 7351–7362.
Marzo A, Totah NK, Neves RM, Logothetis NK and Eschenko O (June-2014) Unilateral electrical stimulation of rat locus coeruleus elicits bilateral response of norepinephrine neurons and sustained activation of medial prefrontal cortex Journal of Neurophysiology 111(12) 2570-2588.
Angelovski G, Gottschalk S, Milošević M, Engelmann J, Hagberg GE, Kadjane P, Andjus P and Logothetis NK (May-2014) Investigation of a Calcium-Responsive Contrast Agent in Cellular Model Systems: Feasibility for Use as a Smart Molecular Probe in Functional MRI ACS Chemical Neuroscience 5(5) 360–369.
Remedios R, Logothetis NK and Kayser C (April-2014) A role of the claustrum in auditory scene analysis by reflecting sensory change Frontiers in Systems Neuroscience 8(44) 1-8.
Musall S, von Pföstl V, Rauch A, Logothetis NK and Whittingstall K (April-2014) Effects of neural synchrony on surface EEG Cerebral Cortex 24(4) 1045-1053.
Papanikolaou A, Keliris GA, Papageorgiou TD, Shao Y, Krapp E, Papageorgiou E, Stingl K, Bruckmann A, Schiefer U, Logothetis NK and Smirnakis SM (April-2014) Population receptive field analysis of the primary visual cortex complements perimetry in patients with homonymous visual field defects Proceedings of the National Academy of Sciences of the United States of America 111(16) E1656–E1665.
Panagiotaropoulos TI, Kapoor V and Logothetis NK (March-2014) Subjective visual perception: From local processing to emergent phenomena of brain activity Philosophical Transactions of the Royal Society London B 369(1641) 1-13.
Perrodin C, Kayser C, Petkov CI and Logothetis NK (February-2014) Auditory and Visual Modulation of Temporal Lobe Neurons in Voice-Sensitive and Association Cortices Journal of Neuroscience 34(7) 2524-2537.
Hagberg G, Mamedov I, Power A, Beyerlein M, Merkle H, Kiselev VG, Dhingra K, Kubìček V, Angelovski G and Logothetis NK (January-2014) Diffusion properties of conventional and calcium-sensitive MRI contrast agents in the rat cerebral cortex Contrast Media & Molecular Imaging 9(1) 71–82.
Evrard HC, Logothetis NK and Bud Craig AD (January-2014) Modular architectonic organization of the insula in the macaque monkey Journal of Comparative Neurology 522(1) 64–97.
Dhingra Verma K, Forgács A, Uh H, Beyerlein M, Maier ME, Petoud S, Botta M and Logothetis NK (December-2013) New Calcium-Selective Smart Contrast Agents for Magnetic Resonance Imaging Chemistry - A European Journal 19(52) 18011–18026.
Herdener M, Esposito F, Scheffler K, Schneider P, Logothetis NK, Uludag K and Kayser C (December-2013) Spatial representations of temporal and spectral sound cues in human auditory cortex Cortex 49(10) 2822–2833.
Lee S, Papanikolaou A, Logothetis NK, Smirnakis SM and Keliris GA (November-2013) A new method for estimating population receptive field topography in visual cortex NeuroImage 81 144–157.
Einevoll GT, Kayser C, Logothetis NK and Panzeri S (November-2013) Modelling and analysis of local field potentials for studying the function of cortical circuits Nature Reviews Neuroscience 14(11) 770-785.
Watanabe M, Bartels A, Macke JH, Murayama Y and Logothetis NK (November-2013) Temporal Jitter of the BOLD Signal Reveals a Reliable Initial Dip and Improved Spatial Resolution Current Biology 23(21) 2146–2150.
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Last updated: Tuesday, 18.11.2014