Contact

Dr. Moritz Zaiss

Address: Spemannstr. 41
72076 Tübingen
Room number: 3.B.06
Phone: +49 7071 601 735
Fax: +49 7071 601 702
E-Mail: Moritz.Zaiss

 

Picture of Zaiss, Moritz, Dr.

Moritz Zaiss

Position: Project Leader  Unit: Scheffler

Molecular MRI using chemical exchange saturation transfer at 9.4T and 3T

CEST MRI is regarded as an exciting topic in the field of biomedical imaging. Its major advantage is imaging of physiological and molecular information with spatial resolution comparable to that of conventional MRI. Correlations of CEST signals with protein content and protein structure, metabolite concentration (especially glucose), as well as pH have made CEST an interesting imaging modality for studies of cancer: Metabolic changes indicate tumor activity, Protein content is a measure of increased cellularity during tumor infiltration; furthermore, there is a correlation between gradients in pH and tumor migration.

Find previous publications on pubmed  http://www.ncbi.nlm.nih.gov/pubmed/?term=moritz+zaiss

 

Find resources for CEST-MRI on the project page www.cest-sources.org

 

latest work:

 

QUESP and QUEST revisited - fast and accurate quantitative CEST experiments. DOI: 10.1002/mrm.26813
T1ρ-weighted Dynamic Glucose-enhanced MR Imaging in the Human Brain DOI: doi.org/10.1148/radiol.2017162351

Fast magentization-prepared imaging readouts

For all CEST experiments the magnetization must be prepared by saturation which takes several seconds to build up. Subsequently this magentization state must be read out as quickly as possible before it is lost again. Thus, one major project that forms the basis of all subprojects is the development of fast imaging readouts.

Hand in hand with sequence development , evaluation must be refined; evaluation software is shared on our project webiste www.cest-sources.org.


glucoCEST

We are part of the EU Project GLINT
http://tuebingen.mpg.de/kybernetik-neuigkeiten-2/detail/article/krebsfrueherkennung-mit-glukose/134.html
http://www.eibir.org/news-2/eibir-news/new-eibir-supported-horizon-2020-projects/glint/
The promise of the technique is to give a subject a drink of soda with high sugar and see if tumors light up due to their enhanced metabolism. First applications in vivo showed glucoCEST signal enhancmenet in tumor areas, see our recent article.

 

protein CEST

CEST allows MRI imaging of protein content, conformation and denaturation. All of these might be interesting markers in brain tumors as well as other pathologies, especially in tumors it might overcome the need for contrast agents (see Figure 1). In addition, protein signals have a correlation with pH that is investitgated for use of a pH-weighted imaging.

 

Figure 1: Comparison of Gadolinium enhanced (left column) and 'Downfield NOE-suppressd amide-CEST effect' in human glioblastoma patients revealed that amide-CEST contrast forms a unique contrast that delineates tumor regions and show remarkable overlap with the gadolinium contrast enhancement.

Current position:

Post-Doc and leader of the project 'Molecular MRI using chemical exchange saturation transfer at 9.4T and 3T' at MPI, Tübingen

 

Degrees: Ph.D. in Physics

 

Education:

2004 – 2009: Physics, Ruprecht-Karls University, Heidelberg, Germany

2009-2010: graduate student at Ruprecht-Karls Universität in the
Dep. Medical Physics in Radiology,   German Cancer Research Center (DKFZ), Heidelberg

June 2010 Graduation: Master of Physics

February 2011-February 2014 Ph.D. student, stipendiary of Helmholtz-Community at DKFZ

January-May 2013: Research Stay at Vanderbilt University, Nashville, TN in Gochberg lab

supported by a stipend of DAAD

February 2014: Promotion in physics: Dr. rer. nat

 

Research:

2014-2016: Post-Doc and leader of the project group CEST imaging at DKFZ, Heidelberg

June 2015: Research Stay at Molecular Biology Center Torino, Silvio Aimes Lab

October-November 2015: Research Stay Utrecht Medical Center, Dennis Klomps Lab

since 2016: Post-Doc and leader of the project CEST imaging at MPI, Tübingen

 

