Event Calendar:

October 2014

Mo Tu We Th Fr Sa Su
40 29 30 01 02 03 04 05
41 06 07 08 09 10 11 12
42 13 14 15 16 17 18 19
43 20 21 22 23 24 25 26
44 27 28 29 30 31 01 02

» All Events

Contact

Priv.-Doz. Dr. Goran Angelovski

Address: Spemannstr. 41
72076 Tübingen
Room number: 3.A.03
Phone: +49 7071 601 916
Fax: +49 7071 601 919
E-Mail: goran.angelovski

 

Picture of Angelovski, Goran, Priv.-Doz. Dr.

Goran Angelovski

Position: Research Group Leader  Unit: Alumni Logothetis Angelovski

The undergoing research in my group is concentrated on the development of smart (dynamic) and target-specific (anatomical) contrast agents.

 

Interaction of the smart agent with ions and molecules involved in the neural signaling should alter its magnetic properties and would permit the translation of the MR signal and visualization of the neural activation. Development of the successful smart functional marker would lead to the introduction of novel type of functional MRI method.

 

Target-specific contrast agents possess a ligand which specifically binds to the receptor, e.g. genetically engineered protein expressed on the surface of targeted neuronal cells. Selective targeting of neuronal groups may permit the structure-specific monitoring of functional changes with high resolution MRI.

 

Our main interests are:

  • synthesis of MRI contrast agents; employment of novel synthetic routes in the functionalization and derivatization of macrocyclic carriers for paramagnetic metals.
  • investigation of coordination and physicochemical aspects responsible for the events underlying the change of MR signal.
  • development of methods for in vitro and in vivo characterization of novel probes.

 

 

Recent publications:

 

 

“Dual-frequency Calcium-Responsive MRI Agents”

P. Kadjane, C. Platas-Iglesias, P. Boehm-Sturm, V. Truffault, G. E. Hagberg, M. Hoehn, N. K. Logothetis, G. Angelovski, Chem. Eur. J. 2014, 20, 7351-7362.

 

“Investigation of a Calcium-Responsive Contrast Agent in Cellular Model Systems: Feasibility for Use as a Smart Molecular Probe in Functional MRI”

G. Angelovski, S. Gottschalk, M. Milošević, J. Engelmann, G. E. Hagberg, P. Kadjane, P. Andjus, N. K. Logothetis, ACS Chem. Neurosci. 2014, 5, 360-369.

 

“Diffusion properties of conventional and calcium-sensitive MRI contrast agents in the rat cerebral cortex”

G. E. Hagberg, I. Mamedov, A. Power, M. Beyerlein, H. Merkle, V. G. Kiselev, K. Dhingra, V. Kubìček, G. Angelovski, N. K. Logothetis, Contrast Media Mol. Imaging 2014, 9, 71–82.

 

“Aryl-phosphonate lanthanide complexes and their fluorinated derivatives: investigation of their unusual relaxometric behaviour and potential application as dual frequency 1H/19F MRI probes”

M. P. Placidi, M. Botta, F. K. Kálmán, G. E. Hagberg, Z. Baranyai, A. Krenzer, A. K. Rogerson, I. Tóth, N. K. Logothetis, G. Angelovski, Chem. Eur. J. 2013, 19, 11644-11660.

 

"Synthesis and Characterization of pH-sensitive, Biotinylated MRI Contrast Agents and Their Conjugates with Avidin"

S. M. Vibhute, J. Engelmann, T. Verbić, M. E. Maier, N. K. Logothetis, G. Angelovski, Org. Biomol. Chem. 2013, 11, 1294-1305.

1993 – 2000

Chemistry studies, University of Belgrade, Serbia

2000

Diploma in Chemistry, University of Belgrade, Serbia

Diploma thesis. Supervisor: Prof. Dr. Bogdan A. Šolaja. Theme: “Synthesis of Tetraoxane Derivatives of Cholic Acid”

2000 – 2004

PhD studies in Organic Chemistry, University of Dortmund.

