Contact

Priv.-Doz. Dr. Goran Angelovski

Address: Spemannstr. 41
72076 Tübingen
Room number: 3.A.03
Phone: +49 7071 601 916
Fax: +49 7071 601 919
E-Mail: goran.angelovski

 

Picture of Angelovski, Goran, Priv.-Doz. Dr.

Goran Angelovski

Position: Research Group Leader  Unit: Alumni Logothetis Angelovski

The undergoing research in my group is concentrated on the development of smart (dynamic) and target-specific (anatomical) contrast agents.

 

Interaction of the smart agent with ions and molecules involved in the neural signaling should alter its magnetic properties and would permit the translation of the MR signal and visualization of the neural activation. Development of the successful smart functional marker would lead to the introduction of novel type of functional MRI method.

 

Target-specific contrast agents possess a ligand which specifically binds to the receptor, e.g. genetically engineered protein expressed on the surface of targeted neuronal cells. Selective targeting of neuronal groups may permit the structure-specific monitoring of functional changes with high resolution MRI.

 

Our main interests are:

  • synthesis of MRI contrast agents; employment of novel synthetic routes in the functionalization and derivatization of macrocyclic carriers for paramagnetic metals.
  • investigation of coordination and physicochemical aspects responsible for the events underlying the change of MR signal.
  • development of methods for in vitro and in vivo characterization of novel probes.

 

 

Recent publications:

 

“Gd3+-based Magnetic Resonance Imaging Contrast Agent Responsive to Zn2+

M. Regueiro-Figueroa, S. Gündüz, V. Patinec, N. K. Logothetis, D. Esteban-Gómez, R. Tripier, G. Angelovski, C. Platas-Iglesias. Inorg. Chem. 2015, doi: 10.1021/acs.inorgchem.5b01719.

 

„Ultra-small Nano-platforms as Calcium-Responsive Contrast Agents for Magnetic Resonance Imaging”

A. Moussaron, S. Vibhute, A. Bianchi, S. Gündüz, S. Kotb, L. Sancey, V. Motto-Ros, Y. Crémillieux, F. Lux, N. K. Logothetis, O. Tillement, G. Angelovski, Small 2015, 11, 4900-4909.

 

"Macrocyclic Gd3+ Complexes with Pendant Crown Ethers Designed for Binding Zwitterionic Neurotransmitters"

F. Oukhatar, H. Meudal, C. Landon, N. K. Logothetis, C. Platas-Iglesias, G. Angelovski, É. Tóth, Chem. Eur. J. 2015, 21, 11226-11237.

 

“Synthetic strategies for preparation of cyclen-based MRI contrast agents”

N. Cakić, S. Gündüz, R. Rengarasu, G. Angelovski, Tetrahedron Lett. 2015, 56, 759-765.

 

“MRI sensing of neurotransmitters with a crown-ether appended Gd3+ complex”

F. Oukhatar, S. Même, W. Même, F. Szeremeta, N. K. Logothetis, G. Angelovski, É. Tóth, ACS Chem. Neurosci. 2015, 6, 219-225.

 

“Synthesis and Characterization of a Biotinylated Multivalent Targeted Contrast Agent”

S. Gündüz, A. Power, M. E. Maier, N. K. Logothetis, G. Angelovski, ChemPlusChem 2015, 80, 612-622.

 

“Dendrimeric Calcium-responsive MRI Contrast Agents with Slow in vivo Diffusion”

S. Gündüz, N. Nitta, S. Vibhute, S. Shibata, M. E. Maier, N. K. Logothetis, I. Aoki, G. Angelovski, Chem. Commun. 201551, 2782-2785.

1993 – 2000

Chemistry studies, University of Belgrade, Serbia

2000

Diploma in Chemistry, University of Belgrade, Serbia

Diploma thesis. Supervisor: Prof. Dr. Bogdan A. Šolaja. Theme: “Synthesis of Tetraoxane Derivatives of Cholic Acid”

2000 – 2004

PhD studies in Organic Chemistry, University of Dortmund.

