Contact

Dr. phil. Gisela Hagberg

Adresse: Spemannstr. 41
72076 Tübingen
Raum Nummer: 3.B.09
Tel.: 07071 601 1648
Fax: 07071 601 652
E-Mail: gisela.hagberg

 

Bild von Hagberg, Gisela, Dr. phil.

Gisela Hagberg

Position: Gastwissenschaftler  Abteilung: Scheffler

Anwendungen der Hoch-Feld MRT in klinisch-wissenschaftlichen Studien zur Mikrostruktur des menschlichen Gehirns

Ultra-hohe Magnetfelder erlauben sehr detaillierte, nicht-invasive, strukturelle und funktionelle Untersuchungen des menschlichen Gehirns.

 

MR-basierte Signale entstehen wiederum auf einer noch mehr detaillierteren Ebene, auf Grund kleiner Bewegungen der Wasser Moleküle durch die anatomische Vielfalt des Gehirns.  Die Gewebsstruktur und ihre Zusammensetzung erzeugen lokale magnetische Effekte auf das Wasser, die mit der Gehirn-Funktion oder Pathologische Prozesse sich stets in Wandel befinden.

Der  Schwerpunkt meiner Forschung liegt im Bereich der Untersuchung solche pathophysiologische Prozesse mit MR Methoden. Hierbei möchte ich herausfinden wie im MR Bild Kontraste erzeugt und quantifiziert werden können die der mikrostrukturellen  Einflüsse entsprechen.  Das Ziel ist es Methoden bei Ultrahohe Magnetfeldern zu erarbeiten, die quantitative anatomische und  MR Studien erlauben und neue medizinische Nutzfelder ermöglichen.

A core of quantitative MRI tools

for clinical and neuroscientific in vivo research at 9.4T has been established. Besides mapping of the transmit field, necessary to correct for the strong inhomogeneity, they consist of MP2RAGE-based mapping of the longitudinal relaxation (T1; R1) with isotropic voxel-sizes of 800µm down to 300µm; a multi echo 3D GRE sequence; with voxel-sizes of 375x375x800µm down to an isotropic voxel size of 400µm mainly for mapping the effective transverse relaxation (T2*; R2*), but that can also be used for quantitative susceptibility mapping (QSM); and a high-resolution acquisition weighted, single-echo 3D GRE sequence; with voxel-sizes down to 113x118x600µm used for QSM.

The whole protocol has a total duration of 45min and is therefore suited for clinical examinations of patients using a multi-modal imaging approach but without too harsh constraints on patient compliance. For validation purposes, this core of sequences has been complemented with single slice inversion-recovery mapping of T1 using EPI, and CPMG based mapping of T2, with an echo train consisting of 32 echoes and a minimum inter-echo time of 9ms, without exceeding SAR limits.

These protocols have been used to elucidate amongst other age-depndent variation in healthy subjects, the anatomical detail of the superior colliculus, beta-amyloid plaques in Alzheimer's and in post-mortem tissue.

The severe inhomogeneity of the transmit field poses a limit for quantitative studies at 9.4T. We found that this factor not only affects the MR signal excitation, but also impacts inversion efficiency, despite the use of adiabatic pulses. Such pulses are generally assumed to be immune to variations in B1, but through Bloch simulations and experiments we could confirm studies from the early ’90 demonstrating the vulnerability of that assumption (Hagberg et al., 2017). These findings further led us to propose an efficient correction for T1 (R1) mapping at 9.4T that tackles this issue and yields a high in vivo test-retest variability (< 1%) and low coefficient-of-variation (CoV<3% across 25 subjects at the level of extended regions-of-interest). Consistent with previous studies, we found that the primary sensory and motor areas had the greatest quantitative R1 values, in line with their greater myelin content with respect to other brain areas, and observed that the quantitative MRI parameters measured at 9.4T have a greater dynamic range than at 3T (Fig. 1). Nevertheless we could observe that the voxel wise CoV reached levels beyond 15% in grey matter regions, being several fold higher than in white matter voxels. This is interesting in view of the difficulty to detect myelin-related signals outside the white matter at 3T (Groeschel et al., 2016). Upon closer scrutiny we found that this effect derives from age-related variation in R1. The observed dynamics of MR-parameters across the human life-span could be explained in a model that takes into account decreasing grey matter volume fractions, increased iron levels and increased myelination of the cortical fibers with age (Fig. 2 and Hagberg et al., 2017b).