Supervisor: Prof. Dr. Peter Eilbracht. Theme: “Synthesis of Azamacrocycles via Sequential Hydroformylation / Reductive Amination and Their Application as Fluorescent Dyes”

2004

PhD in Organic Chemistry, University of Dortmund

2005 – 2013

Research scientist and project leader at the Max Planck Institute for Biological Cybernetics, Department for Physiology of Cognitive Processes. Director: Prof. Dr. Nikos K. Logothetis

2012

Venia legendi (Habilitation) in Organic Chemistry, Faculty of Natural Sciences, University of Tübingen. Habilitation thesis: "Synthesis and Characterization of Lanthanide-based Macrocyclic Complexes for Functional and Dual-modal Imaging."

2014 – Research group leader at the Max Planck Institute for Biological Cybernetics, Research group MR Neuroimaging Agents

Grants

2001 – 2004

DAAD PhD fellowship

2009 – 2011

DFG project grant

Memberships

German Chemical Society (GDCh)

American Chemical Society (ACS)

Serbian Chemical Society

European Society for Molecular Imaging (ESMI)

Preferences: 
References per page: Year: Medium:

  
Show abstracts

Articles (27):

Kadjane P Person, Platas-Iglesias C , Boehm-Sturm P , Truffault V , Hagberg GE Person, Hoehn M , Logothetis NK Person and Angelovski G Person (June-2014) Dual-Frequency Calcium-Responsive MRI Agents Chemistry - A European Journal 20(24) 7351–7362.
Angelovski G Person, Gottschalk S Person, Milošević M , Engelmann J Person, Hagberg GE Person, Kadjane P Person, Andjus P and Logothetis NK Person (May-2014) Investigation of a Calcium-Responsive Contrast Agent in Cellular Model Systems: Feasibility for Use as a Smart Molecular Probe in Functional MRI ACS Chemical Neuroscience 5(5) 360–369.
Hagberg G Person, Mamedov I Person, Power A Person, Beyerlein M Person, Merkle H Person, Kiselev VG , Dhingra K Person, Kubìček V , Angelovski G Person and Logothetis NK Person (January-2014) Diffusion properties of conventional and calcium-sensitive MRI contrast agents in the rat cerebral cortex Contrast Media & Molecular Imaging 9(1) 71–82.
Placidi MP Person, Botta M , Kálmán FK , Hagberg GE Person, Baranyai Z , Krenzer A , Rogerson AK , Tóth I , Logothetis NK Person and Angelovski G Person (August-2013) Aryl-Phosphonate Lanthanide Complexes and Their Fluorinated Derivatives: Investigation of Their Unusual Relaxometric Behavior and Potential Application as Dual Frequency 1H/19F MRI Probes Chemistry - A European Journal 19(35) 11644–11660.
Vibhute SM Person, Engelmann J Person, Verbić T , Maier ME , Logothetis NK Person and Angelovski G Person (February-2013) Synthesis and characterization of pH-sensitive, biotinylated MRI contrast agents and their conjugates with avidin Organic & Biomolecular Chemistry 11(8) 1294-1305.
Placidi MP Person, Engelmann J Person, Natrajan LS , Logothetis NK Person and Angelovski G Person (September-2011) An aryl-phosphonate appended macrocyclic platform for lanthanide based bimodal imaging agents Chemical Communications 47(41) 11534-11536.
Henig J , Mamedov I Person, Fousková P , Toth E , Logothetis NK Person, Angelovski G Person and Meyer HA (July-2011) Influence of Calcium-Induced Aggregation on the Sensitivity of Aminobis(methylenephosphonate)-Containing Potential MRI Contrast Agents Inorganic Chemistry 50(14) 6472–6481.
Mamdedov I Person, Logothetis NK Person and Angelovski G Person (July-2011) Structure-related variable responses of calcium sensitive MRI probes Organic & Biomolecular Chemistry 9(16) 5816-5824.
Angelovski G Person and Mamedov I Person (May-2011) Cation-Responsive MRI Contrast Agents Based on Gadolinium(III) Current Inorganic Chemistry 1(1) 76-90.
Kadjane P Person, Logothetis NK Person and Angelovski G Person (April-2011) A straightforward and convenient pathway for the synthesis of functional bismacrocyclic ligands Tetrahedron Letters 52(14) 1619-1622.
Angelovski G Person, Chauvin T , Pohmann R Person, Logothetis NK Person and Toth E (February-2011) Calcium-responsive paramagnetic CEST agents Bioorganic and Medicinal Chemistry 19(3) 1097-1105.
