Contact

Joana Loureiro

Address: Spemannstr. 41
72076 Tübingen
Room number: 3.B.03
Phone: +49 7071 601 1648
Fax: +49 7071 601 702
E-Mail: Joana.Loureiro

 

Picture of Loureiro, Joana

Joana Loureiro

Position: PhD Student  Unit: Scheffler

We are exploiting the potential of UHF imaging for submillimetre fMRI in a series of experiments addressing the functional organisation of the human superior colliculi.

 

There are three reasons why we chose this anatomical structure for our project:

1) the anatomical architecture of the tectum calls for high-resolution imaging to distinguish between the functional properties of individual layers,

2) from monkey studies there is a good knowledge about the functional properties that should be found, so we have very clear working hypotheses for our individual experiments,

3) although we have all this detailed knowledge from non-human primates, virtually nothing has been confirmed in humans. In fact, for most other structures of the brainstem it is rather unclear whether the functional anatomy is indeed almost identical with the organisation in macaques or whether there are substantial differences. Some recent work published by neuroanatomist showed that more differences might exist than we thought.

 

The project's specific aims are threefold: establishing anatomical sequences that allow us to identify brainstem nuclei with isotropic submillimeter resolution; establishing functional sequences to acquire blood oxygen level dependent (BOLD) signals with isotropic submillimeter resolution in the brainstem; detecting BOLD signals induced by visual stimulation, auditory stimulation and oculomotor activity in the superior colliculi (SC) using slow event-related designs. We strive for a localisation of induced signals in terms of different layers of the superior colliculi in a representative group study.

 

Starting on January 2015 this project will be funded by the Carl Zeiss Stiftung (http://carl-zeiss-stiftung.de/96-0-gefoerderte-Doktorandeninnen-2014.html) and it was previously funded by the Centre for Integrative Neurosciences in Tuebingen (CIN).

Current Position: Anatomy and Functional MRI of the Human Midbrain at 9,4T, MPI for Biological Cybernetics and UKT, Tuebingen, Germany

 

Development and Application of Advanced Techniques to Study Cerebral Human Connectivity in Rest: DMN identification in Schizophrenic patients and healthy control subjects using fMRI with Independent Component Analysis (ICA), Institute of Biophysics and Biomedical Engineering (IBEB), Faculty of Sciences, University of Lisbon.

 

Five year program (BSc + MSc) in Biomedical Engineering and Biophysics (Lisbon University):

MR Elastography: Design and Implementation of a Clinical Tool (MSc. Thesis), Wolfson Brain Imaging Centre, University of Cambridge.

Optimization and validation of Brain State Classification in Vegetative State Patients (BSc. Thesis), Wolfson Brain Imaging Centre, University of Cambridge.

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Show abstracts

Articles (2):

Pavlova MA, Erb M, Hagberg GE, Loureiro J, Sokolov AN and Scheffler K (July-2017) "Wrong Way Up": Temporal and Spatial Dynamics of the Networks for Body Motion Processing at 9.4 T Cerebral Cortex Epub ahead.
Loureiro JR, Hagberg GE, Ethofer T, Erb M, Bause J, Ehses P, Scheffler K and Himmelbach M (January-2017) Depth-dependence of visual signals in the human superior colliculus at 9.4 T Human Brain Mapping 38(1) 574–587.

Posters (4):

Loureiro J, Hagberg G, Tuzzi E, Pohmann R, Schickardt Z, Himmelbach M, Ethofer T, Valverde M, Grodd W and Scheffler K (April-24-2017): Biological underpinnings of different MR contrasts in the human midbrain using quantitative structural MR imaging at 9.4T: Validation with 14T ex-vivo measurements and PLI, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Pavlova M, Erb M, Hagberg G, Loureiro J and Scheffler K (June-29-2016): Body motion presented upside-down: Human ultra-high field 9.4T fMRI, 22nd Annual Meeting of the Organization for Human Brain Mapping (OHBM 2016), Geneva, Switzerland.
Martin P, Hagberg G, Loureiro J, Bause J, Erb M, Lerche H, Scheffler K and Focke N (January-15-2016): Strukturelle Hochfeld-MRT-Bildgebung bei Epilepsie, Forschungskolloquium 2016 der Medizinischen Fakultät, Tübingen, Germany.
Loureiro JRA, Hagberg G, Ethofer T, Erb M, Scheffler K and Himmelbach M (October-19-2015): Depth-dependence of visual signals in the human superior colliculus: Comparison between 3T and 9.4T, 45th Annual Meeting of the Society for Neuroscience (Neuroscience 2015), Chicago, IL, USA.

Talks (7):

Tuzzi E, Hagberg G, Balla D, Loureiro J, Neumann M, Laske C, Pohmann R and Valverde M (April-27-2017) Abstract Talk: In-vivo and ex-vivo R2* and Quantitative Susceptibility Mapping in Alzheimer’s Disease at Ultra-High Magnetic Field compared to Histology, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA 677-678.
Loureiro J (December-9-2016) Invited Lecture: Structural and Functional Imaging of the Human Superior Colliculus at 9.4T, University of Westminster: CAMRI Seminar Series, London, UK.
Martin P, Hagberg G, Loureiro J, Bause J, Lerche H, Focke N and Scheffler K (October-1-2016) Abstract Talk: Can 9.4 T MRI improve lesion visualization in epilepsy patients?, 33rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2016), Wien, Austria, Magnetic Resonance Materials in Physics, Biology and Medicine, 29(Supplement 1) S347-S348.
Loureiro J, Hagberg G, Tuzzi E, Himmelbach M, Ethofer T, Grodd W, Martin P, Valverde M, Pohmann R and Scheffler K (October-1-2016) Abstract Talk: In-vivo ultra-high resolution structural imaging of the human superior colliculus at 9.4T: validation with ex vivo measurements at 9.4T and 14T, 33rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2016), Wien, Austria, Magnetic Resonance Materials in Physics, Biology and Medicine, 29(Supplement 1) S376-S377.
Tuzzi E, Hagberg G, Balla DZ, Loureiro J, Neumann M, Laske C, Pohmann R, Valverde M and Scheffler K (September-30-2016) Abstract Talk: Ex-vivo and in-vivo ultra-High-Field R2* and QSM microimaging in Alzheimer’s disease, 33rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2016), Wien, Austria, Magnetic Resonance Materials in Physics, Biology and Medicine, 29(Supplement 1) S144-S145.
Alves Loureiro J, Hagberg G, Ethofer T, Erb M, Scheffler K and Himmelbach M (May-11-2016) Abstract Talk: Depth-Dependence of Visual Signals in the Human Superior Colliculus at 9.4T: Comparison with 3T, 24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2016), Singapore(0635).
Loureiro JA, Hagberg GE, Ethofer T, Erb M and Scheffler K (October-2015) Abstract Talk: Depth-Dependence of Visual Signals in the Human Superior Colliculus at 9.4T, 32nd Annual Scientific Meeting ESMRMB 2015, Edinburgh, UK, Magnetic Resonance Materials in Physics, Biology and Medicine, 28(1 Supplement) S246-S247.

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Last updated: Monday, 22.05.2017