Awards:

Young Investigator Award of the Journal of Magnetic Resonance (JMR) at ENC 2014, Boston

Gorter award 2013 (first prize) of the German chapter of the International Society for Magnetic Resonance in Medicine (ISMRM), Freiburg

 

Competitive Grants: DFG grant : qCEST- Quantitative  Chemical Exchange saturation transfer MR imaging of brain tumors at ultra high fields

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Articles (35):

Bailey DL, Pichler BJ, Gückel B, Antoch G, Barthel H, Bhujwalla ZM, Biskup S, Biswal S, Bitzer M, Boellaard R, Braren RF, Brendle C, Brindle K, Chiti A, la Fougère C, Gillies R, Goh V, Goyen M, Hacker M, Heukamp L, Knudsen GM, Krackhardt AL, Law I, Morris CJ, Nikolaou K, Nuyts J, Ordonez AA, Pantel K, Quick HH, Riklund K, Sabri O, Sattler B, Troost EGC, Zaiss M, Zender L and Beyer T (October-2017) Combined PET/MRI: Global Warming: Summary Report of the 6th International Workshop on PET/MRI, March 27–29, 2017, Tübingen, Germany Molecular Imaging and Biology Epub ahead.
Kunz P, Flock T, Soler N, Zaiss M, Vincke C, Sterckx Y, Kastelic D, Muyldermans S and Hoheisel JE (September-2017) Exploiting sequence and stability information for directing nanobody stability engineering Biochimica et Biophysica Acta: General Subjects 1861(9) 2196–2205.
Schuenke P, Koehler C, Korzowski A, Windschuh J, Bachert P, Ladd ME, Mundiyanapurath S, Paech D, Bickelhaupt S, Bonekamp D, Schlemmer H-P, Radbruch A and Zaiss M (July-2017) Adiabatically prepared spin-lock approach for T1ρ-based dynamic glucose enhanced MRI at ultrahigh fields Magnetic Resonance in Medicine 78(1) 215-225.
Müller-Lutz A, Cronenberg T, Schlaich C, Wickrath F, Zaiss M, Boos J and Wittsack H-J (July-2017) Comparison of glycosaminoglycan chemical exchange saturation transfer using Gaussian-shaped and off-resonant spin-lock radiofrequency pulses in intervertebral disks Magnetic Resonance in Medicine 78(1) 280-284.
Zaiss M, Angelovski G, Demetriou E, McMahon MT, Golay X and Scheffler K (July-2017) QUESP and QUEST revisited: fast and accurate quantitative CEST experiments Magnetic Resonance in Medicine Epub ahead.
Cakić N, Tickner B, Zaiss M, Esteban-Gómez D, Platas-Iglesias C and Angelovski G (July-2017) Spectrally Undiscerned Isomers Might Lead to Erroneous Determination of Water Exchange Rates of paraCEST Eu(III) Agents Inorganic Chemistry 56(14) 7737–7745.
Paech D, Schuenke P, Koehler C, Windschuh J, Mundiyanapurath S, Bickelhaupt S, Bonekamp D, Bäumer P, Bachert P, Ladd ME, Bendszus M, Wick W, Unterberg A, Schlemmer HP, Zaiss M and Radbruch A (June-2017) T1ρ-weighted Dynamic Glucose-enhanced MR Imaging in the Human Brain Radiology Epub ahead.
Schuenke P, Paech D, Koehler C, Windschuh J, Bachert P, Ladd ME, Schlemmer H-P, Radbruch A and Zaiss M (February-2017) Fast and Quantitative T1ρ-weighted Dynamic Glucose Enhanced MRI Scientific Reports 7(42093) 1-10.
Schuenke P, Windschuh J, Roeloffs V, Ladd ME, Bachert P and Zaiss M (February-2017) Simultaneous mapping of water shift and B1(WASABI)-Application to field-Inhomogeneity correction of CEST MRI data Magnetic Resonance in Medicine 77(2) 571–580.