With further advancing age, several changes of the brain microstructure occur that may impact quantitative MRI measures. With age, the likelihood of presenting β-amyloid deposits increases, with prevalence peaking at age 70, even in a cognitively healthy population (Jack et al., 2017). In patient populations showing mild cognitive impairment, early identification of the presence of such deposits is essential since patients without them have a different clinical course towards non-Alzheimer dementia. Recently we found that QSM of post mortem samples can detect single β-amyloid plaques in Alzheimer’s at 14.1T, but only when voxel-sizes (37-50µm) on the order of the size of single plaques were employed (Fig. 3 and Tuzzi et al., 2016; 2017). This finding poses important questions regarding the best imaging protocols to use for in vivo MRI and the resolution necessary to answer clinical questions at UHF, since pathology–related effects of β-amyloid can be detected at high field but with coarser sampling (van Rooden et al., 2016).

A particularly challenging area for MRI research are the function and the anatomy of the deep brain nuclei located in the midbrain, characterized by a limited available signal-to-noise-ratio and a strong variation in background magnetic susceptibility. The superior colliculus (SC) is one of these brain nuclei and is a layered structure which serves as a gateway for several sensory modalities. Up-to-date, the layering pattern could only be identified in histology, or in vivo by functional challenge. We recently showed that layer specific fMRI activations of the superior colliculus (SC) can be detected at 9.4T (Loureiro 2017a). More recently (Loureiro 2016; 2017b) we found that the combined use of several quantitative MRI parameters provides a mean to study layer specific anatomy of the SC in vivo with features that are sensitive to the local microstructure that are reproducible across subjects. Moreover we observed that the combined use of several MRI parameters enabled identification of several anatomical structures within the midbrain areas (Fig. 4). Along with these measurements we employed MRI of post mortem samples at 14.1T and polarized light microscopy imaging to validate our observations regarding detectability of white matter fascicles in the brain stem. We are currently pursuing research activities in this direction with the aim to pin-point the source behind the obtained quantitative MRI measures and have extended our focus to include signal variations within and beyond the cortical rim in the occipital cortex (Fig. 5).

 

Wissenschaftlicher Werdegang
Seit 06/2012    Projektleiterin, Hochfeld Magnetresonanz, Max-Planck-Institut für Biologische Kybernetik  und Abt. Biomedizinische Magnetresonanz, Universitätsklinikum Tübingen, Deutschland
09/10-05/12    Wissenschaftliche Mitarbeiterin, Max-Planck-Institut für Biologische Kybernetik, Abt. Physiologie kognitiver Prozesse, Tübingen, Deutschland
06/06-08/10    Gruppenleiterin MR Physik, Fondazione Santa Lucia IRCCS, Rom, Italien;
12/2007    Medizin Physik Expertin (MPE), Università Sapienza, Rom, Italien
04/99-06/06    Wissensch. Mitarbeiterin, Fondazione Santa Lucia IRCCS, Rom, Italien
03/99-03/03    Wissensch. Mitarbeiterin, 10% PET centre, Uppsala Universität, Schweden
06/96-02/99        Wissensch. Mitarbeiterin (100%) Positron EmissionTomography (PET) Centre, Uppsala Universität, Schweden
12/94-12/95    Post-Doktorandin, Dep. Pharmacokinetics, Pharmacia&Upjohn, Milano, Italien
07/93-06/94    Post-Doktorandin, Abt. Biophysikalische Chemie, Universität Basel, Schweiz
06/1993    Doktor der Philosophie, verliehen durch die Universität Basel, Schweiz
Thema: Metabolism of the Human Brain Investigated by 1H-MRS
06/90-06/93    Doktorandin, Abt. Biophysikalische Chemie, Universität Basel, Schweiz
10/90        Diplom-Ingenieur Physik, Lunds Tekniska Högskola (LTH) Schweden
01/90        Diplom-Ingenieur Physik Ecole Polytechnique Fédérale de Lausanne, Schweiz
04/88-01/90    Hauptstudium der Physik an der Ecole Polytechnique Fédérale de Lausanne, Schweiz, im Rahmen eines europäischen Doppeldiplomprogramms mit den Schwerpunkten Physik und allgemeine Ingenieurwissenschaften
09/85-03/88    Grundstudium der Physik an Lunds Tekniska Högskola (LTH) Schweden