Mamedov I Person, Canals S Person, Henig J , Beyerlein M Person, Murayama Y Person, Mayer HA , Logothetis NK Person and Angelovski G Person (December-2010) In Vivo Characterization of a Smart MRI Agent That Displays an Inverse Response to Calcium Concentration ACS Chemical Neuroscience 1(12) 819-828.
Mamedov I Person, Parac-Vogt TN , Logothetis NK Person and Angelovski G Person (May-2010) Synthesis and characterization of dinuclear heterometallic lanthanide complexes exhibiting MRI and luminescence response Dalton Transactions 39(24) 5721-5727.
Mamedov I Person, Táborský P , Lubal P , Laurent S , Elst LV , Mayer HA , Logothetis NK Person and Angelovski G Person (August-2009) Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-Based Propylphosphonates European Journal of Inorganic Chemistry 2009(22) 3298-3306.
Angelovski G Person, Fousková P , Mamedov I Person, Canals S Person, Tóth É and Logothetis NK Person (July-2008) Smart Magnetic Resonance Imaging Agents that Sense Extracellular Calcium Fluctuations ChemBioChem 9(11) 1729-1734.
Dhingra K Person, Maier ME , Beyerlein M Person, Angelovski G Person and Logothetis NK Person (June-2008) Synthesis and Characterization of a Smart Contrast Agent Sensitive to Calcium Chemical Communications 29 3444-3446.
Mishra A Person, Fousková P , Angelovski G Person, Balogh E , Mishra AK Person, Logothetis NK Person and Tóth É (April-2008) Facile Synthesis and Relaxation Properties of Novel Bispolyazamacrocyclic Gd3+ Complexes: An Attempt towards Calcium-Sensitive MRI Contrast Agents - Correction Inorganic Chemistry 47(8) 3460.
Mishra A Person, Fousková P , Angelovski G Person, Balogh E , Mishra AK Person, Logothetis NK Person and Tóth É (February-2008) Facile Synthesis and Relaxation Properties of Novel Bis-polyazamacrocyclic Gd3+ Complexes: an Attempt towards Calcium Sensitive MRI Contrast Agents Inorganic Chemistry 47(4) 1370-1381.
Dhingra K Person, Fousková P , Angelovski G Person, Maier ME , Logothetis NK Person and Tóth É (January-2008) Towards extracellular Ca2+ sensing by MRI: synthesis and calcium-dependent 1H and 17O relaxation studies of two novel bismacrocyclic Gd3+ complexes. Journal of Biological Inorganic Chemistry 13(1) 35-46.
Mamedov I Person, Mishra A Person, Angelovski G Person, Mayer HA , L-O , Parker D and Logothetis NK Person (December-2007) Synthesis and Characterization of Lanthanide Complexes of DO3A-Alkylphosphonates Dalton Transactions 45 5260-5267.
Ricken S , Angelovski G Person, Schürmann M , Preut H and Eilbracht P (February-2007) (S)-(–)-2,2‘-Bis(2-methyl­allyl­oxy)-1,1‘-binaphth­yl Acta Crystallographica Section E 63(2) o551-o552.
Angelovski G Person, Keränen MD , Linnepe P , Grudzielanek S and Eilbracht P (July-2006) A Rapid and Reliable Assay for Regioselectivity Using Fluorescence Spectroscopy Advanced Synthesis and Catalysis 348(10-11) 1193-1199.
Opsenica I , Terzic N , Opsenica D , Angelovski G Person, Lehnig M , Eilbracht P , Tinant B , Juranic Z , Smith KS , Yang YS , Diaz DS , Smith PL , Milhous WK , Djokovic D and Solaja BA (June-2006) Tetraoxane Antimalarials and Their Reaction with Fe(II) Journal of Medicinal Chemistry 49(13) 3790-3799.
Angelovski G Person, Keränen MD and Eilbracht P (2005) Fluorescence screening of tartaric acid-derived azamacrocycles synthesized via sequential hydroformylation/reductive amination as potential ligands for asymmetric catalysis Tetrahedron: Asymmetry 16 1919-1926.
Angelovski G Person, Costisella B , Kolaric B , Engelhard M and Eilbracht P (2004) Complexation of Metals with Piperazine-containing Azamacrocyclic Fluorophores J. Org. Chem. 59 5290-5294.
Opsenica D , Angelovski G Person, Pocsfalvi G , Juranic Z , Zizak Z , Kyle D , Milhous WK and Solaja BA (2003) Antimalarial and Antiproliferative Evaluation of Bis-Steroidal Tetraoxanes Bioorg. Med. Chem. 11 2761-2768.
Angelovski G Person and Eilbracht P (2003) Synthesis of hydroquinone-, biphenol-, and binaphthol-containing aza macroheterocycles via regioselective hydroformylation and reductive amination Tetrahedron 59 8265-8274.