Goerke S, Milde KS, Bukowiecki R, Kunz P, Klika KD, Wiglenda T, Mogk K, Wanker EE, Bukau E, Ladd ME, Bachert P and Zaiss M (January-2017) Aggregation-induced changes in the chemical exchange saturation transfer (CEST) signals of proteins NMR in Biomedicine 30(1) 1-9.
Zaiss M, Windschuh J, Goerke S, Paech D, Meissner J-E, Burth S, Kickingereder P, Wick W, Bendszus M, Schlemmer H-P, Ladd ME, Bachert P and Radbruch A (January-2017) Downfield-NOE-suppressed amide-CEST-MRI at 7 Tesla provides a unique contrast in human glioblastoma Magnetic Resonance in Medicine 77(1) 196–208.
Wu B, Warnock G, Zaiss M, Lin C, Chen M, Zhou Z, Mu L, Nanz D, Tuura R and Delso G (August-2016) An overview of CEST MRI for non-MR physicists EJNMMI Physics 3(18) 1-21.
Li H, Li K, Zhang X-Y, Jiang X, Zhu Z, Zaiss M, Gochberg DF, Gore JC and Xu J (December-2015) R1 correction in amide proton transfer imaging: indication of the influence of transcytolemmal water exchange on CEST measurements NMR in Biomedicine 28(12) 1655–1662.
Rerich E, Zaiss M, Korzowski A, Ladd ME and Bachert P (November-2015) Relaxation-compensated CEST-MRI at 7 T for mapping of creatine content and pH – preliminary application in human muscle tissue in vivo NMR in Biomedicine 28(11) 1402–1412.
Meissner J-E, Goerke S, Berich E, Klika KD, Radbruch A, Ladd ME, Bachert P and Zaiss M (October-2015) Quantitative pulsed CEST-MRI using Ω-plots NMR in Biomedicine 28(10) 1196–1208.
Bodet O, Goerke S, Behl NGR, Roeloffs V, Zaiss M and Bachert P (September-2015) Amide proton transfer of carnosine in aqueous solution studied in vitro by WEX and CEST experiments NMR in Biomedicine 28(9) 1097–1103.
Goerke S, Zaiss M, Kunz P, Klika KD, Windschuh JD, Mogk A, Bukau B, Ladd ME and Bachert P (July-2015) Signature of protein unfolding in chemical exchange saturation transfer imaging NMR in Biomedicine 28(7) 906–913.
Windschuh J, Zaiss M, Meissner J-E, Paech D, Radbruch A, Ladd ME and Bachert P (May-2015) Correction of B1-inhomogeneities for relaxation-compensated CEST imaging at 7 T NMR in Biomedicine 28(5) 529–537.
Zaiss M, Windschuh J, Paech D, Meissner J-E, Burth S, Schmitt B, Kickingereder P, Wiestler B, Wick W, Bendszus M, Schlemmer H-P, Ladd ME, Bachert P and Radbruch A (May-2015) Relaxation-compensated CEST-MRI of the human brain at 7 T: Unbiased insight into NOE and amide signal changes in human glioblastoma NeuroImage 112 180–188.
Paech D, Burth S, Windschuh J, Meissner J-E, Zaiss M, Eidel O, Kickingereder P, Nowosielski M, Wiestler B, Sahm F, Floca RO, Neumann J-O, Wick W, Heiland S, Bendszus M, Schlemmer H-P, Ladd ME, Bachert P and Radbruch A (March-2015) Nuclear Overhauser Enhancement Imaging of Glioblastoma at 7 Tesla: Region Specific Correlation with Apparent Diffusion Coefficient and Histology PLoS ONE 10(3) 1-16.
Zaiss M, Zu J, Xu J, Schuenke P, Gochberg DF, Gore JC, Ladd ME and Bachert P (February-2015) A combined analytical solution for chemical exchange saturation transfer and semi-solid magnetization transfer NMR in Biomedicine 28(2) 217–230.
