Kontakt

Dr. phil. Gisela Hagberg

Adresse: Spemannstr. 41
72076 Tübingen
Raum Nummer: 3.B.09
Tel.: 07071 601 1648
Fax: 07071 601 652
E-Mail: gisela.hagberg

 

Bild von Hagberg, Gisela, Dr. phil.

Gisela Hagberg

Position: Gastwissenschaftler  Abteilung: Scheffler

Anwendungen der Hoch-Feld MRT in klinisch-wissenschaftlichen Studien

Ultra-hohe Magnetfelder erlauben sehr detaillierte, nicht-invasive, strukturelle und funktionelle Untersuchungen des menschlichen Gehirns.

 

MR-basierte Signale entstehen wiederum auf einer noch mehr detaillierteren Ebene, auf Grund kleiner Bewegungen der Wasser Moleküle durch die anatomische Vielfalt des Gehirns.  Die Gewebsstruktur und ihre Zusammensetzung erzeugen lokale magnetische Effekte auf das Wasser, die mit der Gehirn-Funktion oder Pathologische Prozesse sich stets in Wandel befinden.

 

Der  Schwerpunkt meiner Forschung liegt im Bereich der Untersuchung solche pathophysiologische Prozesse mit MR Methoden. Hierbei möchte ich herausfinden wie im MR Bild Kontraste erzeugt und quantifiziert werden können die der mikrostrukturellen und funktionellen Einflüsse entsprechen.  Das Ziel ist es Methoden bei Ultrahohe Magnetfeldern zu erarbeiten, die quantitative anatomische und funktionelle MR Studien erlauben und neue medizinische Nutzfelder ermöglichen.

Characterization of tissue heterogeneity in glial brain tumors

In this project we used Time-of-Flight (ToF) MRI, and SWI to pinpoint angiogenesis [1,2], while quantification of R2*/T2* and susceptibility was employed to characterize alterations of the tissue microstructure.

ToF imaging was possible to perform at high-fields, despite severe restrictions on the specific absorption rate. The short T2* of venous blood allowed suppression of unwanted signals through the use of long TE times [1]. However, the fine arteries inside tumors located at the cortical surface were not detectable by this approach,  probably owing to weak excitation.  We foresee that future use of pTX transmission technology will greatly enhance the possibility to visualize arteries under these circumstances.

In quantitative R2* maps, the poorly regulated blood and oxygen supply in tumors may hamper the visibility of the venous vessels. Nevertheless, through the enhanced sensitivity to susceptibility effects and fine resolution available at UHF, small veins and blood clots could be observed in R2* maps, while delineation of the tumor mass itself was excellent in quantitative T2* images.

We also found that quantification of susceptibility effects is helpful to detect local tumor tissue heterogeneity and through use of QSM, we could distinguish between blood clots and calcifications, as those typically encountered in oligodendroglioma tumors [2]. Key to these results was the development of methods to process the MRI phase images, which are used for QSM quantification [3].

 

Fig1: MRI at 9.4T of a patient with an oligodendroglioma showing: SWI–based minIP across 5mm (5slice); a): CT in Hounsfield Units; b): a phase image (in radians) obtained after spline filtering [3] (TE 14ms at 9.4T) showing the vessel and positive and negative phase changes inside the non-enhancing tissue; c): QSM map showing the local susceptibility values obtained from the filtered phase and modulus 3D gradient echo images, with increased susceptibility in the vessel (arrow) and a contiguous area in non-enhancing tissue, consistent with a calcification [2].

 

Molecular Imaging based MRI: the quest for high sensitivity at high fields

Dependent on the T1 and T2 time of the nuclear spins observed, imaging parameters that allow optimal contrast or the maximal signal to noise ratio can be derived. This step is critical to get the most out of molecular imagiing approaches, regardless of the compound used. In two separate projects we explored different approaches and determined the available MR signal. For 19F compounds we characterized the MRI method that yields the highest SNR per unit time, and showed how the agent itself influences detection sensitivity [4]. For Gadolinium-based compounds often used in clinical research, we charactarized  their performance at 3T, 7T and 9,4T in terms of the necessary dose and detection sensitivity, both as a function of imaging parameters [5].  We found that 10-15% lower contrast agent doses can be administered to the patients, provided that the relaxivity remains the same at 9.4T, holding promise for clinical research applications exploiting contrast agents at UHF.

