Contact

Priv.-Doz. Dr. Goran Angelovski

Address: Max-Planck-Ring 11
72076 Tübingen
Room number: 3.A.03
Phone: +49 7071 601 916
Fax: +49 7071 601 919
E-Mail: goran.angelovski

 

Picture of Angelovski, Goran, Priv.-Doz. Dr.

Goran Angelovski

Position: Research Group Leader  Unit: Alumni Logothetis Angelovski

The undergoing research in my group is concentrated on the development of smart (dynamic) and target-specific (anatomical) contrast agents.

 

Interaction of the smart agent with ions and molecules involved in the neural signaling should alter its magnetic properties and would permit the translation of the MR signal and visualization of the neural activation. Development of the successful smart functional marker would lead to the introduction of novel type of functional MRI method.

 

Target-specific contrast agents possess a ligand which specifically binds to the receptor, e.g. genetically engineered protein expressed on the surface of targeted neuronal cells. Selective targeting of neuronal groups may permit the structure-specific monitoring of functional changes with high resolution MRI.

 

Our main interests are:

  • synthesis of MRI contrast agents; employment of novel synthetic routes in the functionalization and derivatization of macrocyclic carriers for paramagnetic metals.
  • investigation of coordination and physicochemical aspects responsible for the events underlying the change of MR signal.
  • development of methods for in vitro and in vivo characterization of novel probes.

 

 

Recent publications:

 

”Coordination Properties of GdDO3A-based Model Compounds of Bioresponsive MRI Contrast Agents.”

S. Gündüz, S. Vibhute, R. Botar, F. Kalman, I. Tóth, G. Tircsó, M. Regueiro-Figueroa, D. Esteban-Gómez, C. Platas-Iglesias, G. Angelovski. Inorg. Chem. 2018, 57, 5973-5986.

 

”QUESP and QUEST Revisited – Fast and Accurate Quantitative CEST Experiments”

M. Zaiss, G. Angelovski, E. Demetriou, M. T. McMahon, X. Golay, K. Scheffler.  Magn. Res. Med. 2018, 79, 1708-1721.

 

“Toward Inert Paramagnetic Ni(II)-Based Chemical Exchange Saturation Transfer MRI Agents”

L. Caneda-Martínez, L. Valencia, I. Fernández-Pérez, M. Regueiro-Figueroa, G. Angelovski, I. Brandariz, D. Esteban-Gómez, C. Platas-Iglesias. Dalton Trans. 2017, 46, 15095-15106.

 

”Heading Toward Macromolecular and Nanosized Bioresponsive MRI Probes for Successful Functional Imaging”

G. Angelovski. Acc. Chem. Res. 2017, 50, 2215-2224.

 

”Spectrally Undiscerned Isomers Might Lead to Erroneous Determination of Water Exchange Rates of paraCEST Eu(III) Agents”

N. Cakić, B. Tickner, M. Zaiss, D. Esteban-Gómez, C. Platas-Iglesias, G. Angelovski.  Inorg. Chem. 2017, 56, 7737-7745.



1993 – 2000

Chemistry studies, University of Belgrade, Serbia

2000

Diploma in Chemistry, University of Belgrade, Serbia

Diploma thesis. Supervisor: Prof. Dr. Bogdan A. Šolaja. Theme: “Synthesis of Tetraoxane Derivatives of Cholic Acid”

2000 – 2004

PhD studies in Organic Chemistry, University of Dortmund.

Supervisor: Prof. Dr. Peter Eilbracht. Theme: “Synthesis of Azamacrocycles via Sequential Hydroformylation / Reductive Amination and Their Application as Fluorescent Dyes”

2004

PhD in Organic Chemistry, University of Dortmund

2005 – 2013

Research scientist and project leader at the Max Planck Institute for Biological Cybernetics, Department for Physiology of Cognitive Processes. Director: Prof. Dr. Nikos K. Logothetis

2012

Venia legendi (Habilitation) in Organic Chemistry, Faculty of Natural Sciences, University of Tübingen. Habilitation thesis: "Synthesis and Characterization of Lanthanide-based Macrocyclic Complexes for Functional and Dual-modal Imaging."