Supervisor: Prof. Dr. Peter Eilbracht. Theme: “Synthesis of Azamacrocycles via Sequential Hydroformylation / Reductive Amination and Their Application as Fluorescent Dyes”

2004

PhD in Organic Chemistry, University of Dortmund

2005 – 2013

Research scientist and project leader at the Max Planck Institute for Biological Cybernetics, Department for Physiology of Cognitive Processes. Director: Prof. Dr. Nikos K. Logothetis

2012

Venia legendi (Habilitation) in Organic Chemistry, Faculty of Natural Sciences, University of Tübingen. Habilitation thesis: "Synthesis and Characterization of Lanthanide-based Macrocyclic Complexes for Functional and Dual-modal Imaging."

2014 – Research group leader at the Max Planck Institute for Biological Cybernetics, Research group MR Neuroimaging Agents

Grants

2001 – 2004

DAAD PhD fellowship

2009 – 2011

DFG project grant

Memberships

German Chemical Society (GDCh)

American Chemical Society (ACS)

Serbian Chemical Society

European Society for Molecular Imaging (ESMI)

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Articles (34):

Regueiro-Figueroa M, Gündüz S, Patinec V, Logothetis NK, Esteban-Gómez D, Tripier R, Angelovski G and Platas-Iglesias C (November-2015) Gd3+-Based Magnetic Resonance Imaging Contrast Agent Responsive to Zn2+ Inorganic Chemistry 54(21) 10342–10350.
Moussaron A, Vibhute S, Bianchi A, Gündüz S, Kolb S, Sancey L, Motto-Ros V, Rizzitelli S, Crémillieux Y, Lux F, Logothetis NK, Tillement O and Angelovski G (October-2015) Ultrasmall Nanoplatforms as Calcium-Responsive Contrast Agents for Magnetic Resonance Imaging Small 11(37) 4900–4909.
Oukhatar F, Meudal H, Landon C, Logothetis NK, Platas-Iglesias C, Angelovski G and Toth E (July-2015) Macrocyclic Gd3+ Complexes with Pendant Crown Ethers Designed for Binding Zwitterionic Neurotransmitters Chemistry - A European Journal 21(31) 11226–11237.
Gündüz S, Power A, Maier ME, Logothetis NK and Angelovski G (March-2015) Synthesis and Characterization of a Biotinylated Multivalent Targeted Contrast Agent ChemPlusChem 80(3) 612–622.
Oukhatar F, Même S, Même W, Szeremeta F, Logothetis NK, Angelovski G and Toth E (February-2015) MRI sensing of neurotransmitters with a crown-ether appended Gd3+ complex ACS Chemical Neuroscience 6(2) 219–225.
Cakić N, Gündüz S, Rengarasu R and Angelovski G (February-2015) Synthetic strategies for preparation of cyclen-based MRI contrast agents Tetrahedron Letters 56(6) 759–765.
Gündüz S, Nitta N, Vibhute SM, Shibata S, Maier ME, Logothetis NK, Aoki I and Angelovski G (January-2015) Dendrimeric Calcium-responsive MRI Contrast Agents with Slow in vivo Diffusion Chemical Communications 51(14) 2782-2785.
Kadjane P, Platas-Iglesias C, Boehm-Sturm P, Truffault V, Hagberg GE, Hoehn M, Logothetis NK and Angelovski G (June-2014) Dual-Frequency Calcium-Responsive MRI Agents Chemistry: A European Journal 20(24) 7351–7362.