Posters (16):

Jankowska K Person, Maier ME , Logothetis NK Person and Angelovski G Person (September-2012): A novel approach towards Ca2+-responsive MRI probes, Fifth Annual World Molecular Imaging Congress (WMIC 2012), Dublin, Ireland.
Angelovski G Person (September-2012): Characterization of a Calcium-responsive MR-Agent in Cellular Model Systems, Fifth Annual World Molecular Imaging Congress (WMIC 2012), Dublin, Ireland.
Hagberg GE Person, Mamedov I Person, Power A Person, Beyerlein M Person, Merkle H Person, Angelovski G Person and Logothetis NK Person (May-9-2012): Diffusion in the extra-cellular space of the rat cerebral cortex probed by MRI and direct infusion of contrast agents, 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia.
Angelovski G Person, Mamdeov I Person, Engelmann J Person, Gottschalk S Person, Balla DZ Person, Pohmann R Person and Logothetis NK Person (September-2010): The Use of Gadolinium-based Contrast Agents for Molecular and Cellular MRI: Quantitative Considerations, 2010 World Molecular Imaging Congress (WMIC), Kyoto, Japan.
Mamedov I Person, Parac-Vogt T , Logothetis NK Person and Angelovski G Person (September-2010): Title Dinuclear Heterometallic Lanthanide Complexes Exhibiting MRI and Luminescence Response, 2010 World Molecular Imaging Congress (WMIC), Kyoto, Japan.
Angelovski G Person, Chauvin T , Fousková P , Mamedov I Person, Canals S Person, Pohmann R Person, Tóth É and Logothetis NK Person (October-2009): Smart Calcium-sensitive MRI Agents, 442. Wilhelm und Else Heraeus-Seminar "Molecular Imaging", Bad Honnef, Germany.
Mamedov I Person, Henig J , Angelovski G Person, Tóth É , Logothetis NK Person and Mayer HA Person (September-2009): Unusual Calcium Sensitivity of Aminobis(methylenephosphonate)-Containing MRI Contrast Agents, 2009 World Molecular Imaging Congress (WMIC), Montréal, Canada.
pdf
Mamedov I Person, Táborský P , Lubal P , Laurent S , Elst LV , Logothetis N Person and Angelovski G Person (April-2009): Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-based Propylphosphonates, CMST COST Action D38: Metal-Based Systems for Molecular Imaging Applications, Tübingen, Germany.
pdf
Dhingra K Person, Maier ME , Beyerlein M Person, Angelovski G Person and Logothetis NK Person (September-2008): Novel Calcium Sensitive MRI Contrast Agent: A Potential Agent for in vivo testing, 2008 World Molecular Imaging Congress (WMIC), Nice, France.
Angelovski G Person, Fousková P , Mamedov I Person, Canals S Person, Tóth É and Logothetis NK Person (September-2008): Smart MRI Agents Sensing Extracellular Calcium Fluctuations, 2008 World Molecular Imaging Congress (WMIC), Nice, France.