2014 – Research group leader at the Max Planck Institute for Biological Cybernetics, Research group MR Neuroimaging Agents




Grants




2001 – 2004

DAAD PhD fellowship

2009 – 2011

DFG project grant (Design, synthesis and evaluation of smart probes for MRI)

2017 – 2019

DFG project grant (Multimeric and nanoscale bioresponsive probes for functional MRI)


Memberships




German Chemical Society (GDCh)

American Chemical Society (ACS)

Serbian Chemical Society

European Society for Molecular Imaging (ESMI)

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Show abstracts

Posters (25):

Garello F, Vibhute S, Gündüz S, Logothetis NK, Angelovski G and Terreno E (June-3-2015): Improved liposomes-based Ca(II) responsive MRI contrast agents, 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.
Garello F, Vibhute S, Gündüz S, Maier ME, Logothetis NK and Angelovski G (March-20-2015): Improved liposomes-based Ca(II) responsive MRI contrast agents, 10th Annual Meeting of the European Society for Molecular Imaging (EMIM 2015), Tübingen, Germany.
Gündüz S, Power A, Logothetis NK and Angelovski G (April-2014): Synthesis of High Affinity Agents for Targeted MR Neuroimaging, COST Action CM1006: European f-Element Chemistry: EUFEN 3, Nürnberg, Germany.
Gündüz S, Power A, Logothetis NK and Angelovski G (September-3-2013): Synthesis of High Affinity Contrast Agents for Targeted MR Neuroimaging, COST TD1004 Action: Theranostics Imaging and Therapy: An Action to Develop Novel Nanosized Systems for Imaging: Guided Drug Delivery, Athens, Greece.
Jankowska K, Maier ME, Logothetis NK and Angelovski G (December-2012): A novel approach towards Ca2+-responsive MRI probes, Fifth Annual World Molecular Imaging Congress (WMIC 2012), Dublin, Ireland, Molecular Imaging and Biology, 14(Supplement 2) S1234.
Angelovski G, Gottschalk S, Andjus P, Milosevic M and Logothetis NK (December-2012): Characterization of a Calcium-responsive MR-Agent in Cellular Model Systems, Fifth Annual World Molecular Imaging Congress (WMIC 2012), Dublin, Ireland, Molecular Imaging and Biology, 14(Supplement 2) S1663.
Hagberg GE, Mamedov I, Power A, Beyerlein M, Merkle H, Angelovski G and Logothetis NK (May-9-2012): Diffusion in the extra-cellular space of the rat cerebral cortex probed by MRI and direct infusion of contrast agents, 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia.
Placidi M, Engelmann J, Logothetis NK and Angelovski G (February-2012): Aryl Phosphonate-appended macrocyclic lanthanide complexes for application in bimodal imaging, 2011 World Molecular Imaging Congress (WMIC 2011), San Diego, CA, USA, Molecular Imaging and Biology, 14(Supplement 1) S92.
Oukhatar F, Angelovski G, Logothetis NK and Toth E (February-2012): MRI Responsive Contrast Agents: Towards Sensing and Imaging of Neurotransmitters, 2011 World Molecular Imaging Congress (WMIC 2011), San Diego, CA, USA, Molecular Imaging and Biology, 14(Supplement 1) S58.
Angelovski G, Mamdeov I, Engelmann J, Gottschalk S, Balla DZ, Pohmann R and Logothetis NK (November-2010): The Use of Gadolinium-based Contrast Agents for Molecular and Cellular MRI: Quantitative Considerations, 2010 World Molecular Imaging Congress (WMIC), Kyoto, Japan, Molecular Imaging and Biology, 12(Supplement 2) S768.
