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Contact

Dr. Cesare Magri

Address: Spemannstr. 38
72076 Tübingen
Room number: 232
Phone: +49 (0)7071 601 1683
Fax: +49 7071 601 652
E-Mail: cesare.magri

 

Picture of Magri, Cesare, Dr.

Cesare Magri

Position: Research Scientist  Unit: Alumni Logothetis

The laminar distribution of sensory information conveyed by cortical LFPs

Cesare Magri

 

 

Introduction and Scientific Aim

Local Field Potentials (LFPs) are a massed signal that captures contributions from multiple neural phenomena, and that is sensitive to both supra- and sub-threshold processes. Previous work [1-2] has shown that stimulus encoding by LFPs can provide additional insight into sensory representations beyond that offered by neuronal spike trains and has documented the information content of different frequency components of the LFP [1]. However, little is yet known about how cortical microcircuits at different laminae contribute to the representation of naturalistic sensory information and about the characteristic frequencies of the information representation in each layer. Our aim is to investigate this issue by combining laminar cortical recordings with information-theoretic analysis.

 

 

Methods

We record laminar LFPs from the primary visual cortex of anesthetized macaques while presenting complex naturalistic movie stimuli. We develop new statistical methods to quantify how the information about the movie stimulus is encoded by the LFPs at different laminar locations and whether LFPs in different layers are tuned to similar stimulus features or share common sources of variability.

 

 

Results and Preliminary Conclusions

Our results show that differences in the stimulus-encoding properties of the LFPs recorded at different cortical depths do not simply stem from differences in LFP power. Higher power in an LFP band at a given cortical depth does not translate into higher stimulus-information encoded by that band at that particular depth. This is true, in particular, for the gamma band. Although the power in this frequency range is maximal in the middle layers, the stimulus-information conveyed by gamma power is higher in the top layers. Informative frequencies in the top layers included the gamma and high-gamma ranges while high-gamma carries little information in the bottom layers. Low frequencies are mostly informative in the middle and bottom layers. Our results suggest that LFP oscillations originating from different laminar circuits encode sensory information in a different fashion.

 

 

Collaborators

Yusuke Murayama, Stefano Panzeri

 

 

References

[1]     Belitski A, Gretton A, Magri C, Murayama Y, Montemurro MA, Logothetis NK and Panzeri S (2008) Low-frequency Local Field Potentials and Spikes in Primary Visual Cortex Convey Independent Visual Information Journal of Neuroscience 28(22) 5696-5709.

[2]     Montemurro MA, Rasch MJ, Murayama Y, Logothetis NK and Panzeri S (2008) Phase-of-Firing Coding of Natural Visual Stimuli in Primary Visual Cortex Current Biology 18(5) 375-380.

Figure Caption

Figure 1 – Information about a naturalistic color movie conveyed by the LFP spectrum recorded at different cortical depths. Results are plotted for a representative session (H05391). A) Distribution of gamma power measured at different cortical depth (mean and STD). B) The information conveyed about a complex naturalistic movie by single LFP frequencies at different cortical depths.


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Articles (10):

