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Prof. Dr. Nikos Logothetis

Adresse: Spemannstr. 38
72076 Tübingen
Raum Nummer: 121
Tel.: 07071 601 651
Fax: 07071 601 652
E-Mail: nikos.logothetis

 

Bild von Logothetis, Nikos, Prof. Dr.

Nikos Logothetis

Position: Direktor  Abteilung: Logothetis

Research in this laboratory concentrates on the neural mechanisms of perception and object recognition. Although our basic research revolves around vision, a number of independent collaborators are also investigating the relationship between neural activity and perception using other sensory modalities. I firmly believe that such scientific questions require a multimodal methodological approach that integrates information obtained from single units with that derived from mass action potentials as well as from a number of activity-related, surrogate signals such as those monitored during noninvasive experiments. Parallel to our ongoing research, therefore, we are also working to develop methodologies that will permit us to study neural networks in the context of behavioral paradigms. We have already designed and implemented two high-field magnetic resonance imaging systems for functional, anatomical and spectroscopic imaging. The systems are endowed with all the necessary hard- and software to conduct simultaneous imaging and recordings, and they are being used to study the function, connectivity, and neurochemistry of the non-human primate brain. Furthermore, while continuing to exploit traditional neuroimaging in our experiments, we are also investigating the relationship of neural activity to the MR-measurable hemodynamic responses and experimenting with methods that do not rely on hemodynamic responses at all. In the context of the last-named project, a group of synthetic and coordination chemists in my laboratory are attempting to synthesize and evaluate MR-detectable smart probes that change magnetic properties as a function of the concentration of ions and molecules involved in neural signaling. Smart contrast agents, if designed and tested appropriately, promise to revolutionize invasive neuroimaging and would represent a quantum leap forward in signal-to-noise ratio, spatial detail and specificity, while affording unprecedented temporal resolution.
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Nikos K. Logothetis is director of the department “Physiology of Cognitive Processes” at the Max Planck Institute for Biological Cybernetics (MPIK), in Tübingen, Germany. He received a B.S. in mathematics from the University of Athens, a B.S. in biology from the University of Thessaloniki, and his Ph.D. in human neurobiology from the Ludwig-Maximilians University in Munich. In 1985 he moved to the Brain and Cognitive Sciences Department of M.I.T., where he initially worked as a postdoctoral fellow and later as Research Scientist. In 1990 he joined the faculty of the Division of Neuroscience at the Baylor College of Medicine. Seven years later he moved to the Max Planck Institute for Biological Cybernetics to continue his work on the physiological mechanisms underlying visual perception and object recognition.

In addition to visual cognition, his work at MPIC includes auditory perception and multisensory integration, as well as studies of plasticity and neuromodulation. Parallel to this ongoing research, a number of methods have been developed that permit the study of neural networks in the context of behavioral paradigms. Two high-field magnetic resonance imaging systems were designed and implemented for functional, anatomical and spectroscopic imaging. They permit simultaneous imaging and intracortical recordings and are being used to study the function, connectivity, and neurochemistry of the non-human primate brain, as well as the relationship of neural activity to the MR-measurable hemodynamic responses. Last but not least a group of synthetic and coordination chemists at MPIC are attempting to synthesize and evaluate MR-detectable smart probes that change magnetic properties as a function of the concentration of ions and molecules involved in neural signaling.

Since 1992 Nikos K. Logothetis has been Adjunct Professor of Neurobiology at the Salk Institute in San Diego, since 1995 Adjunct Professor of Ophthalmology at the Baylor College of Medicine, Houston, Associate of the Neurosciences Institute, San Diego, Senior Visiting Fellow in University College, London, Adjunct Professor in the Department of Cognitive and Neural Systems and of Cognitive and Neural Systems in the College of Arts and Sciences, both at the Boston University, Massachusetts, a  faculty member at the Victoria University of Manchester (VUM) in England, and Honorary Professor in the Department of Biology at the University of Tübingen.