Mamedov I, Parac-Vogt T, Logothetis NK and Angelovski G (November-2010): Title Dinuclear Heterometallic Lanthanide Complexes Exhibiting MRI and Luminescence Response, 2010 World Molecular Imaging Congress (WMIC), Kyoto, Japan, Molecular Imaging and Biology, 12(Supplement 2) S782.
Mamedov I, Henig J, Angelovski G, Tóth É, Logothetis NK and Mayer HA (February-2010): Unusual Calcium Sensitivity of Aminobis(methylenephosphonate)-Containing MRI Contrast Agents, 2009 World Molecular Imaging Congress (WMIC), Montréal, Canada, Molecular Imaging and Biology, 12(Supplement 1) S40.
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Angelovski G, Chauvin T, Fousková P, Mamedov I, Canals S, Pohmann R, Tóth É and Logothetis NK (October-2009): Smart Calcium-sensitive MRI Agents, 442. Wilhelm und Else Heraeus-Seminar "Molecular Imaging", Bad Honnef, Germany.
Mamedov I, Táborský P, Lubal P, Laurent S, Vander Elst L, Mayer HA, Logothetis NK and Angelovski G (April-2009): Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-based Propylphosphonates, COST Chemistry D38 Annual Workshop: Metal-Based Systems for Molecular Imaging Applications, Warsaw, Poland.
Dhingra K, Maier ME, Beyerlein M, Angelovski G and Logothetis NK (September-2008): Novel Calcium Sensitive MRI Contrast Agent: A Potential Agent for in vivo testing, 2008 World Molecular Imaging Congress (WMIC), Nice, France.
Angelovski G, Fousková P, Mamedov I, Canals S, Tóth É and Logothetis NK (September-2008): Smart MRI Agents Sensing Extracellular Calcium Fluctuations, 2008 World Molecular Imaging Congress (WMIC), Nice, France.
Mamedov I, Angelovski G, Henig J, Mayer HA and Logothetis NK (September-2007): Azamacrocyclic Ca2+ Sensitive Contrast Agents for MR Imaging, AMI/SMI Joint Molecular Imaging Conference 2007, Providence, RI, USA.
pdf
Dhingra K, Fousková P, Angelovski G, Meier ME, Logothetis NK and Tóth É (September-2007): Synthesis and Calcium Dependent Relaxation Studies of new Bismacrocyclic Ligands, AMI/SMI Joint Molecular Imaging Conference 2007, Providence, RI, USA.
Mishra A, Fousková P, Balogh E, Angelovski G, Logothetis NK and Tóth É (September-2007): Synthesis and Relaxation Properties of Three Novel Bis-macrocycles: Attempt towards Calcium Sensitive MRI Contrast Agents, AMI/SMI Joint Molecular Imaging Conference 2007, Providence, RI, USA.
pdf
Angelovski G, Costisella B, Kolaric B, Engelhard M and Eilbracht P (2004): A Piperazine Containing Azamacrocyclic Fluorecent Sensor for Metals, 4th International Conference of the Chemical Societies of the South-East European Countries, Belgrade, Serbia and Montenegro.
Angelovski G, Keränen MD, Kolaric B, Engelhard M and Eilbracht P (2004): Azamacrocyclic Fluorescent Dyes and Sensors Synthesized via Sequential Rhodium-catalyzed Regioselective Hydroformylation and Reductive Amination, ORCHEM 2004, Bad Nauheim, Germany.
Angelovski G, Koc F and Eilbracht P (2002): Synthesis of Macroheterocyclic and Dendrimeric Polyamines via Rhodium Catalyzed Tandem Hydroformylation / Reductive Amination, ORCHEM 2002, Bad Nauheim, Germany.

