Contact

Dr. Moritz Zaiss

Address: Spemannstr. 41
72076 Tübingen
Room number: 3.B.06
Phone: +49 7071 601 735
Fax: +49 7071 601 702
E-Mail: Moritz.Zaiss

 

Picture of Zaiss, Moritz, Dr.

Moritz Zaiss

Position: Project Leader  Unit: Scheffler

Molecular MRI using chemical exchange saturation transfer at 9.4T and 3T

CEST MRI is regarded as an exciting topic in the field of biomedical imaging. Its major advantage is imaging of physiological and molecular information with spatial resolution comparable to that of conventional MRI. Correlations of CEST signals with protein content and protein structure, metabolite concentration (especially glucose), as well as pH have made CEST an interesting imaging modality for studies of cancer: Metabolic changes indicate tumor activity, Protein content is a measure of increased cellularity during tumor infiltration; furthermore, there is a correlation between gradients in pH and tumor migration.

Find previous publications on pubmed  http://www.ncbi.nlm.nih.gov/pubmed/?term=moritz+zaiss

 

Find resources for CEST-MRI on the project page www.cest-sources.org

 

latest work:

 

QUESP and QUEST revisited - fast and accurate quantitative CEST experiments. DOI: 10.1002/mrm.26813
T1ρ-weighted Dynamic Glucose-enhanced MR Imaging in the Human Brain DOI: doi.org/10.1148/radiol.2017162351

Fast magentization-prepared imaging readouts

For all CEST experiments the magnetization must be prepared by saturation which takes several seconds to build up. Subsequently this magentization state must be read out as quickly as possible before it is lost again. Thus, one major project that forms the basis of all subprojects is the development of fast imaging readouts.

Hand in hand with sequence development , evaluation must be refined; evaluation software is shared on our project webiste www.cest-sources.org.


glucoCEST

We are part of the EU Project GLINT
http://tuebingen.mpg.de/kybernetik-neuigkeiten-2/detail/article/krebsfrueherkennung-mit-glukose/134.html
http://www.eibir.org/news-2/eibir-news/new-eibir-supported-horizon-2020-projects/glint/
The promise of the technique is to give a subject a drink of soda with high sugar and see if tumors light up due to their enhanced metabolism. First applications in vivo showed glucoCEST signal enhancmenet in tumor areas, see our recent article.

 

protein CEST

CEST allows MRI imaging of protein content, conformation and denaturation. All of these might be interesting markers in brain tumors as well as other pathologies, especially in tumors it might overcome the need for contrast agents (see Figure 1). In addition, protein signals have a correlation with pH that is investitgated for use of a pH-weighted imaging.

 

Figure 1: Comparison of Gadolinium enhanced (left column) and 'Downfield NOE-suppressd amide-CEST effect' in human glioblastoma patients revealed that amide-CEST contrast forms a unique contrast that delineates tumor regions and show remarkable overlap with the gadolinium contrast enhancement.

Current position:

Post-Doc and leader of the project 'Molecular MRI using chemical exchange saturation transfer at 9.4T and 3T' at MPI, Tübingen

 

Degrees: Ph.D. in Physics

 

Education:

2004 – 2009: Physics, Ruprecht-Karls University, Heidelberg, Germany

2009-2010: graduate student at Ruprecht-Karls Universität in the
Dep. Medical Physics in Radiology,   German Cancer Research Center (DKFZ), Heidelberg

June 2010 Graduation: Master of Physics

February 2011-February 2014 Ph.D. student, stipendiary of Helmholtz-Community at DKFZ

January-May 2013: Research Stay at Vanderbilt University, Nashville, TN in Gochberg lab

supported by a stipend of DAAD

February 2014: Promotion in physics: Dr. rer. nat

 

Research:

2014-2016: Post-Doc and leader of the project group CEST imaging at DKFZ, Heidelberg

June 2015: Research Stay at Molecular Biology Center Torino, Silvio Aimes Lab

October-November 2015: Research Stay Utrecht Medical Center, Dennis Klomps Lab

since 2016: Post-Doc and leader of the project CEST imaging at MPI, Tübingen

 

Awards:

Young Investigator Award of the Journal of Magnetic Resonance (JMR) at ENC 2014, Boston

Gorter award 2013 (first prize) of the German chapter of the International Society for Magnetic Resonance in Medicine (ISMRM), Freiburg

 

Competitive Grants: DFG grant : qCEST- Quantitative  Chemical Exchange saturation transfer MR imaging of brain tumors at ultra high fields

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Posters (16):

Zaiss M, Ivchenko O and Bachert P (May-10-2012): Spillover correction for quantification of pulsed-CEST experiments, 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia.
Ivchenko O, Imhof P, Zaiss M and Bachert P (May-10-2012): Studies of Quantum Mechanics/Molecular mechanics of small metabolites for quantification of chemical exchange saturation transfer, 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia.