 

Fig2: Relative signal as a function of T2 and the T2/T1 ratio when using the best imaging parameters for each sequence within a fixed scan time.

 

References

[1] Hagberg GE, Martirosian P, Bause J, Chadzynski GL,Pohmann R, Shajan G, Klose U, Scheffler K. (2013) Time-of-flight angiography in Humans at 94T Proc. Intl. Soc. Mag. Reson. Med. 21 1135

[2]  Hagberg GE, Balla DZ, Bisdas S, Budde J, Pohmann R, Klose U, Ethofer T, Scheffler K (2013) Localization of calcifications in an oligodendroglioma by quantitative susceptibility mapping at 9.4T presented at: ISMRM Scientific Workshop on Ultra High Field MRI 2-5 March, Nordwijk aan Zee, The Netherlands

[3]  Hagberg GE, Scheffler KS (2014) Model-free phase processing of multi-gradient-echo images at 9.4T Proc. Intl. Soc. Mag. Reson. Med. 22 3261

[4] Hagberg GE, Keliris A, Mamedov I, Placidi M, Merkle H,  Logothetis NK, Scheffler K. (2013) 19F-lanthanide complexes: T1- and T2-dependent signal gain using gradient echoes. Proc. Intl. Soc. Mag. Reson. Med. 21 1891

[5] Hagberg GE, Scheffler K.(2013) Effect of r₁ and r₂ relaxivity of gadolinium-based contrast agents on the T₁-weighted MR signal at increasing magnetic field strengths. Contrast Media Mol Imaging8(6):456-65.

Wissenschaftlicher Werdegang
Seit 06/2012    Projektleiterin, Hochfeld Magnetresonanz, Max-Planck-Institut für Biologische Kybernetik  und Abt. Biomedizinische Magnetresonanz, Universitätsklinikum Tübingen, Deutschland
09/10-05/12    Wissenschaftliche Mitarbeiterin, Max-Planck-Institut für Biologische Kybernetik, Abt. Physiologie kognitiver Prozesse, Tübingen, Deutschland
06/06-08/10    Gruppenleiterin MR Physik, Fondazione Santa Lucia IRCCS, Rom, Italien;
12/2007    Medizin Physik Expertin (MPE), Università Sapienza, Rom, Italien
04/99-06/06    Wissensch. Mitarbeiterin, Fondazione Santa Lucia IRCCS, Rom, Italien
03/99-03/03    Wissensch. Mitarbeiterin, 10% PET centre, Uppsala Universität, Schweden
06/96-02/99        Wissensch. Mitarbeiterin (100%) Positron EmissionTomography (PET) Centre, Uppsala Universität, Schweden
12/94-12/95    Post-Doktorandin, Dep. Pharmacokinetics, Pharmacia&Upjohn, Milano, Italien
07/93-06/94    Post-Doktorandin, Abt. Biophysikalische Chemie, Universität Basel, Schweiz
06/1993    Doktor der Philosophie, verliehen durch die Universität Basel, Schweiz
Thema: Metabolism of the Human Brain Investigated by 1H-MRS
06/90-06/93    Doktorandin, Abt. Biophysikalische Chemie, Universität Basel, Schweiz
10/90        Diplom-Ingenieur Physik, Lunds Tekniska Högskola (LTH) Schweden
01/90        Diplom-Ingenieur Physik Ecole Polytechnique Fédérale de Lausanne, Schweiz
04/88-01/90    Hauptstudium der Physik an der Ecole Polytechnique Fédérale de Lausanne, Schweiz, im Rahmen eines europäischen Doppeldiplomprogramms mit den Schwerpunkten Physik und allgemeine Ingenieurwissenschaften
09/85-03/88    Grundstudium der Physik an Lunds Tekniska Högskola (LTH) Schweden

Publikationen

Anzahl insgesamt: 62 peer-reviewed; 5 Buchkapiteln, 3 Patente, h-index 22; i10: 39 (see: http://www.researcherid.com/rid/A-2134-2010)