Li H, Zu Z, Zaiss M, Khan IS, Singer RJ, Gochberg DF, Bachert P, Gore JC and Xu J (February-2015) Imaging of amide proton transfer and nuclear Overhauser enhancement in ischemic stroke with corrections for competing effects NMR in Biomedicine 28(2) 200–209.
Roeloffs V, Meyer C, Bachert P and Zaiss M (January-2015) Towards quantification of pulsed spinlock and CEST at clinical MR scanners: an analytical interleaved saturation–relaxation (ISAR) approach NMR in Biomedicine 28(1) 40–53.
Paech D, Zaiss M, Meissner J-E, Windschuh J, Wiestler B, Bachert P, Neumann JO, Kickingereder P, Schlemmer H-P, Wick W, Nagel AM, Heiland S, Ladd ME, Bendszus M and Radbruch A (August-2014) Nuclear Overhauser Enhancement Mediated Chemical Exchange Saturation Transfer Imaging at 7 Tesla in Glioblastoma Patients PLoS ONE 9(8) 1-7.
Döpfert J, Zaiss M, Witte C and Schröder L (June-2014) Ultrafast CEST imaging Journal of Magnetic Resonance 243 47–53.
Goerke S, Zaiss M and Bachert P (May-2014) Characterization of creatine guanidinium proton exchange by water-exchange (WEX) spectroscopy for absolute-pH CEST imaging in vitro NMR in Biomedicine 27(5) 507–518.
Xu J, Zaiss M, Zu J, Li H, Xie J, Gochberg DF, Bachert P and Gore JC (April-2014) On the origins of chemical exchange saturation transfer (CEST) contrast in tumors at 9.4 T NMR in Biomedicine 27(4) 406–416.
Zaiss M, Xu J, Goerke S, Khan IS, Singer RJ, Gore JC, Gochberg DF and Bachert P (March-2014) Inverse Z-spectrum analysis for spillover-, MT-, and T1-corrected steady-state pulsed CEST-MRI: application to pH-weighted MRI of acute stroke NMR in Biomedicine 27(3) 240–252.
Zaiss M, Kunz P, Goerke S, Radbruch A and Bachert P (December-2013) MR imaging of protein folding in vitro employing Nuclear-Overhauser-mediated saturation transfer NMR in Biomedicine 26(12) 1815–1822.
Zaiss M and Bachert P (November-2013) Chemical exchange saturation transfer (CEST) and MR Z-spectroscopy in vivo: a review of theoretical approaches and methods Physics in Medicine and Biology 58(22) R221-R269.
Zaiss M and Bachert P (May-2013) Exchange-dependent relaxation in the rotating frame for slow and intermediate exchange – modeling off-resonant spin-lock and chemical exchange saturation transfer NMR in Biomedicine 26(5) 507–518.
Gaass T, Dinkel J, Bauman G, Zaiss M, Hintze C, Haase A and Laun F (August-2012) Non-contrast-enhanced MRI of the pulmonary blood volume using two-compartment-modeled T1-relaxation Journal of Magnetic Resonance Imaging 36(2) 397–404.
Zaiss M, Schnurr M and Bachert P (April-2012) Analytical solution for the depolarization of hyperpolarized nuclei by chemical exchange saturation transfer between free and encapsulated xenon (HyperCEST) Journal of Chemical Physics 136(14:144106) 1-10.
Zaiss M, Schmitt B and Bachert P (August-2011) Quantitative separation of CEST effect from magnetization transfer and spillover effects by Lorentzian-line-fit analysis of z-spectra Journal of Magnetic Resonance 211(2) 149–155.
Schmitt B, Zaiss M, Zhou J and Bachert P (June-2011) Optimization of pulse train presaturation for CEST imaging in clinical scanners Magnetic Resonance in Medicine 65(6) 1620–1629.