Talks (15):

Zaiss M (August-7-2017) Abstract Talk: Basics of AREX and Inverse Correction Methods, Music City CEST 2017: Chemical Exchange Saturation Transfer Symposium, Nashville, TN, USA.
Schuenke P, Paech D, Koehler C, Windschuh J, Bachert P, Ladd M, Schlemmer H-P, Radbruch A and Zaiss M (April-26-2017) Abstract Talk: T1ρ-weighted Dynamic Glucose Enhanced MRI, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA 517.
Goerke S, Zaiss M, Longo D, Garello F, Di Gregorio E, Breitling J, Ladd M and Bachert P (April-24-2017) Abstract Talk: CEST Signals of Lipids, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA 165.
Zaiss MW (April-23-2017) Invited Lecture: CEST Theory, Exchange, T1p, T2 Relationship, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA 44.
Golay X, Zaiss M, Thust S and Kim M (April-23-2017) Invited Lecture: GlycoCEST, GlucoCEST, pH Agents, Translation to Humans, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA 46.
Scheunke P, Paech D, Koehler C, Windschuh J, Bachert P, Ladd ME, Schlemmer H-P, Radbruch A and Zaiss M (March-28-2017) Abstract Talk: T1ρ-weighted Dynamic Glucose Enhanced MRI, 58th Experimental Nuclear Magnetic Resonance Conference (ENC 2017), Pacific Grove, CA, USA 33.
Zaiss M, Ehses P, Windschuh J and Scheffler K (October-1-2016) Abstract Talk: Be prepared, stay tuned and keep’em separated: CEST MRI in the human brain at 9.4 Tesla, 33rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2016), Wien, Austria, Magnetic Resonance Materials in Physics, Biology and Medicine, 29(Supplement 1) S263-S264.
Meissner J-E, Bauer C, Korzowski A, Zaiss M, Ladd ME and Bachert P (October-1-2016) Abstract Talk: Indirect detection of lactate using CEST in muscle at 7T, 33rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2016), Wien, Austria, Magnetic Resonance Materials in Physics, Biology and Medicine, 29(Supplement 1) S264-S265.
Breitling J, Goerke S, Zaiss M, Windschuh J, Klika KD and Bachert P (October-1-2016) Abstract Talk: Inhomogeneous magnetization transfer detection by dual frequency CEST spectroscopy, 33rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2016), Wien, Austria, Magnetic Resonance Materials in Physics, Biology and Medicine, 29(Supplement 1) S265-S266.
Mann P, Schuenke P, Zaiss M, Witte M, Mueller S, Ladd ME, Bachert P and Karger C (September-30-2016) Abstract Talk: A quantitative and accelerated R1q-based polymer gel dosimetry evaluation for dose verification in radiotherapy, 33rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2016), Wien, Austria, Magnetic Resonance Materials in Physics, Biology and Medicine, 29(Supplement 1) S195-S196.
Meissner J-E, Korzowski A, Zaiss M, Ladd ME and Bachert P (September-30-2016) Abstract Talk: Quantitative pulsed CEST at 7T in vivo, 33rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2016), Wien, Austria, Magnetic Resonance Materials in Physics, Biology and Medicine, 29(Supplement 1) S146-S147.
Zaiss M (September-8-2016) Invited Lecture: Molecular imaging using CEST MRI or “How to find an exoplanet”, 47. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik (DGMP 2016) / 19. Jahrestagung der Deutschen Sektion der International Society for Magnetic Resonance in Medicine (ISMRM-DS 2016), Würzburg, Germany.
Schuenke P, Koehler C, Korzowski A, Windschuh J, Bachert P, Ladd M, Mundiyanapurath S, Paech D, Bickelhaupt S, Bonekamp D, Schlemmer H-P, Radbruch A and Zaiss M (September-2016) Abstract Talk: Eine adiabatische Spin-Lock Methode für T1ρ-basierte dynamische Glukose-Bildgebung an Ultrahochfeld MR-Tomographen, 47. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik (DGMP 2016) / 19. Jahrestagung der Deutschen Sektion der International Society for Magnetic Resonance in Medicine (ISMRM-DS 2016), Würzburg, Germany 38-40.
Bauer C, Meissner J-E, Korzowski A, Zaiss M, Ladd M and Bachert P (September-2016) Abstract Talk: Indirekter Nachweis von Laktat in vivo mittels Chemical Exchange Saturation Transfer, 47. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik (DGMP 2016) / 19. Jahrestagung der Deutschen Sektion der International Society for Magnetic Resonance in Medicine (ISMRM-DS 2016), Würzburg, Germany 41-42.
Zaiss MW (March-8-2016) Invited Lecture: Unfolding the Power of CEST MRI, ISMRM Workshop on Ultra High Field MRI: Technological Advances & Clinical Applications, Heidelberg, Germany.
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Last updated: Monday, 22.05.2017