Theses (1):

Angelovski G: Synthesis of Azamacrocycles via Sequential Hydroformylation / Reductive Amination and Their Application as Fluorescent Dyes, Universität Dortmund, Dortmund, (2004). PhD thesis

Popular Scientific Articles (1):

Angelovski G: Schlaue Kontrastmittel für die funktionelle Magnetresonanztomografie - Forschungsbericht 2010 Max-Planck-Institut für biologische Kybernetik, Jahrbuch der Max-Planck-Gesellschaft 2010.

Talks (23):

Angelovski G (June-15-2018) Invited Lecture: Exploiting Chemistry Probes for Molecular fMRI, University of York: Department of Chemistry, Heslington, UK.
Angelovski G (November-27-2017) Invited Lecture: Design and characterization of molecular sensors for functional MRI applications, XXXII Convegno Nuovi Orientamenti Sintesi Organica, Milano, Italy.
Angelovski G (July-13-2017) Invited Lecture: Bioresponsive Nanosized Probes for Functional MRI Applications, CIC biomaGUNE: Center for Cooperative Research in Biomaterials, San Sebastián, Spain.
Angelovski G (July-4-2016) Invited Lecture: Bioresponsive MRI Agents: Insights from Coordination Chemistry, 42nd International Conference on Coordination Chemistry (ICCC 2016), Brest, France 331.
Angelovski G (June-13-2016) Invited Lecture: Bioresponsive contrast agents for functional MRI: From small to nanosized molecular probes, Munich Symposium on Molecular Devices, Neurons, Circuits & Brains, München, Germany.
Angelovski G (December-8-2015) Invited Lecture: Bioresponsive Nano-sized Contrast Agents for Functional MRI, Conference on Medicinal Flavor of Metal Complexes: Diagnostic and Therapeutic Applications, Orléans, France.
Angelovski G (September-24-2015) Invited Lecture: Bioresponsive Nano-sized Probes for Functional MRI Applications, 24. Nachwuchswissenschaftler-Symposium Bioorganische Chemie (BioOrganik 2015), Hamburg, Germany.
Angelovski G (September-10-2015) Invited Lecture: Bioresponsive nano-sized probes for functional MRI applications, Final Annual Meeting COST Action TD1004: Theranostics Imaging and Therapy: An Action to Develop Novel Nanosized Systems for Imaging-Guided Drug Delivery, Beograd, Serbia.
Angelovski G (March-18-2015) Abstract Talk: Nanosized Calcium-Responsive MRI Contrast Agents, 10th Annual Meeting of the European Society for Molecular Imaging (EMIM 2015), Tübingen, Germany(113).
Angelovski G (May-8-2014) Invited Lecture: Towards the Visualization of Biological Processes with Responsive MRI Contrast Agents, Christian-Albrechts-Universität: GDCh-Kolloquium, Kiel, Germany.
Angelovski G (April-15-2014) Abstract Talk: Towards the Visualization of Biological Processes Using Responsive MRI Contrast Agents, COST Action CM1006: European f-Element Chemistry: EUFEN 3, Nürnberg, Germany 39.
Angelovski G (March-20-2014) Abstract Talk: Dual-frequency MRI contrast agents for visualization of biological processes, 247th ACS National Meeting and Exposition: Chemistry and Materials for Energy, Dallas, TX, USA.
Angelovski G (September-25-2013) Invited Lecture: Dual-Frequency Contrast Agents for 1H/19F MRI, 22. Nachwuchswissenschaftler-Symposium Bioorganische Chemie (BioOrganik 2013), Münster, Germany.
Vibhute SM, Maier ME, Logothetis NK and Angelovski G (September-3-2013) Abstract Talk: Development of Ca2+ Responsive Contrast Agents for fMRI, COST TD1004 Action: Theranostics Imaging and Therapy: An Action to Develop Novel Nanosized Systems for Imaging: Guided Drug Delivery, Athens, Greece(O33) 43.
Angelovski G (June-28-2013) Invited Lecture: Visualization of biological processes using responsive MRI contrast agents, 8th International Conference of the Chemical Societies of the South-East European Countries (ICOSECS 2013), Beograd, Serbia 7.
Angelovski G (November-3-2012) Invited Lecture: Development of Dynamic and Target-specific MRI Probes, 21. Nachwuchswissenschaftler-Symposium Bioorganische Chemie (BioOrganik 2012), Rostock, Germany.
Angelovski G (October-30-2012) Invited Lecture: Dynamic and target-specific MRI probes for neuroimaging, COST Action TD1004 Annual Meeting: Theranostics Imaging and Therapy: An Action to Develop Novel Nanosized Systems for Imaging-Guided Drug Delivery, London, UK.
Angelovski G (November-2011): Development of dynamic and target-specific MRI probes for neuroimaging, Symposium on MRI Probes for Molecular Imaging: From Design to Application, Tübingen, Germany.
Mamedov I, Henig J, Angelovski G, Fousková P, Tóth É, Logothetis NK and Mayer HA (August-25-2009) Abstract Talk: Unusual Calcium Sensitivity of Aminobis(methylenephosphonate)-Containing MRI Contrast Agents, 7th International Conference on f-Elements (ICfE 7) incorporating XXII. Tage der Seltenen Erden Terrae Rarae 2009, Köln, Germany O06-3.
Angelovski G (September-19-2008) Invited Lecture: Calcium-sensitive, Gd-based contrast agents for MRI: Physiology of Cognitive Processes, Joint meeting of the Working Groups 1 and 6 of the COST D-38 Action, Dublin, Ireland.
Angelovski G (August-21-2008) Abstract Talk: Ion-sensitive Gd(III)-chelates as "smart" MRI contrast agents, 236th ACS National Meeting & Exposition, Philadelphia, PA,, USA(ANYL 361).
Mishra A, Mamedov I, Pfeuffer J, Angelovski G, Laurent S, van der Elst L, Müller R, Lubal P, Logothetis NK and Mayer H (June-2006) Abstract Talk: DO3A-Based mono(alkylphosphonate) complexes as potential pH-sensitive contrast agents for MR Imaging, 10th Bi-Annual Conference of the European Magnetic Resonance Forum (EMRF 2006), Vilnius, Lithuania.
Angelovski G, Kolaric B, Engelhard M and Eilbracht P (July-2004) Invited Lecture: A Piperazine-Containing Azamacrocyclic Fluorescent Sensor for Metals, 4th International Conference of the Chemical Societies of the South-East European Countries on Chemical Sciences in Changing Times: Visions, Challenges and Solutions (ICOSECS 2004), Beograd, Serbia and Monenegro 29.
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Last updated: Monday, 22.05.2017