Mitgliedschaft
•    Society for Magnetic Resonance in Medicine, ISMRM
•    Italienische Gesellschaft für Medizinische Physik, AIFM
•    Italienischer Verband für Strahlungs Forschung, FIRR
•    European Society for Molecular Imaging

Eingeworbene Drittmittel
05/13 – 04/15 Functional neuroimaging of the human brainstem at 9.4T Werner Reichardt Centre for Integrative Neurosciences    
04/06 - 03/08 Cognitive control during aging: physiology of decline and preclinical evaluation Italian Ministry of Health
04/01 – 03/03 Prognosis for functional motor recovery post-stroke: a study of anatomically correlated neurophysiology Italian Ministry of Health
04/01 – 03/03 Neuropsychological, genetic and neurobiological basis of cerebellar injury Italian Ministry of Health     

Gremienarbeit
Gremiums-Mitglied der Italienischer Verband für Strahlungs Forschung, FIRR, 2008-2012
Scientific Committe:
•    Tagungen der AIFM: 2011 und 2013
•    EFOMP/ESMRMB/AIFM Kurs, Udine 22-15.10.2010
Advances in High Field Magnetic Resonance Imaging
•    Workshop, FIRR, Rom 14.5.2009
Radiation: Biology, Clinic, Environment, und Protection

Lehre
Lehrveranstaltungen: Universität Tübingen (MRI Kontrast im Rahmen der Medizintechnik); Universität Tor Vergata, Rom (Angewandte Physik); Fondazione Santa Lucia (Brain Imaging)
Betreuung von Studenten und Doktoranden: Phd (3); MSc (3); Spezialisierung der Medizinphysik (1)
Eingeladen Vorträge: Karolinska Institutet - Stockholm, CNR - Genova, International School on Magnetic Resonance and Brain Function – Erice, Strasbourg, France, Radboud University, Nijmegen, The Netherlands; Workshops und Kongresse: AIFM und ISMRM

Präferenzen: 
Referenzen pro Seite: Jahr: Medium:

  
Zeige Zusammenfassung

Artikel (8):

Balla DZ Person, Sanchez-Panchuelo RM , Wharton SJ , Hagberg GE Person, Scheffler K Person, Francis ST und Bowtell R (Oktober-2014) Functional quantitative susceptibility mapping (fQSM) NeuroImage 100 112–124.
Kadjane P Person, Platas-Iglesias C , Boehm-Sturm P , Truffault V , Hagberg GE Person, Hoehn M , Logothetis NK Person und Angelovski G Person (Juni-2014) Dual-Frequency Calcium-Responsive MRI Agents Chemistry: A European Journal 20(24) 7351–7362.
Angelovski G Person, Gottschalk S Person, Milošević M , Engelmann J Person, Hagberg GE Person, Kadjane P Person, Andjus P und Logothetis NK Person (Mai-2014) Investigation of a Calcium-Responsive Contrast Agent in Cellular Model Systems: Feasibility for Use as a Smart Molecular Probe in Functional MRI ACS Chemical Neuroscience 5(5) 360–369.
Hagberg G Person, Mamedov I Person, Power A Person, Beyerlein M Person, Merkle H Person, Kiselev VG , Dhingra K Person, Kubìček V , Angelovski G Person und Logothetis NK Person (Januar-2014) Diffusion properties of conventional and calcium-sensitive MRI contrast agents in the rat cerebral cortex Contrast Media & Molecular Imaging 9(1) 71–82.
Hagberg GE Person und Scheffler K Person (Dezember-2013) Effect of r1 and r2 relaxivity of gadolinium‐based contrast agents on the T1‐weighted MR signal at increasing magnetic field strengths Contrast Media & Molecular Imaging 8(6) 456–465.
Placidi MP Person, Botta M , Kálmán FK , Hagberg GE Person, Baranyai Z , Krenzer A , Rogerson AK , Tóth I , Logothetis NK Person und Angelovski G Person (August-2013) Aryl-Phosphonate Lanthanide Complexes and Their Fluorinated Derivatives: Investigation of Their Unusual Relaxometric Behavior and Potential Application as Dual Frequency 1H/19F MRI Probes Chemistry - A European Journal 19(35) 11644–11660.
Pohmann R Person, Shajan G Person, Hoffmann J Person, Budde J Person, Hagberg G Person, Bieri O , Bisdas S , Ernemann U , Weigel M , Ehses P Person, Hennig J , Chadzynski G und Scheffler K Person (April-2013) Imaging and Spectroscopy at 9.4 Tesla: First Results on Patients and Volunteers MAGNETOM Flash 2013(2) 58-67.
Keliris A Person, Mamedov I Person, Hagberg GE Person, Logothetis NK Person, Scheffler K Person und Engelmann J Person (September-2012) A smart 19F and 1H MRI probe with self-immolative linker as a versatile tool for detection of enzymes Contrast Media & Molecular Imaging 7(5) 478–483.