Publikationen

Anzahl insgesamt: 62 peer-reviewed; 5 Buchkapiteln, 3 Patente, h-index 26/31; i10: 52 (siehe: http://www.researcherid.com/rid/A-2134-2010 sowie Google Scholar)

Mitgliedschaft
•    Society for Magnetic Resonance in Medicine, ISMRM
•    Italienische Gesellschaft für Medizinische Physik, AIFM
•    Italienischer Verband für Strahlungs Forschung, FIRR
•    European Society for Molecular Imaging

Eingeworbene Drittmittel
05/13 – 04/15 Functional neuroimaging of the human brainstem at 9.4T Werner Reichardt Centre for Integrative Neurosciences    
04/06 - 03/08 Cognitive control during aging: physiology of decline and preclinical evaluation Italian Ministry of Health
04/01 – 03/03 Prognosis for functional motor recovery post-stroke: a study of anatomically correlated neurophysiology Italian Ministry of Health
04/01 – 03/03 Neuropsychological, genetic and neurobiological basis of cerebellar injury Italian Ministry of Health     

Gremienarbeit
Gremiums-Mitglied der Italienischer Verband für Strahlungs Forschung, FIRR, 2008-2012
Scientific Committe:
•    Tagungen der AIFM: 2011 und 2013
•    EFOMP/ESMRMB/AIFM Kurs, Udine 22-15.10.2010
Advances in High Field Magnetic Resonance Imaging
•    Workshop, FIRR, Rom 14.5.2009
Radiation: Biology, Clinic, Environment, und Protection

Lehre
Lehrveranstaltungen: Universität Tübingen (Anwendungen der MRI in klinische und neurowissenschaftliche Forschung; MRI Kontrast im Rahmen der Medizintechnik); Universität Tor Vergata, Rom (Angewandte Physik); Fondazione Santa Lucia (Brain Imaging)
Betreuung von Studenten und Doktoranden: Phd (3); MSc (3); Spezialisierung der Medizinphysik (1)
Eingeladen Vorträge: Karolinska Institutet - Stockholm, CNR - Genova, International School on Magnetic Resonance and Brain Function – Erice, Strasbourg, France, Radboud University, Nijmegen, The Netherlands; Workshops und Kongresse: AIFM und ISMRM

Präferenzen: 
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Artikel (16):