Angelovski G, Gottschalk S, Milošević M, Engelmann J, Hagberg GE, Kadjane P, Andjus P and Logothetis NK (May-2014) Investigation of a Calcium-Responsive Contrast Agent in Cellular Model Systems: Feasibility for Use as a Smart Molecular Probe in Functional MRI ACS Chemical Neuroscience 5(5) 360–369.
Hagberg G, Mamedov I, Power A, Beyerlein M, Merkle H, Kiselev VG, Dhingra K, Kubìček V, Angelovski G and Logothetis NK (January-2014) Diffusion properties of conventional and calcium-sensitive MRI contrast agents in the rat cerebral cortex Contrast Media & Molecular Imaging 9(1) 71–82.
Placidi MP, Botta M, Kálmán FK, Hagberg GE, Baranyai Z, Krenzer A, Rogerson AK, Tóth I, Logothetis NK and Angelovski G (August-2013) Aryl-Phosphonate Lanthanide Complexes and Their Fluorinated Derivatives: Investigation of Their Unusual Relaxometric Behavior and Potential Application as Dual Frequency 1H/19F MRI Probes Chemistry - A European Journal 19(35) 11644–11660.
Vibhute SM, Engelmann J, Verbić T, Maier ME, Logothetis NK and Angelovski G (February-2013) Synthesis and characterization of pH-sensitive, biotinylated MRI contrast agents and their conjugates with avidin Organic & Biomolecular Chemistry 11(8) 1294-1305.
Placidi MP, Engelmann J, Natrajan LS, Logothetis NK and Angelovski G (September-2011) An aryl-phosphonate appended macrocyclic platform for lanthanide based bimodal imaging agents Chemical Communications 47(41) 11534-11536.
Henig J, Mamedov I, Fousková P, Toth E, Logothetis NK, Angelovski G and Meyer HA (July-2011) Influence of Calcium-Induced Aggregation on the Sensitivity of Aminobis(methylenephosphonate)-Containing Potential MRI Contrast Agents Inorganic Chemistry 50(14) 6472–6481.
Mamdedov I, Logothetis NK and Angelovski G (July-2011) Structure-related variable responses of calcium sensitive MRI probes Organic & Biomolecular Chemistry 9(16) 5816-5824.
Angelovski G and Mamedov I (May-2011) Cation-Responsive MRI Contrast Agents Based on Gadolinium(III) Current Inorganic Chemistry 1(1) 76-90.
Kadjane P, Logothetis NK and Angelovski G (April-2011) A straightforward and convenient pathway for the synthesis of functional bismacrocyclic ligands Tetrahedron Letters 52(14) 1619-1622.
Angelovski G, Chauvin T, Pohmann R, Logothetis NK and Toth E (February-2011) Calcium-responsive paramagnetic CEST agents Bioorganic and Medicinal Chemistry 19(3) 1097-1105.
Mamedov I, Canals S, Henig J, Beyerlein M, Murayama Y, Mayer HA, Logothetis NK and Angelovski G (December-2010) In Vivo Characterization of a Smart MRI Agent That Displays an Inverse Response to Calcium Concentration ACS Chemical Neuroscience 1(12) 819-828.
Mamedov I, Parac-Vogt TN, Logothetis NK and Angelovski G (May-2010) Synthesis and characterization of dinuclear heterometallic lanthanide complexes exhibiting MRI and luminescence response Dalton Transactions 39(24) 5721-5727.
Mamedov I, Táborský P, Lubal P, Laurent S, Elst LV, Mayer HA, Logothetis NK and Angelovski G (August-2009) Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-Based Propylphosphonates European Journal of Inorganic Chemistry 2009(22) 3298-3306.