Magri C Person, Mazzoni A , Logothetis NK Person and Panzeri S Person (September-2012) Optimal Band Separation of Extracellular Field Potentials Journal of Neuroscience Methods 210(1) 66–78.
Eschenko O Person, Magri C Person, Panzeri S Person and Sara SJ (February-2012) Noradrenergic Neurons of the Locus Coeruleus Are Phase Locked to Cortical Up-Down States during Sleep Cerebral Cortex 22(2) 426-435.
Magri C Person, Schridde U Person, Murayama Y Person, Panzeri S Person and Logothetis NK Person (January-2012) The Amplitude and Timing of the BOLD Signal Reflects the Relationship between Local Field Potential Power at Different Frequencies Journal of Neuroscience 32(4) 1395-1407.
Magri C Person, Logothetis NK Person and Panzeri S Person (December-2011) Investigating static nonlinearities in neurovascular coupling Magnetic Resonance Imaging 29(10) 1358-1364.
Szymanski FD , Rabinowitz NC , Magri C Person, Panzeri S Person and Schnupp JWH (November-2011) The Laminar and Temporal Structure of Stimulus Information in the Phase of Field Potentials of Auditory Cortex Journal of Neuroscience 31(44) 15787-15801.
Belitski A Person, Panzeri S Person, Magri C Person, Logothetis NK Person and Kayser C Person (December-2010) Sensory information in local field potentials and spikes from visual and auditory cortices: time scales and frequency bands Journal of Computational Neuroscience 29(3) 533-545.
pdf
Magri C Person, Whittingstall K Person, Singh V Person, Logothetis NK Person and Panzeri S Person (July-2009) A toolbox for the fast information analysis of multiple-site LFP, EEG and spike train recordings BMC Neuroscience 10(81) 1-24.
Panzeri S Person, Magri C Person and Carraro L (October-2008) Sampling bias Scholarpedia 3(9) 4258.
Panzeri S Person, Magri C Person and Logothetis NK Person (September-2008) On the use of information theory for the analysis of the relationship between neural and imaging signals Magnetic Resonance Imaging 26(7) 1015-1025.
Belitski A Person, Gretton A Person, Magri C Person, Murayama Y Person, Montemurro MA , Logothetis NK Person and Panzeri S Person (May-2008) Low-frequency Local Field Potentials and Spikes in Primary Visual Cortex Convey Independent Visual Information Journal of Neuroscience 28(22) 5696-5709.

Contributions to books (1):

Panzeri S Person, Montani F , Notaro G , Magri C Person and Peterson RS : Population Coding, 303-319. In: Analysis of Parallel Spike Trains, (Ed) S. Grün, Springer, New York, NY, USA, (2010).

Posters (7):

Magri C Person, Mazzoni A , Logothetis NK Person and Panzeri S Person (November-2011): Optimal Band Separation of Local Field Potentials, 41st Annual Meeting of the Society for Neuroscience (Neuroscience 2011), Washington, DC, USA.
Schridde U Person, Magri C Person, Panzeri S Person and Logothetis NK Person (November-2011): Amplitude and timing of BOLD fMRI are related to specific LFP frequency bands, 41st Annual Meeting of the Society for Neuroscience (Neuroscience 2011), Washington, DC, USA.
Magri C Person, Schridde U Person, Panzeri S Person, Murayama Y Person and Logothetis NK Person (July-2011): Different LFP frequency bands convey complementary information about the BOLD signal, Twentieth Annual Computational Neuroscience Meeting (CNS*2011), Stockholm, Sweden, BMC Neuroscience, 12(Suppl 1) P204.
Magri C Person, Eschenko O Person, Panzeri S Person and Sara SJ (July-2010): Noradrenergic neurons of the locus coeruleus are phase-locked to cortical updown states during sleep, 26th International Summer School of Brain Research: Slow Brain Oscillations of Sleep, Resting State and Vigilance, Amsterdam, Netherlands.
pdf
Magri C Person, Whittingstall K Person, Singh V Person, Logothetis NK Person and Panzeri S Person (September-2009): Information breakdown analysis of simultaneous neural recordings: tools for the study of neural codes, 2nd INCF Congress of Neuroinformatics, Pilsen, Czech Republic, Frontiers in Neuroinformatics(Conference Abstract: Neuroinformatics 2009).
Mazzoni A , Brunel N , Kayser C Person, Magri C Person, Logothetis NK Person and Panzeri S Person (July-2009): Information content and robustness of various types of codes in integrate and fire networks presented with naturalistic stimuli, Eighteenth Annual Computational Neuroscience Meeting (CNS*2009), Berlin, Germany, BMC Neuroscience, 10(Suppl 1) P95.
Belitski A Person, Gretton A Person, Magri C Person, Murayama Y Person, Montemurro M , Logothetis NK Person and Panzeri S Person (November-2007): A time/frequency decomposition of information transmission by LFPs and spikes in the primary visual cortex, 37th Annual Meeting of the Society for Neuroscience (Neuroscience 2007), San Diego, CA, USA.

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Last updated: Friday, 17.01.2014