Conference papers (1):

Zaiss M, Goerke S, Xu J, Khan IS, Singer RJ, Gore JC, Gochberg DF and Bachert P (September-2013) Exchange-dependent relaxation in the rotating frame for slow and intermediate exchange: Modeling off-resonant spin-lock and chemical exchange saturation transfer, 16. Jahrestagung Deutschen Sektion der ISMRM e.V. (DS ISMRM 2013), 35-39.

Posters (16):

Zaiss M, Angelovski G, Demetriou E, McMahon MT, Golay X and Scheffler K (October-21-2017): QUESP and QUEST revisited: a more complete theory for quantification of chemical exchange saturation transfer experiments, 34th Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2017), Barcelona, Spain, Magnetic Resonance Materials in Physics, Biology and Medicine, 30(Supplement 1) S398-S399.
Herz K, Zaiss M and Scheffler K (October-19-2017): Optimized adiabatic spin-lock pulses for robust dynamic glucose enhanced MRI at 3T, 34th Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2017), Barcelona, Spain, Magnetic Resonance Materials in Physics, Biology and Medicine, 30(Supplement 1) S87-S88.
Zaiss M (August-7-2017): Quantification of hydroxyl exchange of D-Glucose at physiological conditions for optimization of glucoCEST MRI, Music City CEST 2017: Chemical Exchange Saturation Transfer Symposium, Nashville, TN, USA.
Paech D, Schuenke P, Koehler C, Windschuh J, Mundiyanapurath S, Bickelhaupt S, Bäumer P, Bonekamp D, Bendszus M, Wick W, Bachert P, Ladd M, Schlemmer H-P, Zaiss M and Radbruch A (April-27-2017): Dynamic Glucose Enhanced MRI: A prospective study in healthy volunteers and glioblastoma patients, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Goerke S, Windschuh J, Zaiss M, Meissner J-E, Ladd M and Bachert P (April-25-2017): Elegant method to quantify chemical exchange processes for pH CEST imaging, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Khlebnikov V, Windschuh J, Siero JCW, Zaiss M, Luijten PR, Klomp DWJ and Hoogduin H (April-25-2017): The comparison of different strategies for transmit field inhomogeneity correction of Amide-CEST and NOE effects at 7T, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Zaiss M, Ehses P and Scheffler K (April-24-2017): 3D Quantitative CEST MRI of the human brain at 9.4T, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Krikken E, Khlebnikov V, Zaiss M, van der Kemp WJM, van der Velden TA, van Laarhoven HWM, Klomp DWJ and Wijnen JP (April-24-2017): Monitoring neoadjuvant chemotherapy in breast cancer patients using CEST and 31P-MRS at 7 tesla, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Zaiss M, Ehses P and Scheffler K (April-24-2017): snapCEST: A single-shot 3D CEST sequence for motion corrected CEST MRI, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Windschuh J, Meissner J-E, Schuenke P, Zaiss M, Ladd M and Bachert P (September-2016): Charakterisierung der CEST-Signale von Gelatine, 47. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik (DGMP 2016) / 19. Jahrestagung der Deutschen Sektion der International Society for Magnetic Resonance in Medicine (ISMRM-DS 2016), Würzburg, Germany.
Zaiss M and Bachert P (May-2013): MTRRex: a spillover correction for pulsed steady-state CEST, 3rd International Workshop on Chemical Exchange Saturation Transfer Imaging (OctoberCEST 2012), Annapolis, MD, USA, Contrast Media & Molecular Imaging, 8(3) 315-316.
Roeloffs VR, Zaiss M and Bachert P (April-23-2013): An Analytical Approach Towards Pulsed-SL/CEST Quantification, 21st Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT, USA.
Zaiss M, Goerke S and Bachert P (April-23-2013): MTRRex: a New Spillover and MT Correction Method for Quantitative Pulsed Steady-State CEST, 21st Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT, USA.
Zaiss M and Bachert P (May-10-2012): Rescalable spillover prediction for optimization of pulsed magnetization transfer and CEST experiments, 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia.
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Last updated: Monday, 22.05.2017