Angelovski G, Fousková P, Mamedov I, Canals S, Tóth É and Logothetis NK (July-2008) Smart Magnetic Resonance Imaging Agents that Sense Extracellular Calcium Fluctuations ChemBioChem 9(11) 1729-1734.
Dhingra K, Maier ME, Beyerlein M, Angelovski G and Logothetis NK (June-2008) Synthesis and Characterization of a Smart Contrast Agent Sensitive to Calcium Chemical Communications 29 3444-3446.
Mishra A, Fousková P, Angelovski G, Balogh E, Mishra AK, Logothetis NK and Tóth É (April-2008) Facile Synthesis and Relaxation Properties of Novel Bispolyazamacrocyclic Gd3+ Complexes: An Attempt towards Calcium-Sensitive MRI Contrast Agents - Correction Inorganic Chemistry 47(8) 3460.
Mishra A, Fousková P, Angelovski G, Balogh E, Mishra AK, Logothetis NK and Tóth É (February-2008) Facile Synthesis and Relaxation Properties of Novel Bis-polyazamacrocyclic Gd3+ Complexes: an Attempt towards Calcium Sensitive MRI Contrast Agents Inorganic Chemistry 47(4) 1370-1381.
Dhingra K, Fousková P, Angelovski G, Maier ME, Logothetis NK and Tóth É (January-2008) Towards extracellular Ca2+ sensing by MRI: synthesis and calcium-dependent 1H and 17O relaxation studies of two novel bismacrocyclic Gd3+ complexes. Journal of Biological Inorganic Chemistry 13(1) 35-46.
Mamedov I, Mishra A, Angelovski G, Mayer HA, L-O, Parker D and Logothetis NK (December-2007) Synthesis and Characterization of Lanthanide Complexes of DO3A-Alkylphosphonates Dalton Transactions 45 5260-5267.
Ricken S, Angelovski G, Schürmann M, Preut H and Eilbracht P (February-2007) (S)-(–)-2,2‘-Bis(2-methyl­allyl­oxy)-1,1‘-binaphth­yl Acta Crystallographica Section E 63(2) o551-o552.
Angelovski G, Keränen MD, Linnepe P, Grudzielanek S and Eilbracht P (July-2006) A Rapid and Reliable Assay for Regioselectivity Using Fluorescence Spectroscopy Advanced Synthesis and Catalysis 348(10-11) 1193-1199.
Opsenica I, Terzic N, Opsenica D, Angelovski G, Lehnig M, Eilbracht P, Tinant B, Juranic Z, Smith KS, Yang YS, Diaz DS, Smith PL, Milhous WK, Djokovic D and Solaja BA (June-2006) Tetraoxane Antimalarials and Their Reaction with Fe(II) Journal of Medicinal Chemistry 49(13) 3790-3799.
Angelovski G, Keränen MD and Eilbracht P (June-2005) Fluorescence screening of tartaric acid-derived azamacrocycles synthesized via sequential hydroformylation/reductive amination as potential ligands for asymmetric catalysis Tetrahedron: Asymmetry 16(11) 1919-1926.
Angelovski G, Costisella B, Kolaric B, Engelhard M and Eilbracht P (August-2004) Complexation of Metals with Piperazine-containing Azamacrocyclic Fluorophores Journal of Organic Chemistry 69(16) 5290-5294.
Angelovski G and Eilbracht P (October-2003) Synthesis of hydroquinone-, biphenol-, and binaphthol-containing aza macroheterocycles via regioselective hydroformylation and reductive amination Tetrahedron 59(41) 8265-8274.
Opsenica D, Angelovski G, Pocsfalvi G, Juranic Z, Zizak Z, Kyle D, Milhous WK and Solaja BA (July-2003) Antimalarial and Antiproliferative Evaluation of Bis-Steroidal Tetraoxanes Bioorganic & Medicinal Chemistry 11(13) 2761-2768.