Beiträge zu Büchern (1):

Hagberg GE Person und Tuzzi E : Phase Variations in fMRI Time Series Analysis: Friend or Foe?, 81-113. In: Advanced Brain Neuroimaging Topics in Health and Disease: Methods and Applications, (Ed) T.D. Papageorgiou, InTech, Rijeka, Croatia, (Mai-2014).

Poster (14):

Chadzynski G Person, Hagberg GE Person, Bause J Person, Shajan G Person, Bisdas S , Pohmann R Person, Engelmann J Person und Scheffler K Person (März-20-2015): Assessment of human brain tumors with proton magnetic resonance spectroscopic imaging at 9.4 Tesla, 10th Annual Meeting of the European Society for Molecular Imaging (EMIM 2015), Tübingen, Germany.
Hagberg GE Person, Keliris A Person, Srinivas M , Schulz H Person, Engelmann J Person, Schmehl J , Bantleon R und Scheffler K Person (März-19-2015): Characterization and MRI detection of 19F-PLGA labelled human mesenchymal stem cells, 10th Annual Meeting of the European Society for Molecular Imaging (EMIM 2015), Tübingen, Germany.
Chadzynski G Person, Bause J Person, Hagberg GE Person, Shajan G Person, Pohmann R Person, Engelmann J Person und Scheffler K Person (März-19-2015): Free induction decay proton magnetic resonance spectroscopic imaging in the healthy human brain at 9.4 Tesla: initial results, 10th Annual Meeting of the European Society for Molecular Imaging (EMIM 2015), Tübingen, Germany.
Keliris A Person, Engelmann J Person, Hagberg GE Person und Scheffler K Person (März-19-2015): Self-assembling peptide based system for detection of enzymatic activity by means of MRI, 10th Annual Meeting of the European Society for Molecular Imaging (EMIM 2015), Tübingen, Germany.
Sánchez-Castañeda C , Hagberg G Person, Squitieri F und Sabatini U (September-2014): Progressive Iron Accumulation In Huntington Disease Basal Ganglia: A Longitudinal Study, European Huntington’s Disease Network 8th Plenary Meeting, Barcelona, Spain, Journal of Neurology, Neurosurgery & Psychiatry, 85(Suppelment 1) A37-A38.
Hagberg GE Person, Martirosian P , Bause J Person, Shajan G Person, Klose U und Scheffler K Person (April-25-2013): Time-Of-Flight Angiography in Humans at 9.4T, 21st Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT, USA.
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Hagberg GE Person, Keliris A Person, Mamedov I Person, Placidi M Person, Merkle H Person, Logothetis NK Person und Scheffler K Person (April-23-2013): 19F-Lanthanide Complexes: T1 - and T2 - Dependent Signal Gain Using Gradient Echoes, 21st Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT, USA.
pdf
Chadzynski G Person, Bisdas S , Hagberg G Person, Pohmann R Person, Shajan G Person, Kolb R , Klose U und Scheffler K Person (April-23-2013): First Proton CSI of a Human Brain Tumor at 9.4T, 21st Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT, USA.
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Hagberg GE Person, Mamedov I Person, Power A Person, Beyerlein M Person, Merckle H , Dhingra K Person, Kubicek V und Logothetis NK Person (November-2012): Diffusion of conventional and calcium sensitive MRI contrast agents in the rat cerebral cortex, Fifth Annual World Molecular Imaging Congress (WMIC 2012), Dublin, Ireland, Molecular Imaging and Biology, 14(2 Supplement) S1544.
Keliris A Person, Mamedov I Person, Hagberg GE Person, Logothetis NK Person, Scheffler K Person und Engelmann J Person (November-2012): Dual 1H/19F MR imaging approach for detection of enzyme activity, Fifth Annual World Molecular Imaging Congress (WMIC 2012), Dublin, Ireland, Molecular Imaging and Biology, 14(2 Supplement) S1235.
Hagberg GE Person, Mamedov I Person, Placidi M Person, Keliris A Person, Merkle H Person, Logothetis NK Person und Scheffler K Person (Oktober-29-2012): 19F-Lanthanide complexes: T1- and T2-dependent signal gain using gradient echoes, ENCITE Symposium "Red hot MRI: In vivo 19F imaging", Nijmegen, The Netherlands.
Hagberg GE Person, Mamedov I Person, Power A Person, Beyerlein M Person, Merkle H Person, Angelovski G Person und Logothetis NK Person (Mai-9-2012): Diffusion in the extra-cellular space of the rat cerebral cortex probed by MRI and direct infusion of contrast agents, 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia.
Mamedov I Person, Engelmann J Person, Hagberg G Person, Eschenko O Person und Logothetis NK Person (Mai-8-2012): Development of multimodal imaging probes for neuroanatomical connectivity studies in vivo by means of MRI, 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia.
Hagberg GE Person, Balla D Person, Wiesner HM Person und Logothetis NK Person (Mai-9-2011): Small-Scale Phase & Magnitude Fluctuations in fMRI Time Series, 19th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2011), Montréal, Canada.