Mamedov I Person, Angelovski G Person, Henig J , Mayer HA and Logothetis NK Person (September-2007): Azamacrocyclic Ca2+ Sensitive Contrast Agents for MR Imaging, AMI/SMI Joint Molecular Imaging Conference 2007, Providence, RI, USA.
pdf
Dhingra K Person, Fousková P , Angelovski G Person, Meier ME , Logothetis NK Person and Tóth É (September-2007): Synthesis and Calcium Dependent Relaxation Studies of new Bismacrocyclic Ligands, AMI/SMI Joint Molecular Imaging Conference 2007, Providence, RI, USA.
Mishra A Person, Fousková P , Balogh E , Angelovski G Person, Logothetis NK Person and Tóth É (September-2007): Synthesis and Relaxation Properties of Three Novel Bis-macrocycles: Attempt towards Calcium Sensitive MRI Contrast Agents, AMI/SMI Joint Molecular Imaging Conference 2007, Providence, RI, USA.
pdf
Angelovski G Person, Costisella B , Kolaric B , Engelhard M and Eilbracht P (2004): A Piperazine Containing Azamacrocyclic Fluorecent Sensor for Metals, 4th International Conference of the Chemical Societies of the South-East European Countries, Belgrade, Serbia and Montenegro.
Angelovski G Person, Keränen MD , Kolaric B , Engelhard M and Eilbracht P (2004): Azamacrocyclic Fluorescent Dyes and Sensors Synthesized via Sequential Rhodium-catalyzed Regioselective Hydroformylation and Reductive Amination, ORCHEM 2004, Bad Nauheim, Germany.
Angelovski G Person, Koc F and Eilbracht P (2002): Synthesis of Macroheterocyclic and Dendrimeric Polyamines via Rhodium Catalyzed Tandem Hydroformylation / Reductive Amination, ORCHEM 2002, Bad Nauheim, Germany.

Theses (1):

Angelovski G Person: Synthesis of Azamacrocycles via Sequential Hydroformylation / Reductive Amination and Their Application as Fluorescent Dyes, Universität Dortmund, Dortmund, (2004). PhD thesis

Talks (4):

Angelovski G Person (November-2011): Development of dynamic and target-specific MRI probes for neuroimaging, Symposium on MRI Probes for Molecular Imaging: From Design to Application, Tübingen, Germany.
Angelovski G Person (August-25-2009): Unusual Calcium Sensitivity of Aminobis(methylenephosphonate)-Containing MRI Contrast Agents, 7th International Conference on f-Elements, Köln, Germany.
Angelovski G Person (August-2008): Ion-sensitive Gd(III)-chelates as "smart" MRI contrast agents, 236th National Meeting & Exposition of the American Chemical Society, Philadelphia, PA,, USA(ANYL 361).
Mishra A Person, Mamedov I Person, Pfeuffer J Person, Angelovski G Person, Laurent S , van der Elst L , Müller R , Lubal P , Logothetis NK Person and Mayer H (June-2006) Abstract Talk: DO3A-Based mono(alkylphosphonate) complexes as potential pH-sensitive contrast agents for MR Imaging, 10th Bi-Annual Conference of the European Magnetic Resonance Forum (EMRF 2006), Vilnius, Lithuania.

Export as:
BibTeX, XML, Pubman, Edoc, RTF
Last updated: Tuesday, 23.09.2014