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Dr. Josef Pfeuffer

Josef Pfeuffer

Position: Projektleiter Abteilung: Alumni Logothetis

Publikationen

Artikel (45):
•	Cavusoglu M , Pfeuffer J , Ugurbil K und Uludag K (October-2009) Comparison of pulsed arterial spin labeling encoding schemes and absolute perfusion quantification Magnetic Resonance Imaging 27(8) 1039-1045.
•	Mishra R , Su W , Pohmann R , Pfeuffer J , Sauer MG , Ugurbil K und Engelmann J (September-2009) Cell-Penetrating Peptides and Peptide Nucleic Acid-Coupled MRI Contrast Agents: Evaluation of Cellular Delivery and Target Binding Bioconjugate Chemistry 20(10) 1860-1868.
•	Zappe A-C , Pfeuffer J , Merkle H , Logothetis NK und Goense JBM (March-2008) The effect of labeling parameters on perfusion-based fMRI in nonhuman primates Journal of Cerebral Blood Flow and Metabolism 28(3) 640-652.
•	Juchem C , Logothetis NK und Pfeuffer J (July-2007) (1)H-MRS of the macaque monkey primary visual cortex at 7 T: strategies and pitfalls of shimming at the brain surface Magnetic Resonance Imaging 25(6) 902-912.
•	Pfeuffer J , Shmuel A , Keliris GA , Steudel T , Merkle H und Logothetis NK (July-2007) Functional MR imaging in the awake monkey: effects of motion on dynamic off-resonance and processing strategies Magnetic Resonance Imaging 25(6) 869-882.
•	Zappe A-C , Reichold J , Burger C , Weber B , Buck A , Pfeuffer J und Logothetis NK (July-2007) Quantification of Cerebral Blood Flow in Nonhuman Primates Using Arterial Spin Labeling and a Two-Compartment Model Magnetic Resonance Imaging 25(6) 775-783.
•	Keliris GA , Shmuel A , Ku S-P , Pfeuffer J , Oeltermann A , Steudel T und Logothetis NK (July-2007) Robust Controlled Functional MRI in Alert Monkeys at High Magnetic Field: Effects of Jaw and Body Movements NeuroImage 36(3) 550-570.
•	Su W , Mishra R , Pfeuffer J , Wiesmüller KH , Ugurbil K und Engelmann J (February-2007) Synthesis and cellular uptake of a MR contrast agent coupled to an antisense peptide nucleic acid - cell- penetrating peptide conjugate Contrast Media and Molecular Imaging 2(1) 42-49.
•	Juchem C , Mueller-Bierl B , Schick F , Logothetis NK und Pfeuffer J (September-2006) Combined Passive and Active Shimming for In Vivo MR Spectroscopy at High Magnetic Field Journal of Magnetic Resonance 183(2) 278-289.
•	Mishra A , Pfeuffer J , Mishra R , Engelmann J , Mishra A , Ugurbil K und Logothetis NK (April-2006) A New Class of Gd-based DO3A-ethylamine-derived Targeted Contrast Agents for MR and Optical Imaging. Bioconjugate Chemistry 17(3) 773-780.
•	Juchem C , Logothetis NK und Pfeuffer J (October-2005) High-resolution 1H chemical shift imaging in the monkey visual cortex Magnetic Resonance in Medicine 54(6) 1541-1546.
•	Pfeuffer J , Lin J , DelaBarre L , Ugurbil K und Garwood M (2005) Detection of intracellular lactate with localized diffusion {1H-13C}-spectroscopy in rat glioma in vivo J. Magn. Reson. 177(1) 129-138.
•	Pfeuffer J , Merkle H , Beyerlein M , Steudel T und Logothetis NK (December-2004) Anatomical and Functional MR Imaging in the Macaque Monkey Using a Vertical Large-bore 7 Tesla Setup Magnetic Resonance Imaging 22(10) 1343-1359.
•	Pfeuffer J , Juchem C , Merkle H , Nauerth A und Logothetis NK (December-2004) High-field localized 1H NMR spectroscopy in the anaesthetized and in the awake monkey Magnetic Resonance Imaging 22(10) 1361-1372.
•	Logothetis NK und Pfeuffer J (December-2004) On the Nature of the BOLD fMRI Contrast Mechanism Magnetic Resonance Imaging 22(10) 1517-1531.
•	Juchem C , Merkle H , Schick F , Logothetis NK und Pfeuffer J (December-2004) Region and volume dependencies in spectral linewidth assessed by 1H 2D MR chemical shift imaging in the monkey brain at 7T Magnetic Resonance Imaging 22(10) 1373-1383.
•	Pfeuffer J , McCullough JC , de Moortele P-FV , Ugurbil K und Hu X (April-2003) Spatial dependence of the nonlinear BOLD response at short stimulus duration Neuroimage 18(4) 990-1000.