Posters (22):

Garello F, Vibhute S, Gündüz S, Logothetis NK, Angelovski G and Terreno E (June-3-2015): Improved liposomes-based Ca(II) responsive MRI contrast agents, 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.
Garello F, Vibhute S, Gündüz S, Maier ME, Logothetis NK and Angelovski G (March-20-2015): Improved liposomes-based Ca(II) responsive MRI contrast agents, 10th Annual Meeting of the European Society for Molecular Imaging (EMIM 2015), Tübingen, Germany.
Gündüz S, Power A, Logothetis NK and Angelovski G (September-3-2013): Synthesis of High Affinity Contrast Agents for Targeted MR Neuroimaging, COST TD1004 Action: Theranostics Imaging and Therapy: An Action to Develop Novel Nanosized Systems for Imaging: Guided Drug Delivery, Athens, Greece.
Jankowska K, Maier ME, Logothetis NK and Angelovski G (November-2012): A novel approach towards Ca2+-responsive MRI probes, Fifth Annual World Molecular Imaging Congress (WMIC 2012), Dublin, Ireland, Molecular Imaging and Biology, 14(2 Supplement) S1234.
Angelovski G, Andjus P and Milosevic M (November-2012): Characterization of a Calcium-responsive MR-Agent in Cellular Model Systems, Fifth Annual World Molecular Imaging Congress (WMIC 2012), Dublin, Ireland, Molecular Imaging and Biology, 14(2 Supplement) S1663.
Hagberg GE, Mamedov I, Power A, Beyerlein M, Merkle H, Angelovski G and Logothetis NK (May-9-2012): Diffusion in the extra-cellular space of the rat cerebral cortex probed by MRI and direct infusion of contrast agents, 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia.
Placidi M, Engelmann J, Logothetis NK and Angelovski G (February-2012): Aryl Phosphonate-appended macrocyclic lanthanide complexes for application in bimodal imaging, 2011 World Molecular Imaging Congress (WMIC 2011), San Diego, CA, USA, Molecular Imaging and Biology, 14(1 Supplement) S92.
Oukhatar F, Angelovski G, Logothetis NK and Toth E (February-2012): MRI Responsive Contrast Agents: Towards Sensing and Imaging of Neurotransmitters, 2011 World Molecular Imaging Congress (WMIC 2011), San Diego, CA, USA, Molecular Imaging and Biology, 14(1 Supplement) S58.
Angelovski G, Mamdeov I, Engelmann J, Gottschalk S, Balla DZ, Pohmann R and Logothetis NK (November-2010): The Use of Gadolinium-based Contrast Agents for Molecular and Cellular MRI: Quantitative Considerations, 2010 World Molecular Imaging Congress (WMIC), Kyoto, Japan, Molecular Imaging and Biology, 12(2 Supplement) S768.
Mamedov I, Parac-Vogt T, Logothetis NK and Angelovski G (November-2010): Title Dinuclear Heterometallic Lanthanide Complexes Exhibiting MRI and Luminescence Response, 2010 World Molecular Imaging Congress (WMIC), Kyoto, Japan, Molecular Imaging and Biology, 12(2 Supplement) S782.
Mamedov I, Henig J, Angelovski G, Tóth É, Logothetis NK and Mayer HA (February-2010): Unusual Calcium Sensitivity of Aminobis(methylenephosphonate)-Containing MRI Contrast Agents, 2009 World Molecular Imaging Congress (WMIC), Montréal, Canada, Molecular Imaging and Biology, 12(1 Supplement) S40.
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Angelovski G, Chauvin T, Fousková P, Mamedov I, Canals S, Pohmann R, Tóth É and Logothetis NK (October-2009): Smart Calcium-sensitive MRI Agents, 442. Wilhelm und Else Heraeus-Seminar "Molecular Imaging", Bad Honnef, Germany.
Mamedov I, Táborský P, Lubal P, Laurent S, Elst LV, Logothetis N and Angelovski G (April-2009): Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-based Propylphosphonates, CMST COST Action D38: Metal-Based Systems for Molecular Imaging Applications, Tübingen, Germany.
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Mamedov I, Táborský P, Lubal P, Laurent S, Vander Elst L, Mayer HA, Logothetis NK and Angelovski G (April-2009): Relaxometric, Thermodynamic and Kinetic Studies of Lanthanide(III) Complexes of DO3A-based Propylphosphonates, COST Action D38 Annual Workshop: Metal-Based Systems for Molecular Imaging Applications, Warsaw, Poland.
Dhingra K, Maier ME, Beyerlein M, Angelovski G and Logothetis NK (September-2008): Novel Calcium Sensitive MRI Contrast Agent: A Potential Agent for in vivo testing, 2008 World Molecular Imaging Congress (WMIC), Nice, France.
Angelovski G, Fousková P, Mamedov I, Canals S, Tóth É and Logothetis NK (September-2008): Smart MRI Agents Sensing Extracellular Calcium Fluctuations, 2008 World Molecular Imaging Congress (WMIC), Nice, France.
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Last updated: Tuesday, 18.11.2014