Pavlova MA, Erb M, Hagberg GE, Loureiro J, Sokolov AN und Scheffler K (November-2017) "Wrong Way Up": Temporal and Spatial Dynamics of the Networks for Body Motion Processing at 9.4 T Cerebral Cortex 27(11) 5318–5330.
Loureiro JR, Hagberg GE, Ethofer T, Erb M, Bause J, Ehses P, Scheffler K und Himmelbach M (Januar-2017) Depth-dependence of visual signals in the human superior colliculus at 9.4 T Human Brain Mapping 38(1) 574–587.
Hagberg GE, Bause J, Ethofer T, Ehses P, Dresler T, Herbert C, Pohmann R, Shajan G, Fallgatter A, Pavlova MA und Scheffler K (Januar-2017) Whole brain MP2RAGE-based mapping of the longitudinal relaxation time at 9.4T NeuroImage 144(Part A) 203–216.
Groeschel S, Hagberg GE, Schultz T, Balla DZ, Klose U, Hauser T-K, Nägele T, Bieri O, Prasloski T, MacKay AL, Krägeloh-Mann I und Scheffler K (November-2016) Assessing White Matter Microstructure in Brain Regions with Different Myelin Architecture Using MRI PLoS ONE 11(11) 1-23.
Bisdas S, Chadzynski GL, Braun C, Schittenhelm J, Skardelly M, Hagberg GE, Ethofer T, Pohmann R, Shajan G, Engelmann J, Tabatabai G, Ziemann U, Ernemann U und Scheffler K (Oktober-2016) MR spectroscopy for in vivo assessment of the oncometabolite 2-hydroxyglutarate and its effects on cellular metabolism in human brain gliomas at 9.4T Journal of Magnetic Resonance Imaging 44(4) 823–833.
Di Pietro G, Capuani S, Manenti G, Vinicola V, Fusco A, Baldi J, Scimeca M, Hagberg G, Bozzali M, Simonetti G und Tarantino U (März-2016) Bone Marrow Lipid Profiles from Peripheral Skeleton as Potential Biomarkers for Osteoporosis: A 1H-MR Spectroscopy Study Academic Radiology 23(3) 273–283.
Balla DZ, Sanchez-Panchuelo RM, Wharton SJ, Hagberg GE, Scheffler K, Francis ST und Bowtell R (Oktober-2014) Functional quantitative susceptibility mapping (fQSM) NeuroImage 100 112–124.
Kadjane P, Platas-Iglesias C, Boehm-Sturm P, Truffault V, Hagberg GE, Hoehn M, Logothetis NK und Angelovski G (Juni-2014) Dual-Frequency Calcium-Responsive MRI Agents Chemistry: A European Journal 20(24) 7351–7362.
Angelovski G, Gottschalk S, Milošević M, Engelmann J, Hagberg GE, Kadjane P, Andjus P und Logothetis NK (Mai-2014) Investigation of a Calcium-Responsive Contrast Agent in Cellular Model Systems: Feasibility for Use as a Smart Molecular Probe in Functional MRI ACS Chemical Neuroscience 5(5) 360–369.
Hagberg G, Mamedov I, Power A, Beyerlein M, Merkle H, Kiselev VG, Dhingra K, Kubìček V, Angelovski G und Logothetis NK (Januar-2014) Diffusion properties of conventional and calcium-sensitive MRI contrast agents in the rat cerebral cortex Contrast Media & Molecular Imaging 9(1) 71–82.
Hagberg GE und Scheffler K (November-2013) Effect of r1 and r2 relaxivity of gadolinium-based contrast agents on the T1-weighted MR signal at increasing magnetic field strengths Contrast Media & Molecular Imaging 8(6) 456–465.
Placidi MP, Botta M, Kálmán FK, Hagberg GE, Baranyai Z, Krenzer A, Rogerson AK, Tóth I, Logothetis NK und Angelovski G (August-2013) Aryl-Phosphonate Lanthanide Complexes and Their Fluorinated Derivatives: Investigation of Their Unusual Relaxometric Behavior and Potential Application as Dual Frequency 1H/19F MRI Probes Chemistry - A European Journal 19(35) 11644–11660.
Pohmann R, Shajan G, Hoffmann J, Budde J, Hagberg G, Bieri O, Bisdas S, Ernemann U, Weigel M, Ehses P, Hennig J, Chadzynski G und Scheffler K (April-2013) Imaging and Spectroscopy at 9.4 Tesla: First Results on Patients and Volunteers MAGNETOM Flash 2013(2) 58-67.
Keliris A, Mamedov I, Hagberg GE, Logothetis NK, Scheffler K und Engelmann J (September-2012) A smart 19F and 1H MRI probe with self-immolative linker as a versatile tool for detection of enzymes Contrast Media & Molecular Imaging 7(5) 478–483.
Hagberg GE, Bianciardi M, Brainovich V, Cassara AN und Maraviglia B (Februar-2012) Phase stability in fMRI time series: Effect of noise regression, off-resonance correction and spatial filtering techniques NeuroImage 59(4) 3748–3761.
Hagberg G, Gefvert O, Bergström M, Wieselgren I-M, Lindström L, Wiesel F-A und Långström B (Juni-1998) N-[11C]Methylspiperone PET, in contrast to [11C]raclopride, fails to detect D2 receptor occupancy by an atypical neuroleptic Psychiatry Research: Neuroimaging 82(3) 147–160.

