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Contact

Dr. Damian Wallace

Address: Spemannstr. 41
72076 Tübingen
Fax: +49 7071 601 1720
E-Mail: Damian.Wallace

 

Picture of Wallace, Damian, Dr.

Damian Wallace

Position: Postdoctoral Fellow  Unit: Alumni Kerr

One of the central roles, if not the primary role, of the cortex is to provide an animal with an appropriate behavioural response to the environmental conditions and challenges it encounters.  Current information about the environment can be compared to past experience, mood and motivation taken into account and a behavioural response initiated. A fundamental philosophy of the Kerr group is to allow animal behavior to inform and guide the design of experiments aimed at understanding how the cortex performs is job and how the neuronal circuits central to cortical function operate.We use a combination of imaging techniques and electrophysiology in freely moving and awake head-restrained animals to investigate cortical physiology and function. These techniques include multi-photon imaging of activity in populations of neurons in freely moving rats using a custom-built miniaturized multi-photon microscope, imaging eye movements in freely moving rats using a custom-built miniature ocular videography system, multiphoton-imaging of population activity in head-restrained rats and combined multiphoton imaging and whole-cell patch clamp or juxtasomal extracellular recording. Central to the approach is the design and implementation of behavioural paradigms for investigating the characteristics of neuronal circuit activity during the decision making process. Further, wherever possible we employ experimental designs which allow the animals to move freely and self-determine their interactions with objects and elements in the experimental environment in order to eliminate as many assumptions as possible about their preferred methods of interaction.

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Articles (6):

Wallace DJ Person, Greenberg DS Person, Sawinski J Person, Rulla S Person, Notaro G Person and Kerr JND Person (June-2013) Rats maintain an overhead binocular field at the expense of constant fusion Nature 498(7452) 65–69.
Valverde Salzmann MF Person, Wallace DJ Person, Logothetis NK Person and Schüz A Person (September-2011) Multimodal vessel mapping for precise large area alignment of functional optical imaging data to neuroanatomical preparations in marmosets Journal of Neuroscience Methods 201(1) 159-172.
Mittmann W Person, Wallace DJ Person, Czubayko U Person, Herb JT , Schaefer AT , Looger LL , Denk W and Kerr JND Person (August-2011) Two-photon calcium imaging of evoked activity from L5 somatosensory neurons in vivo Nature Neuroscience 14(8) 1089-1093.
Wallace DJ Person and Kerr JN Person (June-2010) Chasing the cell assembly Current Opinion in Neurobiology 20(3) 296-305.
Sawinski J Person, Wallace DJ Person, Greenberg DS Person, Grossmann S , Denk W and Kerr JND Person (November-2009) Visually evoked activity in cortical cells imaged in freely moving animals Proceedings of the National Academy of Sciences of the United States of America 106(46) 19557-19562.
Wallace DJ Person, Borgloh SMZA , Astori S , Yang Y , Bausen M , Kügler S , Palmer AE , Tsien RY , Sprengel R , Kerr JND Person, Denk W and Hasan MT (August-2008) Single-spike detection in vitro and in vivo with a genetic Ca2+ sensor Nature Methods 5(9) 797-804.

Contributions to books (1):

Greenberg DS Person, Wallace DJ Person and Kerr JND Person: Imaging Neuronal Population Activity in Awake and Anesthetized Rodents, 839-850. In: Imaging in Neuroscience: A Laboratory Manual, (Ed) F. Helmchen, Cold Spring Harbour Laboratory Press, Cold Spring Harbor, NY, USA, (May-2011).

Posters (7):

Sawinski J Person, Greenberg DS Person, Wallace DJ Person and Kerr J Person (October-2012): Combining ocular videography and 2-photon imaging in freely moving rats, 42nd Annual Meeting of the Society for Neuroscience (Neuroscience 2012), New Orleans, LA, USA.
Wallace DJ Person, Sawinski J Person, Greenberg DS Person, Notaro G Person, Rulla S Person and Kerr JND Person (October-2012): Eye movements in rats maintain an overhead binocular field at the expense of binocular fusion, 42nd Annual Meeting of the Society for Neuroscience (Neuroscience 2012), New Orleans, LA, USA.
Greenberg DS Person, Wallace D Person, Sawinski J Person, Notaro G Person, Rulla S Person and Kerr JND Person (October-2012): Optical tracking of head movements, eye movements and ocular torsion incorporated into a miniaturized two-photon microscope, 42nd Annual Meeting of the Society for Neuroscience (Neuroscience 2012), New Orleans, LA, USA.
Schmitt AC Person, Wallace DJ Person, Sakmann B and Kerr JND Person (October-2009): Sensory evoked responses of interneurons in layers 1 and 2 of rat somatosensory cortex in vivo, 39th Annual Meeting of the Society for Neuroscience (Neuroscience 2009), Chicago, IL, USA.
Haydon Wallace DJ Person and Kerr JND Person (October-2009): Two-photon imaging of activity evoked in populations of neurons by simple visual stimuli in the primary visual cortex of awake rats, 39th Annual Meeting of the Society for Neuroscience (Neuroscience 2009), Chicago, IL, USA.
Sawinski J Person, Wallace DJ Person, Greenberg DS Person, Grossmann S , Denk W and Kerr JND Person (October-2009): Two-photon imaging of neuronal populations in the visual cortex of freely-moving animals, 39th Annual Meeting of the Society for Neuroscience (Neuroscience 2009), Chicago, IL, USA.
Meyer zum Alten Borgloh S , Wallace DJ Person, Astori S , Yang Y , Bausen M , Kügler S , Mank M , Griesbeck O , Nakai J , Miyawaki A , Palmer AE , Tsien RY , Sprengler R , Kerr JND Person, Denk W and Hasan MT (November-2008): Detection of single action potentials in vitro and in vivo with genetically-encoded Ca2+ sensors, 38th Annual Meeting of the Society for Neuroscience (Neuroscience 2008), Washington, DC, USA.

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Last updated: Friday, 17.01.2014