Nikos K. Logothetis has been or continues to be a member of the Advisory Boards of McGovern Institute, M.I.T.; Brain and Cognitive Sciences, M.I.T., USA; POSIT Science Corporation, San Francisco, USA; IGPS, Freiburg, Germany; Centre of Excellence in Systems Neuroscience of the Academy of Finland, Helsinki, Finland; Brain Imaging Center, Frankfurt am Main, Germany; ICM-ADREC, Paris, France; Brain Center of the Hebrew University, Jerusalem, Israel, and in the Advisory Board of the Brain Research Center of the Weizmann Institute, Jerusalem, Israel.  He served as Receiving Editor for the European Journal of Neuroscience (EJN), Associate Editor for Trends in Cognitive Sciences (TICS), Neuron, Current Biology, Current Opinion Neurobiology, and is a regular reviewer for Nature, Nature Neuroscience, J Neuroscience, PNAS, Cerebral Cortex, Cerebral Blood Flow and Metabolism, Journal of Neurophysiology, Experimental Brain Research, and Vision Research. He is a member of the Society for Neuroscience, European Neuroscience Association, American Association for the Advancement of Science, Association for Research in Vision and Ophthalmology, New York Academy of Sciences, Society for Industrial and Applied Mathematics, American Mathematical Society, International Neuropsychological Society, and Mathematical Association of America.

Nikos K. Logothetis is member of the German Academy of Natural Scientists Leopoldina, of the Rodin Remediation Academy, Honorary Member of the American Academy of Arts and Sciences, and a foreign associate of the National Academy of Sciences of the United States. He is recipient of the DeBakey Award for Excellence in Science, the Golden Brain Award of the Minerva Foundation, the 2003 Louis-Jeantet Prize of Medicine, the 2004 Zülch-Price for Neuroscience, the 2007 IPSEN Prize for Neuronal Plasticity, and the 2008 Alden Spencer Award of Columbia University, New York.

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Artikel (333):

