Contact

Mario Baez

Address: Spemannstr. 41
72076 Tübingen
Room number: 3.B.10
Phone: +49 7071 601 942
Fax: +49 7071 601 702
E-Mail: Mario.Baez

 

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Mario Baez

Position: PhD Student  Unit: Scheffler

Biomedical Engineer
PhD Student at Max Planck Institute for Biological Cybernetics

Sequences and Signals, Signal Formation, fMRI & Monte-Carlo Simulations

Measurement and Simulation of SSFP signal formation in Neurovascular Tissue at 9.4 T

Biological tissues have a complicated chemical composition and geometrical architecture that influence the MR signal formation. In the presence of an external magnetic field, differences in magnetic susceptibilities between adjacent compartments generate local magnetic field perturbations, and hence a range of magnetic resonance frequency shifts. In addition, the use of SSFP acquisition sequence in a fMRI experiment and the relation of the MR signal at microscopic scales is poorly understood. Aiming to understand the brain function and its relation with the MR signal, computer simulations supply valuable information to clarify this MR signal formation under realistic tissue properties scheme in both health and disease.

Field perturbations generated by spheres (10 μm radii) or real microCT capillaries data. The blood volume in both cases is 2% and a susceptibility difference between the external and internal medium of 1x10-7 cgs. Sketch of a 3D proton’s random walk through local magnetic field inhomogeneities ΔBz generated by the spherical perturbers or the capillaries. Representation of the signal in the steady-state after 200 ms excitation. (TR = 20 ms, TE = TR/2, T1 = 590 ms, T2 = 490 ms)

a) Field perturbations generated by spheres (10 μm radii) or real microCT capillaries data. The blood
volume in both cases is 2% and a susceptibility difference between the external and internal medium of 1x10-7 cgs. b) Sketch of a 3D proton’s random walk through local magnetic field inhomogeneities ΔBz generated by the spherical perturbers or the capillaries. c) Representation of the signal in the steady-state after 200 ms excitation. (TR = 20 ms, TE = TR/2, T1 = 590 ms, T2 = 490 ms)

  • Ph.D. Student, Prof. K. Scheffler, High-Field Magnetic Resonance, Magnetic Resonance Center, MPI for Biological Cybernetics, Germany, Nov 2013-
  • Intership, Prof. P. Tobler, Neuroeconomics, Department of Economics, University of Zurich, Switzerland, Sept 2012 -Nov 2012.
  • Master of Science in Biomedical Engineer, Prof. G. Pacheco-Lopez, Autonomous Metropolitan University, Mexico, April 2011 – July 2013
  • Biomedical Engineer, Autonomous Metropolitan University, Mexico, January 2007 – March 2011

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Articles (2):

Báez-Yánez MG, Ehses P, Mirkes C, Tsai PS, Kleinfeld D and Scheffler K (September-2017) The impact of vessel size, orientation and intravascular contribution on the neurovascular fingerprint of BOLD bSSFP fMRI NeuroImage 163 13–23.
Montiel-Castro AJ, Baez-Yanez MG and Pacheco-Lopez G (July-2014) Social Neuroeconomics: The Influence of Microbiota in Partner-Choice and Sociality Current Pharmaceutical Design 20(29) 4774-4783.

Posters (3):

Ehses P, Báez-Yánez M, Erb M and Scheffler K (April-27-2017): Asymmetries of the balanced SSFP profile allow to probe microstructure anisotropy at 9.4 Tesla, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Báez-Yánez M, Ehses P and Scheffler K (April-27-2017): The Impact of the Local, Mesoscopic Frequency Distribution and Diffusion in Gray and White Matter to the Static bSSFP Signal Profile, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Scheffler K, Kleinfeld D, Tsai P, Báez-Yánez M and Ehses P (April-27-2017): The neurovascular fingerprint of BOLD bSSFP: the impact of vessel size, orientation and intravascular contribution, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.

Talks (1):

Baez Yanez MG, Ehses P and Scheffler K (May-12-2016) Abstract Talk: The BOLD-sensitivity of balanced SSFP at very high fields is similar to GE-EPI but more selective to small vessels, 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016), Singapore(0949).

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Last updated: Monday, 22.05.2017