Contact

Dr. Moritz Zaiss

Address: Spemannstr. 41
72076 Tübingen
Room number: 3.A.02
Phone: +49 7071 601 735
Fax: +49 7071 601 702
E-Mail: Moritz.Zaiss

 

Picture of Zaiss, Moritz, Dr.

Moritz Zaiss

Position: Project Leader  Unit: Scheffler

I work on CEST - MRI, this is an MRI technique that enables detection of proteins and metabolites in the body.

I am part of the EU Project GLINT
http://tuebingen.mpg.de/kybernetik-neuigkeiten-2/detail/article/krebsfrueherkennung-mit-glukose/134.html
http://www.eibir.org/news-2/eibir-news/new-eibir-supported-horizon-2020-projects/glint/
The promise of the technique is to give a subject a drink of soda with high sugar and see if tumors light up due to their enhanced metabolism.

Find my previous publications on pubmed  http://www.ncbi.nlm.nih.gov/pubmed/?term=moritz+zaiss

Find resources for CEST-MRI on my project page www.cest-sources.org

 

latest paper

Downfield-NOE-suppressed amide-CEST-MRI at 7 Tesla provides a unique contrast in human glioblastoma.
Magn Reson Med. 2016 Jan 27;
Authors: Zaiss M, Windschuh J, Goerke S, Paech D, Meissner JE, Burth S, Kickingereder P, Wick W, Bendszus M, Schlemmer HP, Ladd ME, Bachert P, Radbruch A

Abstract
PURPOSE: The chemical exchange saturation transfer (CEST) effect observed in brain tissue in vivo at the frequency offset 3.5 ppm downfield of water was assigned to amide protons of the protein backbone. Obeying a base-catalyzed exchange process such an amide-CEST effect would correlate with intracellular pH and protein concentration, correlations that are highly interesting for cancer diagnosis. However, recent experiments suggested that, besides the known aliphatic relayed-nuclear Overhauser effect (rNOE) upfield of water, an additional downfield rNOE is apparent in vivo resonating as well around +3.5 ppm. In this study, we present further evidence for the underlying downfield-rNOE signal, and we propose a first method that suppresses the downfield-rNOE contribution to the amide-CEST contrast. Thus, an isolated amide-CEST effect depending mainly on amide proton concentration and pH is generated.
METHODS: The isolation of the exchange mediated amide proton effect was investigated in protein model-solutions and tissue lysates and successfully applied to in vivo CEST images of 11 glioblastoma patients.
RESULTS: Comparison with gadolinium contrast enhancing longitudinal relaxation time-weighted images revealed that the downfield-rNOE-suppressed amide-CEST contrast forms a unique contrast that delineates tumor regions and show remarkable overlap with the gadolinium contrast enhancement.
CONCLUSION: Thus, suppression of the downfield rNOE contribution might be the important step to yield the amide proton CEST contrast originally aimed at. Magn Reson Med, 2016. © 2016 Wiley Periodicals, Inc.

MRI imaging of protein content, conformation and denaturation

pH-weighted MRI

MRI of metabolites via CEST

GlucoCEST

Degrees: Ph.D. in Physics

 

Education:

2004 – 2009: Physics, Ruprecht-Karls University, Heidelberg, Germany

2005: Teaching Assistant for software engineering lecture, Faculty for Informatics

2009: internship at Kirchhoff Institute of Physics, Heidelberg, Enss Lab, Solid state physics

2009-2010: graduate student at Ruprecht-Karls Universität in the
Dep. Medical Physics in Radiology,   German Cancer Research Center (DKFZ), Heidelberg

June 2010 Graduation: Master of Physics

February 2011-February 2014 Ph.D. student, stipendiary of Helmholtz-Community at DKFZ

January-May 2013: Research Stay at Vanderbilt University, Nashville, TN in Gochberg lab

supported by a stipend of DAAD

February 2014: Promotion in physics: Dr. rer. nat

 

Research:

2014-2016: Post-Doc and leader of the project group CEST imaging at DKFZ, Heidelberg

June 2015: Research Stay at Molecular Biology Center Torino, Silvio Aimes Lab

October-November 2015: Research Stay Utrecht Medical Center, Dennis Klomps Lab

since 2016: Post-Doc and leader of the project CEST imaging at MPI, Tübingen

 

Awards:

Young Investigator Award of the Journal of Magnetic Resonance (JMR) at ENC 2014, Boston

Gorter award 2013 (first prize) of the German chapter of the International Society for Magnetic Resonance in Medicine (ISMRM), Freiburg

 

Competitive Grants: DFG grant : qCEST- Quantitative  Chemical Exchange saturation transfer MR imaging of brain tumors at ultra high fields