Beiträge zu Tagungsbänden (1):

Bianciardi M, Sirabella P, Hagberg G, Giuliani A, Zbilut JP und Colosimo A (September-2004) Analyzing Spatial Distributions of FMRI "Bold" Signals by RQA Variables, International Meeting Complexity in the living: a problem-oriented approach, Istituto Superiore di Sanità, Roma, Italy, 238-243, Series: Rapporti ISTISAN ; 05/20.

Beiträge zu Büchern (2):

Garreffa G, Hagberg G und Indovina L: Physics of Hybrid Imaging, 3-12. In: PET-CT and PET-MRI in Neurology, (Ed) A. Ciarmiello, Springer, Cham, Switzerland, (2016).
Hagberg GE und Tuzzi E: Phase Variations in fMRI Time Series Analysis: Friend or Foe?, 81-113. In: Advanced Brain Neuroimaging Topics in Health and Disease: Methods and Applications, (Ed) T.D. Papageorgiou, InTech, Rijeka, Croatia, (Mai-2014).

Poster (26):

Pavlova M, Erb M, Hagberg G, Loureiro J, Sokolov AN und Scheffler K (November-15-2017): Spatial and temporal dynamics of the networks for body motion processing, 47th Annual Meeting of the Society for Neuroscience (Neuroscience 2017), Washington, DC, USA.
Cassara A, Neufeld E, Hagberg G, Guidon M, Scheffler K und Kuster N (April-27-2017): Peripheral Nerve Stimulation in MRI: Insights from a three level analysis and coupled EM-electrophysiological simulations in neuro-functionalized human models, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Hagberg G, Bause J, Ethofer T, Ehses P, Dresler T, Herbert C, Pohmann R, Shajan G, Fallgatter A, Pavlova M und Scheffler K (April-26-2017): Factors influencing the detection of age-dependent variations of cortical myelin by MP2RAGE at 9.4T, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Loureiro J, Hagberg G, Tuzzi E, Pohmann R, Schickardt Z, Himmelbach M, Ethofer T, Valverde M, Grodd W und Scheffler K (April-24-2017): Biological underpinnings of different MR contrasts in the human midbrain using quantitative structural MR imaging at 9.4T: Validation with 14T ex-vivo measurements and PLI, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.
Hagberg G, Keliris A, Srinivas M, Schulz H, Engelmann J, Schmehl J, Bantleon R, Mannheim J, Fuchs K, Pichler B, van der Linden A und Scheffler K (April-6-2017): 19F MRI-based detection of human mesenchymal stem cells (hMSC) labelled with fluorinated-PLGA nanoparticles, 12th Annual Meeting of the European Society for Molecular Imaging (EMIM 2017), Köln, Germany.
Pavlova M, Erb M, Hagberg G und Scheffler K (November-13-2016): Body motion presented upright and upside-down: Human ultra high field 9.4T fMRI, 46th Annual Meeting of the Society for Neuroscience (Neuroscience 2016), San Diego, CA, USA.
Pavlova MA, Erb M, Hagberg G, Sokolov A und Scheffler K (September-1-2016): Biological motion presented with upright and inverted display orientation: Human ultra high field 9.4 T fMRI, 39th European Conference on Visual Perception (ECVP 2016), Barcelona, Spain, Perception, 45(ECVP Abstract Supplement) 294-295.
Pavlova M, Erb M, Hagberg G, Loureiro J und Scheffler K (Juni-29-2016): Body motion presented upside-down: Human ultra-high field 9.4T fMRI, 22nd Annual Meeting of the Organization for Human Brain Mapping (OHBM 2016), Geneva, Switzerland.
Martin P, Hagberg G, Loureiro J, Bause J, Erb M, Lerche H, Scheffler K und Focke N (Januar-15-2016): Strukturelle Hochfeld-MRT-Bildgebung bei Epilepsie, Forschungskolloquium 2016 der Medizinischen Fakultät, Tübingen, Germany.
Loureiro JRA, Hagberg G, Ethofer T, Erb M, Scheffler K und Himmelbach M (Oktober-19-2015): Depth-dependence of visual signals in the human superior colliculus: Comparison between 3T and 9.4T, 45th Annual Meeting of the Society for Neuroscience (Neuroscience 2015), Chicago, IL, USA.
Chadzynski G, Hagberg GE, Bause J, Shajan G, Bisdas S, Pohmann R, Engelmann J und Scheffler K (März-20-2015): Assessment of human brain tumors with proton magnetic resonance spectroscopic imaging at 9.4 Tesla, 10th Annual Meeting of the European Society for Molecular Imaging (EMIM 2015), Tübingen, Germany.