Einevoll GT, Kayser C, Logothetis NK und Panzeri S (November-2013) Modelling and analysis of local field potentials for studying the function of cortical circuits Nature Reviews Neuroscience 14(11) 770-785.
Watanabe M, Bartels A, Macke JH, Murayama Y und Logothetis NK (November-2013) Temporal Jitter of the BOLD Signal Reveals a Reliable Initial Dip and Improved Spatial Resolution Current Biology 23(21) 2146–2150.
Shao Y, Keliris GA, Papanikolaou A, Fischer MD, Zobor D, Jägle H, Logothetis NK und Smirnakis SM (November-2013) Visual cortex organisation in a macaque monkey with macular degeneration European Journal of Neuroscience 38(10) 3456–3464.
Buzsáki G, Logothetis NK und Singer W (Oktober-2013) Scaling brain size, keeping timing: evolutionary preservation of brain rhythms Neuron 80(3) 751–764.
Panagiotaropoulos TI, Kapoor V und Logothetis NK (September-2013) Desynchronization and rebound of beta oscillations during conscious and unconscious local neuronal processing in the macaque lateral prefrontal cortex Frontiers in Psychology 4(603) 1-10.
Gambino G, Engelmann J, Tei L, Botta M, Logothetis NK und Mamedov I (September-2013) Multimodal contrast agents for in vivo neuroanatomical analysis of monosynaptic connections Biomaterials 34(29) 7135–7142.
Placidi MP, Botta M, Kálmán FK, Hagberg GE, Baranyai Z, Krenzer A, Rogerson AK, Tóth I, Logothetis NK und Angelovski G (August-2013) Aryl-Phosphonate Lanthanide Complexes and Their Fluorinated Derivatives: Investigation of Their Unusual Relaxometric Behavior and Potential Application as Dual Frequency 1H/19F MRI Probes Chemistry - A European Journal 19(35) 11644–11660.
Kapoor V, Krampe E, Klug A, Logothetis NK und Panagiotaropoulos TI (Mai-2013) Development of Tube Tetrodes and a Multi-Tetrode Drive for deep structure electrophysiological recordings in the macaque brain Journal of Neuroscience Methods 216(1) 43–48.
Ng BSW, Logothetis NK und Kayser C (Februar-2013) EEG phase patterns reflect the selectivity of neural firing Cerebral Cortex 23(2) 389-398.
Vibhute SM, Engelmann J, Verbić T, Maier ME, Logothetis NK und Angelovski G (Februar-2013) Synthesis and characterization of pH-sensitive, biotinylated MRI contrast agents and their conjugates with avidin Organic & Biomolecular Chemistry 11(8) 1294-1305.
Panagiotaropoulos TI, Kapoor V, Logothetis NK und Deco G (Januar-2013) A Common Neurodynamical Mechanism Could Mediate Externally Induced and Intrinsically Generated Transitions in Visual Awareness PLoS ONE 8(1) 1-10.
Turesson HK, Logothetis NK und Hoffman KL (November-2012) Category-selective phase coding in the superior temporal sulcus Proceedings of the National Academy of Sciences of the United States of America 109(47) 19438-19443.
Goense J, Merkle H und Logothetis NK (November-2012) High-Resolution fMRI Reveals Laminar Differences in Neurovascular Coupling between Positive and Negative BOLD Responses Neuron 76(3) 629–639.
Logothetis NK, Eschenko O, Murayama Y, Augath M, Steudel T, Evrard HC, Besserve M und Oeltermann A (November-2012) Hippocampal-cortical interaction during periods of subcortical silence Nature 491(7425) 547–553.
Ince RAA, Mazzoni A, Bartels A, Logothetis NK und Panzeri S (September-2012) A novel test to determine the significance of neural selectivity to single and multiple potentially correlated stimulus features Journal of Neuroscience Methods 210(1) 49–65.
Keliris A, Mamedov I, Hagberg GE, Logothetis NK, Scheffler K und Engelmann J (September-2012) A smart 19F and 1H MRI probe with self-immolative linker as a versatile tool for detection of enzymes Contrast Media & Molecular Imaging 7(5) 478–483.
Dhingra Verma K, Mishra A, Engelmann J, Beyerlein M, Maier ME und Logothetis NK (September-2012) Magnetic-Field-Dependent 1H Relaxivity Behavior of Biotin/Avidin-Based Magnetic Resonance Imaging Probes ChemPlusChem 77(9) 758–769.
Magri C, Mazzoni A, Logothetis NK und Panzeri S (September-2012) Optimal Band Separation of Extracellular Field Potentials Journal of Neuroscience Methods 210(1) 66–78.
Fischer MD, Zobor D, Keliris GA, Shao Y, Seeliger MW, Haverkamp S, Jägle H, Logothetis NK und Smirnakis SM (August-2012) Detailed functional and structural characterization of a macular lesion in a rhesus macaque Documenta Ophthalmologica 125(3) 179-194.
Logothetis NK (August-2012) Intracortical recordings and fMRI: An attempt to study operational modules and networks simultaneously NeuroImage 62(2) 962–969.
Biessmann F, Murayama Y, Logothetis NK, Müller KR und Meinecke FC (Juli-2012) Improved decoding of neural activity from fMRI signals using non-separable spatiotemporal deconvolutions NeuroImage 61(4) 1031–1042.
Valverde Salzmann MF, Bartels A, Logothetis NK und Schüz A (Juni-2012) Color Blobs in Cortical Areas V1 and V2 of the New World Monkey Callithrix jacchus, Revealed by Non-Differential Optical Imaging Journal of Neuroscience 32(23) 7881-7894.
Panagiotaropoulos TI, Deco G, Kapoor V und Logothetis NK (Juni-2012) Neuronal Discharges and Gamma Oscillations Explicitly Reflect Visual Consciousness in the Lateral Prefrontal Cortex Neuron 74(5) 924–935.
von Pföstl V, Li J, Zaldivar D, Goense J, Zhang X, Serr N, Logothetis NK und Rauch A (Mai-2012) Effects of lactate on the early visual cortex of non-human primates, investigated by pharmaco-MRI and neurochemical analysis NeuroImage 61(1) 98–105.
