Contact

Maosen Wang

Address: Spemannstr. 41
72076 Tuebingen
Room number: 3.B.08
Phone: +49 7071 601 738
Fax: +49 7071 601 701
E-Mail: Maosen.Wang

 

Picture of Wang, Maosen

Maosen Wang

Position: PhD Student  Unit: Yu Scheffler

Functional magnetic resonance imaging (fMRI) based on blood oxygen level–dependent (BOLD) contrast is widely used for probing brain activity1. Neurovascular coupling constitutes the physiological basis for BOLD2, 3. Neurons, astrocytes and vessels cells are the main components of the neurovascular unit and work in concert to maintain the homeostasis of the brain microenvironment4, 5. The anatomical techniques demonstrated that astrocytes were connected the synaptic cleft with smooth muscle cells through multiple end feet. The morphology of astrocytes place them as likely a potential mediator, relaying synaptic activity between neurons and vasculature6. The goal of my doctoral project is to identify the astrocytic contribution to the BOLD fMRI signal  by simultaneous BOLD fMRI and neuronal/astrocytic calcium signal recording.

 

 

Reference

1.  Schulz, K. et al. Simultaneous BOLD fMRI and fiber-optic calcium recording in rat neocortex. Nat Methods 9, 597-602 (2012).

2.  Attwell, D. & Iadecola, C. The neural basis of functional brain imaging signals. Trends in Neurosciences 25, 621-625 (2002).

3.  Logothetis, N.K. & Wandell, B.A. Interpreting the BOLD signal. Annual Review of Physiology 66, 735-769 (2004).

4.  Attwell, D. et al. Glial and neuronal control of brain blood flow.Nature 468, 232-43 (2010).

5.  Zonta, M. et al. Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nature Neuroscience 6, 43-50 (2003).

6.  Wolf, F. & Kirchhoff, F. Neuroscience. Imaging astrocyte activity.Science 320, 1597-9 (2008).


Education

Since 01/2014: PhD student in the Graduate School of Neural & Behavioural Sciences / International Max Planck Research School at the High-Field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics(Supervisor:Dr Xin Yu).

2010 – 2013 : Master of Science in Biophysics (Neuroscience), School of Life Science and Technology, University of Electronic Science and Technology of China. Chengdu, Sichuan, China.

2006 – 2010: Bachelor of Science in Biotechnology, School of Life Science, Northwest Normal University, Lanzhou, Gansu, China.

 

HONORS AND AWARDS

2017    Summa Cum Laude Merit Award (ISMRM, top 5%), Honolulu, USA

2016    Outstanding poster award, Gordon Research Conferences in vivo MR, Andover, USA

2014    Scholarship from International Max Planck Research School for doctoral project, Max Planck Society, Germany

 

MEMBERSHIPS OF SCIENTIFIC SOCIETIES

2014 - Present    Trainee Member, International Society for Magnetic Resonance in Medicine (ISMRM)

2017- Present     Student member, Society for Neuroscience

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Show abstracts

Articles (1):

Yu X, He Y, Wang M, Merkle H, Dodd SJ, Silva AC and Koretsky AP (April-2016) Sensory and optogenetically driven single-vessel fMRI Nature Methods 13(4) 337-340.

Posters (5):

He Y, Wang M, Chen X and Yu X (April-27-2017): Identify the neural basis of vascular dynamic network connectivity with high-field fMRI, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Wang M, He Y and Yu X (April-25-2017): A novel role of intrinsic astrocytic calcium spikes to mediate brain states through central/dorsal thalamic nuclei, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Wang M, He Y, Tang Y, Merkle H and Yu X (June-3-2015): Identify the “single unit” of neurovascular coupling by single-vessel fMRI and optogenetics, 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.
Wang M, He Y, Tang Y, Balla DZ, Qian C and Yu X (June-3-2015): Map the light-driven fMRI signal in combination with in vivo recording, 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.
Wang M, He Y, Tang Y, Balla D and Yu X (March-19-2015): Light-driven fMRI and Electrophysiological Responses in Rat Brain, 10th Annual Meeting of the European Society for Molecular Imaging (EMIM 2015), Tübingen, Germany.

Talks (4):

Wang H, He Y, Sejnowski TJ and Yu X (November-15-2017) Abstract Talk: Decipher the concurrent bidirectional regulation of the fMRI signal by astrocytes, 47th Annual Meeting of the Society for Neuroscience (Neuroscience 2017), Washington, DC, USA.
Wang M, He Y and Yu X (April-24-2017) Abstract Talk: Simultaneous fMRI with GCaMP6-mediated neuronal and astrocytic calcium signal recording, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA 122.
Wang M (February-21-2017) Abstract Talk: A novel role of intrinsic astrocytic calcium spikes to mediate brain states through thalamocortical pathway, 11th ESMI Winter Conference "hot TOPIics in IMaging" (TOPIM 2017), Les Houches, France.
Wang M, He Y, Engelmann J and Yu X (September-2016) Abstract Talk: Decipher the neuronal and astrocytic calcium signal coupling with fMRI, 17th Conference of Junior Neuroscientists of Tübingen (NeNa 2016): Neuroscience & Law, Schramberg, Germany 12.

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Last updated: Monday, 22.05.2017