Hagberg GE, Keliris A, Srinivas M, Schulz H, Engelmann J, Schmehl J, Bantleon R und Scheffler K (März-19-2015): Characterization and MRI detection of 19F-PLGA labelled human mesenchymal stem cells, 10th Annual Meeting of the European Society for Molecular Imaging (EMIM 2015), Tübingen, Germany.
Chadzynski G, Bause J, Hagberg GE, Shajan G, Pohmann R, Engelmann J und Scheffler K (März-19-2015): Free induction decay proton magnetic resonance spectroscopic imaging in the healthy human brain at 9.4 Tesla: initial results, 10th Annual Meeting of the European Society for Molecular Imaging (EMIM 2015), Tübingen, Germany.
Keliris A, Engelmann J, Hagberg GE und Scheffler K (März-19-2015): Self-assembling peptide based system for detection of enzymatic activity by means of MRI, 10th Annual Meeting of the European Society for Molecular Imaging (EMIM 2015), Tübingen, Germany.
Sánchez-Castañeda C, Hagberg G, Squitieri F und Sabatini U (September-2014): Progressive Iron Accumulation In Huntington Disease Basal Ganglia: A Longitudinal Study, European Huntington’s Disease Network 8th Plenary Meeting, Barcelona, Spain, Journal of Neurology, Neurosurgery & Psychiatry, 85(Suppelment 1) A37-A38.
Hagberg GE, Martirosian P, Bause J, Shajan G, Klose U und Scheffler K (April-25-2013): Time-Of-Flight Angiography in Humans at 9.4T, 21st Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT, USA.
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Hagberg GE, Keliris A, Mamedov I, Placidi M, Merkle H, Logothetis NK und Scheffler K (April-23-2013): 19F-Lanthanide Complexes: T1 - and T2 - Dependent Signal Gain Using Gradient Echoes, 21st Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT, USA.
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Chadzynski G, Bisdas S, Hagberg G, Pohmann R, Shajan G, Kolb R, Klose U und Scheffler K (April-23-2013): First Proton CSI of a Human Brain Tumor at 9.4T, 21st Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2013), Salt Lake City, UT, USA.
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Hagberg GE, Mamedov I, Power A, Beyerlein M, Merckle H, Dhingra K, Kubicek V und Logothetis NK (November-2012): Diffusion of conventional and calcium sensitive MRI contrast agents in the rat cerebral cortex, Fifth Annual World Molecular Imaging Congress (WMIC 2012), Dublin, Ireland, Molecular Imaging and Biology, 14(Supplement 2) S1544.
Keliris A, Mamedov I, Hagberg GE, Logothetis NK, Scheffler K und Engelmann J (November-2012): Dual 1H/19F MR imaging approach for detection of enzyme activity, Fifth Annual World Molecular Imaging Congress (WMIC 2012), Dublin, Ireland, Molecular Imaging and Biology, 14(Supplement 2) S1235.
Hagberg GE, Mamedov I, Placidi M, Keliris A, Merkle H, Logothetis NK und Scheffler K (Oktober-29-2012): 19F-Lanthanide complexes: T1- and T2-dependent signal gain using gradient echoes, ENCITE Symposium "Red hot MRI: In vivo 19F imaging", Nijmegen, The Netherlands.
Cassara AM, Körber R, Burghoff M, Hagberg G, Maraviglia B und Hartwig S (August-2012): Phase Imaging at Ultra-Low Field MRI, 18th International Conference on Biomagnetism (BIOMAG 2012), Paris, France.
Hagberg GE, Mamedov I, Power A, Beyerlein M, Merkle H, Angelovski G und Logothetis NK (Mai-9-2012): Diffusion in the extra-cellular space of the rat cerebral cortex probed by MRI and direct infusion of contrast agents, 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia.
Mamedov I, Engelmann J, Hagberg G, Eschenko O und Logothetis NK (Mai-8-2012): Development of multimodal imaging probes for neuroanatomical connectivity studies in vivo by means of MRI, 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012), Melbourne, Australia.
Hagberg GE, Balla D, Wiesner HM und Logothetis NK (Mai-9-2011): Small-Scale Phase & Magnitude Fluctuations in fMRI Time Series, 19th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2011), Montréal, Canada.
Bianciardi M, Cerasa A und Hagberg G (Juni-2003): How experimental design and first-level filtering influence efficiency in second-level analysis of event-related fMRI data, 9th International Conference on Functional Mapping of the Human Brain (HBM 2003), New York, NY, USA, NeuroImage, 19(2 Supplement) e1503-e1504.