Evrard HC, Forro T und Logothetis NK (Mai-2012) Von economo neurons in the anterior insula of the macaque monkey Neuron 74(3) 482–489.
Mishra A, Joshi R, Engelmann J und Logothetis NK (April-2012) Synthesis and in Vitro Evaluation of a Biotinylated Dextran-Derived Probe for Molecular Imaging ACS Chemical Neuroscience 3(4) 268–273.
Fischer E, Logothetis NK, Bülthoff HH und Bartels A (April-2012) Visual Motion Responses in the Posterior Cingulate Sulcus: A Comparison to V5/MT and MST Cerebral Cortex 22(4) 865-876.
Fischer E, Bülthoff HH, Logothetis NK und Bartels A (März-2012) Human Areas V3A and V6 Compensate for Self-Induced Planar Visual Motion Neuron 73(6) 1228-1240.
Li J, von Pföstl V, Zaldivar D, Zhang X, Logothetis NK und Rauch A (März-2012) Measuring multiple neurochemicals and related metabolites in blood and brain of the rhesus monkey by using dual microdialysis sampling and capillary hydrophilic interaction chromatography-mass spectrometry Analytical and Bioanalytical Chemistry 402(8) 2545-2554.
Liebe S, Hoerzer GM, Logothetis NK und Rainer G (März-2012) Theta coupling between V4 and prefrontal cortex predicts visual short-term memory performance Nature Neuroscience 15(3) 456-462.
Mamedov I, Engelmann J, Eschenko O, Beyerlein M und Logothetis NK (Februar-2012) Dual-functional probes towards in vivo studies of brain connectivity and plasticity Chemical Communications 48(22) 2755-2757.
Brasselet R, Panzeri S, Logothetis NK und Kayser C (Februar-2012) Neurons with stereotyped and rapid responses provide a reference frame for relative temporal coding in primate auditory cortex Journal of Neuroscience 32(9) 2998-3008.
Eschenko O, Evrard HC, Neves RM, Beyerlein M, Murayama Y und Logothetis NK (Februar-2012) Tracing of noradrenergic projections using manganese-enhanced MRI NeuroImage 59(4) 3252–3265.
Stoewer S, Goense J, Keliris GA, Bartels A, Logothetis NK, Duncan J und Sigala N (Januar-2012) An Analysis Approach for High-Field fMRI Data from Awake Non-Human Primates PLoS One 7(1) 1-13.
Borchers S, Himmelbach M, Logothetis NK und Karnath HO (Januar-2012) Direct electrical stimulation of human cortex: the gold standard for mapping brain functions? Nature Reviews Neuroscience 13(1) 63-70.
Goense J, Whittingstall K und Logothetis NK (Januar-2012) Neural and BOLD responses across the brain Wiley Interdisciplinary Reviews: Cognitive Science 3(1) 75–86.
Magri C, Schridde U, Murayama Y, Panzeri S und Logothetis NK (Januar-2012) The Amplitude and Timing of the BOLD Signal Reflects the Relationship between Local Field Potential Power at Different Frequencies Journal of Neuroscience 32(4) 1395-1407.
Murayama Y, Augath M und Logothetis NK (Dezember-2011) Activation of SC during electrical stimulation of LGN: retinal antidromic stimulation or corticocollicular activation? Magnetic Resonance Imaging 29(10) 1351-1357.
Magri C, Logothetis NK und Panzeri S (Dezember-2011) Investigating static nonlinearities in neurovascular coupling Magnetic Resonance Imaging 29(10) 1358-1364.
Stoewer S, Goense J, Keliris GA, Bartels A, Logothetis NK, Duncan J und Sigala N (Dezember-2011) Realignment strategies for awake-monkey fMRI data Magnetic Resonance Imaging 29(10) 1390-1400.
Bartlett AM, Ovaysikia S, Logothetis NK und Hoffman KL (Dezember-2011) Saccades during Object Viewing Modulate Oscillatory Phase in the Superior Temporal Sulcus Journal of Neuroscience 31(5) 18423-18432.
Watanabe M, Cheng K, Murayama Y, Ueno K, Asamizuya T, Tanaka K und Logothetis NK (November-2011) Attention But Not Awareness Modulates the BOLD Signal in the Human V1 During Binocular Suppression Science 334(6057) 829-831.
Aggelopoulos NC, Liebe S, Logothetis NK und Rainer G (November-2011) Cholinergic control of visual categorization in macaques Frontiers in Behavioral Neuroscience 5(73) 1-10.
Theodoni P, Panagiotaropoulos TI, Kapoor V, Logothetis NK und Deco G (November-2011) Cortical microcircuit dynamics mediating binocular rivalry: the role of adaptation in inhibition Frontiers in Human Neuroscience 5(145) 1-19.
Mishra A, Schüz A, Engelmann J, Beyerlein M, Logothetis NK und Canals S (Oktober-2011) Biocytin-derived MRI contrast agent for longitudinal brain connectivity studies ACS Chemical Neuroscience 2(10) 578–587.
Dahl CD, Logothetis NK, Bülthoff HH und Wallraven C (Oktober-2011) Second-Order Relational Manipulations Affect Both Humans and Monkeys PLoS One 6(10) 1-7.
Placidi MP, Engelmann J, Natrajan LS, Logothetis NK und Angelovski G (September-2011) An aryl-phosphonate appended macrocyclic platform for lanthanide based bimodal imaging agents Chemical Communications 47(41) 11534-11536.
Valverde Salzmann MF, Wallace DJ, Logothetis NK und Schüz A (September-2011) Multimodal vessel mapping for precise large area alignment of functional optical imaging data to neuroanatomical preparations in marmosets Journal of Neuroscience Methods 201(1) 159-172.
Bartels A, Vazquez-Zuniga Y, Schindler A und Logothetis NK (August-2011) Rivalry between afterimages and real images: the influence of the percept and the eye Journal of Vision 11(9:7) 1-13.
Perrodin C, Kayser C, Logothetis NK und Petkov C (August-2011) Voice Cells in the Primate Temporal Lobe Current Biology 21(16) 1408-1415.
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Last updated: Montag, 22.05.2017