•	Shmuel A , Yacoub E , Pfeuffer J , Ugurbil K und Al E (December-2002) Sustained negative BOLD, blood flow and oxygen consumption response and its coupling to the positive response in the human brain Neuron 36(6) 1195-1210.
•	Pfeuffer J , de Moortele P-FV , Yacoub E , Shmuel A , Adriany G , Andersen P , Merkle H , Garwood M , Ugurbil K und Hu X (September-2002) Zoomed Functional Imaging in the Human Brain at 7 Tesla with Simultaneous High Spatial and High Temporal Resolution NeuroImage 17(1) 272-286.
•	Pfeuffer J , Adriany G , Shmuel A , Yacoub E , de Moortele P-FV , Hu X und Ugurbil K (May-2002) Perfusion-based high-resolution functional imaging in the human brain at 7 Tesla Magnetic Resonance in Medicine 47(5) 903-911.
•	Pfeuffer J , de Moortele P-FV , Ugurbil K , Hu X und Glover GH (February-2002) Correction of physiologically induced global off-resonance effects in dynamic echo-planar and spiral functional imaging Magnetic Resonance in Medicine 47(2) 344-353.
•	Wenking H , Yacoub E , Pfeuffer J , Shmuel A , de Moortele PV , Adriany G und Ugurbil K (2002) Mapping Human Brain Function with MRI at 7 Tesla Chinese Journal of Magnetic Resonance 19(1).
•	Van de Moortele P-F , Pfeuffer J , Glover GH , Ugurbil K und Hu X (2002) Respiration-Induced B0 Fluctuations in the Human Brain at 7 Tesla and its Spatial Distribution Magn Reson Med (47) 888-895.
•	Zhang X , de Moortele P-FV , Pfeuffer J und Hu X (2001) Elimination of k-space spikes in fMRI data Magnetic Resonance Imaging 19 1037-1041.
•	Yacoub E , Shmuel A , Pfeuffer J , de Moortele PV , Adriany G , Andersen P , Vaughan J , Merkle H , Ugurbil K und Hu X (2001) Imaging Brain Function in Humans at 7 Tesla Magnetic Resonance in Medicine 45 588-594.
•	Yacoub E , Shmuel A , Pfeuffer J , de Moortele P-FV , Adriany G , Ugurbil K und Hu X (2001) Investigation of the Initial Dip at 7 Tesla NMR in Biomedicine 14 408-412.
•	Ugurbil K , Shmuel A , Pfeuffer J und Al E (2001) Magnetic Resonance Imaging of Brain Function and Neurochemistry Proceeding of the IEEE 89(7) 1093-1140.
•	Tkac I , Keene CD , Pfeuffer J , Low WC und Gruetter R (2001) Metabolic changes in quinolinic acid-lesioned rat striatum measured non-invasively by in vivo 1H NMR spectroscopy Journal of Neuroscience Research 66 891-898.
•	Zwingmann C , Floegel U , Pfeuffer J und Leibfritz D (September-2000) Effects of Ammonia Exposition on Glioma Cells: Changes in Cell Volume and Organic Osmolytes Studied by Diffusion-Weighted and High-Resolution NMR Spectroscopy Developmental Neuroscience 22(5-6) 463-471.
•	Leibfritz D , Pfeuffer J , Floegel U , Meier C und Broer S (2000) Cell volume and water exchange in neural cells monitored by diffusion weighted 1H NMR spectroscopy. In "Volume Transmission Revisted" (Eds.: Luigi Agnati, Kjell Fuxe, Charles Nicholson, Eva Sykova) Prog Brain Res, Elsevier 125 255-263.
•	Pfeuffer J , Tkac I und Gruetter R (2000) Extracellular-intracellular distribution of glucose and lactate in the rat brain assessed noninvasively by diffusion-weighted 1H nuclear magnetic resonance spectroscopy in vivo. J. Cereb. Blood Flow Metab. 20 736-746.
•	Pfeuffer J , Tkac I , Choi IY , Merkle H , Ugurbil K , Garwood M und Gruetter R (1999) Localized in vivo 1H NMR detection of neurotransmitter labeling in rat brain during infusion of [1-13C] D-glucose Magn Reson Med 41 1077-1083.
•	Gruetter R , Pfeuffer J , Tkac I , Damberg G und Seaquist ER (1999) NMR STUDIES OF IN VIVO BRAIN GLUCOSE CONCENTRATIONS AND TRANSPORT. Paulson,O., Knudsen,G.M. & Moos,T. (eds.), Munksgaard, Copenhagen. Brain Barrier Systems, Alfred Benzon Symposium 45 128-138.