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Talks (15):

Schuenke P, Paech D, Koehler C, Windschuh J, Bachert P, Ladd M, Schlemmer H-P, Radbruch A and Zaiss M (April-26-2017) Abstract Talk: T1ρ-weighted Dynamic Glucose Enhanced MRI, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA 517.
Goerke S, Zaiss M, Longo D, Garello F, Di Gregorio E, Breitling J, Ladd M and Bachert P (April-24-2017) Abstract Talk: CEST Signals of Lipids, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA 165.
Zaiss MW (April-23-2017) Invited Lecture: CEST Theory, Exchange, T1p, T2 Relationship, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA 44.
Golay X, Zaiss M, Thust S and Kim M (April-23-2017) Invited Lecture: GlycoCEST, GlucoCEST, pH Agents, Translation to Humans, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA 46.
Scheunke P, Paech D, Koehler C, Windschuh J, Bachert P, Ladd ME, Schlemmer H-P, Radbruch A and Zaiss M (March-28-2017) Abstract Talk: T1ρ-weighted Dynamic Glucose Enhanced MRI, 58th Experimental Nuclear Magnetic Resonance Conference (ENC 2017), Pacific Grove, CA, USA 33.
Zaiss M, Ehses P, Windschuh J and Scheffler K (October-1-2016) Abstract Talk: Be prepared, stay tuned and keep’em separated: CEST MRI in the human brain at 9.4 Tesla, 33rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2016), Wien, Austria, Magnetic Resonance Materials in Physics, Biology and Medicine, 29(Supplement 1) S263-S264.
Meissner J-E, Bauer C, Korzowski A, Zaiss M, Ladd ME and Bachert P (October-1-2016) Abstract Talk: Indirect detection of lactate using CEST in muscle at 7T, 33rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2016), Wien, Austria, Magnetic Resonance Materials in Physics, Biology and Medicine, 29(Supplement 1) S264-S265.
Breitling J, Goerke S, Zaiss M, Windschuh J, Klika KD and Bachert P (October-1-2016) Abstract Talk: Inhomogeneous magnetization transfer detection by dual frequency CEST spectroscopy, 33rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2016), Wien, Austria, Magnetic Resonance Materials in Physics, Biology and Medicine, 29(Supplement 1) S265-S266.
Mann P, Schuenke P, Zaiss M, Witte M, Mueller S, Ladd ME, Bachert P and Karger C (September-30-2016) Abstract Talk: A quantitative and accelerated R1q-based polymer gel dosimetry evaluation for dose verification in radiotherapy, 33rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2016), Wien, Austria, Magnetic Resonance Materials in Physics, Biology and Medicine, 29(Supplement 1) S195-S196.
Meissner J-E, Korzowski A, Zaiss M, Ladd ME and Bachert P (September-30-2016) Abstract Talk: Quantitative pulsed CEST at 7T in vivo, 33rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2016), Wien, Austria, Magnetic Resonance Materials in Physics, Biology and Medicine, 29(Supplement 1) S146-S147.
Zaiss M (September-8-2016) Invited Lecture: Molecular imaging using CEST MRI or “How to find an exoplanet”, 47. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik (DGMP 2016) / 19. Jahrestagung der Deutschen Sektion der International Society for Magnetic Resonance in Medicine (ISMRM-DS 2016), Würzburg, Germany.
Schuenke P, Koehler C, Korzowski A, Windschuh J, Bachert P, Ladd M, Mundiyanapurath S, Paech D, Bickelhaupt S, Bonekamp D, Schlemmer H-P, Radbruch A and Zaiss M (September-2016) Abstract Talk: Eine adiabatische Spin-Lock Methode für T1ρ-basierte dynamische Glukose-Bildgebung an Ultrahochfeld MR-Tomographen, 47. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik (DGMP 2016) / 19. Jahrestagung der Deutschen Sektion der International Society for Magnetic Resonance in Medicine (ISMRM-DS 2016), Würzburg, Germany 38-40.
Bauer C, Meissner J-E, Korzowski A, Zaiss M, Ladd M and Bachert P (September-2016) Abstract Talk: Indirekter Nachweis von Laktat in vivo mittels Chemical Exchange Saturation Transfer, 47. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik (DGMP 2016) / 19. Jahrestagung der Deutschen Sektion der International Society for Magnetic Resonance in Medicine (ISMRM-DS 2016), Würzburg, Germany 41-42.
Zaiss MW (March-8-2016) Invited Lecture: Unfolding the Power of CEST MRI, ISMRM Workshop on Ultra High Field MRI: Technological Advances & Clinical Applications, Heidelberg, Germany.
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Last updated: Monday, 22.05.2017