Vorträge (7):

Chadzynski GK Person, Hagberg G Person, Bause J Person, Shajan G Person, Bisdas S , Pohmann R Person und Scheffler K Person (Juni-5-2015) Abstract Talk: In-vivo proton MR spectroscopic imaging of the human brain gliomas at 9.4 Tesla: evaluation of metabolite coordinates, 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada(0763).
Hagberg G Person (Oktober-24-2013) Invited Lecture: First clinical studies at 9.4T: hurdles and opportunities, 4th Annual Meeting by the Italian Chapter of the ISMRM: Risonanza Magnetica in Medicina 2013:, Perugia, Italy.
Keliris A Person, Hagberg GE Person, Engelmann J Person und Scheffler K Person (Mai-26-2013) Abstract Talk: Dual modality approach for detection of enzyme activity by means of 1H/19F MRI, 8th European Molecular Imaging Meeting (EMIM 2013), Torino, Italy(298).
Balla DZ Person, Sanchez Panchuelo RM , Wharton SJ , Hagberg GE Person, Scheffler K Person, Francis ST und Bowtell RW (April-23-2013) Abstract Talk: Experimental investigation of the relation between gradient echo BOLD fMRI contrast and underlying susceptibility changes at 7T, 21st Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT, USA 910.
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Mamedov I Person, Engelmann J Person, Hagberg GE Person, Logothetis NK Person, Gambino G , Tei L und Botta M (November-2012) Abstract Talk: Development of multimodal imaging probes for neuroanatomical connectivity studies in vivo, Fifth Annual World Molecular Imaging Congress (WMIC 2012), Dublin, Ireland, Molecular Imaging and Biology, 14(2 Supplement) S1901.
Hagberg G Person (Oktober-25-2012) Invited Lecture: 19F-Lanthanide complexes: T1 and T2-dependent signal gain using gradient echoes, Nijmegen Center for Molecular Life Sciences: Radboud University, Nijmegen, The Netherlands.
Balla DZ Person, Sanchez-Panchuelo RM , Wharton S , Hagberg GE Person, Scheffler K Person, Francis ST und Bowtell RW (Mai-8-2012) Abstract Talk: Functional Quantitative Susceptibility Mapping (fQSM), 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia(325).

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Last updated: Dienstag, 18.11.2014