•	Pfeuffer J , Tkac I , Provencher SW und Gruetter R (1999) Toward an in vivo neurochemical profile: quantification of 18 metabolites in short-echo-time 1H NMR spectra of the rat brain. J Magn Reson 141 104-120.
•	Pfeuffer J , Provencher SW und Gruetter R (1999) Water diffusion in rat brain in vivo as detected at very large b values is multicompartmental MAGMA 8 98-108.
•	Pfeuffer J , Broer S , Broer A , Lechte M , Floegel U und Leibfritz D (1998) Expression of Aquaporins in Xenopus laevis Oocytes and Glial Cells as Detected by Diffusion-Weighted 1H NMR Spectroscopy and Photometric Swelling Assay. Biochimica et Biophysica Acta 1448 27-36.
•	Henke J , Engelmann J , Floegel U , Pfeuffer J , Kutscher B , Noessner G , Engel J , Voegeli R und Leibfritz D (1998) Investigations on the apoptotic effects of hexadecylphosphocholine on resistant and non-resistant cells monitored by NMR spectroscopy. Drugs of Today 34 (Suppl. F) 37-50.
•	Pfeuffer J , Floegel U und Leibfritz D (1998) Monitoring of cell volume and water exchange time in perfused cells by diffusion-weighted 1H NMR spectroscopy. NMR in Biomedicine 11 11-18.
•	Pfeuffer J , Floegel U , Dreher W und Leibfritz D (1998) Restricted diffusion and exchange of intracellular water: theoretical modelling and diffusion time dependence of 1H NMR measurements on perfused glial cells. NMR in Biomedicine 11 19-31.
•	Pfeuffer J , Dreher W , Sykova E und Leibfritz D (1998) Water signal attenuation in diffusion-weighted 1H NMR experiments during cerebral ischemia: Influence of intracellular restrictions, extracellular tortuosity, and exchange. Magnetic Resonance Imaging 16 1023-1032.
•	Serkova N , Christians U , Floegel U , Pfeuffer J und Leibfritz D (1997) Assessment of the mechanism of astrocyte swelling induced by the macrolide immunosuppressant sirolimus using multinuclear nuclear magnetic resonance spectroscopy. Chemical Research in Toxicology 10 1359-1363.
•	Floegel U , Willker W , Pfeuffer J und Leibfritz D (1997) Regulation of Glial Lipid Metabolism During Osmotic Stress Studied by 13C-NMR Spectroscopy. Neurochemistry, ed by A W Teelken and J Korf. Plenum , New York pp. 571-575. Neurochemistry 571-575.
•	Grupp A , Pfeuffer J und Mehring M (1995) 13C Hyperfine Interaction in the Triplet State of C60: An Electron Spin Echo Envelope Modulation Study. Eds. H. Kuzmany, J. Fink, M. Mehring, S. Roth. World Scientific in: 'Physics and chemistry of fullerenes and derivates' 246-249.
•	Floegel U , Pfeuffer J und Leibfritz D (1995) Effect of Ibuprofen on Swelling-induced Alterations in Cell Metabolism, Studied by Multinuclear NMR Spectroscopy. Research Report, Dolorgiet .
•	Pfeuffer J und Presting H (1992) Modeling of recombination mechanisms in the electronic transport of p-n transitions] Modellierung von Rekombinationsmechanismen beim Stromtransport in p-n-Übergangen. Research Report, Daimler-Benz Research Center, Ulm 1 1-1.
Beiträge zu Tagungsbänden (4):
•	Pfeuffer J , Steudel T , Merkle H und Logothetis NK (March-2004) Perfusion-based high-resolution fMRI in the primate brain using a novel vertical large-bore 7 Tesla setup ISMRM Workshop on Quantitative Cerebral Perfusion Imaging Using MRI: A Technical Perspective, 108-109.
•	Pfeuffer J (March-2002) Diffusion-Weighted Spectroscopy of Water and Cerebral Metabolites at Very Large b Values: What Multiple Components Tell Us Workshop of the ISMRM "Diffusion MRI: Biophysical Issues", 41-44.
•	Shmuel A , Yacoub E , Pfeuffer J , Ugurbil K und Koller EA (2002) The Spatial Pattern of the Positive BOLD Response at High Magnetic Field is Approximately Stationary International Conference on Functional Mapping of the Human Brain, NeuroImage, 16, 562-562.
•	Shmuel A , Yacoub E , Pfeuffer J , Moortele P-FVD , Adriany G , Ugurbil K und Hu X (2001) Negative BOLD response and its coupling to the positive response in the human brain International Conference on Functional Mapping of the Human Brain, NeuroImage, 13, 1005-1005.
Technische Berichte (2):
•	Jayachandra MR , Logothetis NK und Pfeuffer J : Comparison of experimental and theoretical spiral MR trajectories, 129, Max Planck Institute for Biological Cybernetics, (August-2004).