Vorträge (20):

Bause J, Aghaeifar A, Hagberg G, Engel E-M, Avdievitch N, Scheffler K und Pohmann R (September-11-2017) Abstract Talk: 350 μm Isotropic Whole-Brain MP2RAGE without Averaging, ISMRM Workshop on Motion Correction in MRI & MRS (MoCor 2017), Cape Town, South Africa.
Tuzzi E, Hagberg G, Balla D, Loureiro J, Neumann M, Laske C, Pohmann R und Valverde M (April-27-2017) Abstract Talk: In-vivo and ex-vivo R2* and Quantitative Susceptibility Mapping in Alzheimer’s Disease at Ultra-High Magnetic Field compared to Histology, 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA 677-678.
Martin P, Hagberg G, Loureiro J, Bause J, Lerche H, Focke N und Scheffler K (Oktober-1-2016) Abstract Talk: Can 9.4 T MRI improve lesion visualization in epilepsy patients?, 33rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2016), Wien, Austria, Magnetic Resonance Materials in Physics, Biology and Medicine, 29(Supplement 1) S347-S348.
Loureiro J, Hagberg G, Tuzzi E, Himmelbach M, Ethofer T, Grodd W, Martin P, Valverde M, Pohmann R und Scheffler K (Oktober-1-2016) Abstract Talk: In-vivo ultra-high resolution structural imaging of the human superior colliculus at 9.4T: validation with ex vivo measurements at 9.4T and 14T, 33rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2016), Wien, Austria, Magnetic Resonance Materials in Physics, Biology and Medicine, 29(Supplement 1) S376-S377.
Tuzzi E, Hagberg G, Balla DZ, Loureiro J, Neumann M, Laske C, Pohmann R, Valverde M und Scheffler K (September-30-2016) Abstract Talk: Ex-vivo and in-vivo ultra-High-Field R2* and QSM microimaging in Alzheimer’s disease, 33rd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2016), Wien, Austria, Magnetic Resonance Materials in Physics, Biology and Medicine, 29(Supplement 1) S144-S145.
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Last updated: Montag, 22.05.2017